TRF2 - Mouse monoclonal [mta18 9f10 _ 1] to TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein Monoclonal
- Known as:
- TRF2 - Mouse mab [mta18 9f10 _ 1] TRF2; TTAGGG repeat-binding factor 2; Telomeric Desoxyribonucleic acid-binding protein Monoclonal
- Catalog number:
- 20-272-191031
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- TRF2 - Mouse monoclonal [mta18 9f10 _ 1] TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein Monoclonal
Related genes to: TRF2 - Mouse monoclonal [mta18 9f10 _ 1] to TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein Monoclonal
- Gene:
- TBPL1 NIH gene
- Name:
- TATA-box binding protein like 1
- Previous symbol:
- -
- Synonyms:
- TLP, STUD, TRF2, TLF
- Chromosome:
- 6q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2015-11-23
- Gene:
- TERF2 NIH gene
- Name:
- telomeric repeat binding factor 2
- Previous symbol:
- TRBF2
- Synonyms:
- TRF2
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-20
- Date modifiied:
- 2016-04-25
Related products to: TRF2 - Mouse monoclonal [mta18 9f10 _ 1] to TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein Monoclonal
Related articles to: TRF2 - Mouse monoclonal [mta18 9f10 _ 1] to TRF2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein Monoclonal
- Telomeres, repetitive DNA sequences at chromosome ends, are shielded against the DNA damage response (DDR) by the shelterin complex. To understand how shelterin protects telomere ends, we investigated the structural organization of telomeric chromatin in human cells using super-resolution microscopy. We found that telomeres form compact globular structures through a complex network of interactions between shelterin subunits and telomeric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telomeres and subtelomeric regions. Mutations that abrogate shelterin assembly or removal of individual subunits from telomeres cause up to a 10-fold increase in telomere volume. Decompacted telomeres accumulate DDR signals and become more accessible to telomere-associated proteins. Recompaction of telomeric chromatin using an orthogonal method displaces DDR signals from telomeres. These results reveal the chromatin remodeling activity of shelterin and demonstrate that shelterin-mediated compaction of telomeric chromatin provides robust protection of chromosome ends against the DDR machinery. - Source: PubMed
Bandaria Jigar NQin PeiwuBerk VeyselChu StevenYildiz Ahmet