Straight glass tube, 2ml for S20 pestle
- Known as:
- Straight glass tube, 2ml S20 pestle
- Catalog number:
- 099C S30
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Glcol
- Gene target:
- Straight glass tube 2ml for S20 pestle
Related genes to: Straight glass tube, 2ml for S20 pestle
- Gene:
- TSC2 NIH gene
- Name:
- TSC complex subunit 2
- Previous symbol:
- TSC4
- Synonyms:
- tuberin, LAM, PPP1R160
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: Straight glass tube, 2ml for S20 pestle
Related articles to: Straight glass tube, 2ml for S20 pestle
- The thyroid gland is susceptible to abnormal epithelial cell growth, often resulting in thyroid dysfunction. The serine-threonine protein kinase mechanistic target of rapamycin (mTOR) regulates cellular metabolism, proliferation, and growth through two different protein complexes, mTORC1 and mTORC2. The PI3K-Akt-mTORC1 pathway's overactivity is well associated with heightened aggressiveness in thyroid cancer, but recent studies indicate the involvement of mTORC2 as well. - Source: PubMed
Publication date: 2024/04/25
Ludke Rossetti CamilaAlves Bruna LourenconiMartins Pecanha Flavia LeticiaFranco AimeNosé VaniaCarneiro Everardo MagalhãesLew John IBernal-Mizrachi ErnestoWerneck de Castro Joao Pedro - Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous syndrome with variable phenotypes. Recent updates of TSC diagnostic criteria reaffirmed the defined genetic diagnostic criterion as the finding of a pathogenic DNA alteration in either TSC1 or TSC2 genes. It also slightly modified definite clinical diagnostic criteria. TSC-associated skin lesions in infancy are important clinical signs to select individuals with possible TSC for a closer clinical follow-up and genetic testing. - Source: PubMed
Publication date: 2024/04/23
Nunes Beatriz AzevedoRomano Ana Karolina Ferreira GonçalvesPasa Morgan Mariana AparecidaGonçalves Alice AndradeCardozo Laís Faria Masulkde Almeida Luiz Gustavo DufnerHaddad Luciana AmaralCrippa Ana Chrystina de SouzaAntoniuk Sergio AntonioAbagge Kerstin Taniguchi - Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease associated with the functional tumour suppressor genes TSC1 and TSC2 and causes structural destruction in the lungs, which could potentially increase the risk of lung cancer. However, this relationship remains unclear because of the rarity of the disease. - Source: PubMed
Publication date: 2024/04/23
Torasawa MasahiroShukuya TakehitoUemura KoheiHayashi TakuoUeno ToshihideKohsaka ShinjiMasui YoshihiroShirai YukinaOkura MakikoAsao TetsuhikoMitsuishi YoichiroShimada NaokoTakahashi FumiyukiTakamochi KazuyaSuzuki KenjiTakahashi KazuhisaSeyama Kuniaki - The plasticity and diversity of cell types with specialized functions likely defines the capacity of multicellular organisms to adapt to physiologic stressors. The kidney collecting ducts contribute to water, electrolyte, and pH homeostasis and are composed of mature intermingled epithelial cell types that are susceptible to transdifferentiate. The conversion of kidney collecting duct principal cells to intercalated cells is actively inhibited by Notch signaling to ensure urine concentrating capability. Here we identify Hes1, a target of Notch signaling, allows for maintenance of functionally distinct epithelial cell types within the same microenvironment by regulating mechanistic target of rapamycin complex 1 (mTORC1) activity. Hes1 directly represses the expression of ( ), an upstream component of mTOR pathway and suppresses mTORC1 activity in principal cells. Genetic inactivation of ( ) to increase mTORC1 activity in mature principal cells is sufficient to promote acquisition of intercalated cell properties, while inhibition of mTORC1 in adult kidney epithelia suppresses intercalated cell properties. Considering that mTORC1 integrates environmental cues, the linkage of functionally distinct epithelial cell types to mTORC1 activity levels likely allows for cell plasticity to be regulated by physiologic and metabolic signals and the ability to sense/transduce these signals. - Source: PubMed
Publication date: 2024/04/09
deRiso JenniferMukherjee MaliniJanga MadhusudhanaSimmons AliciaKareta MichaelTao JianningChandrasekar IndraSurendran Kameswaran - Granular cell apoptosis is a key factor leading to follicular atresia and decreased laying rate in aged laying hens. Endoplasmic reticulum stress (ERS) induced cell apoptosis is a new type of apoptosis pathway. Previous studies have shown that the ERS pathway is involved in the regulation of follicular development and atresia, and can be regulated by mTOR. Melatonin (MEL) can protect the normal development of follicles, but the precise mechanism by which MEL regulates follicular development is not yet clear. So, we investigated the potential relationship between MEL and ERS and mTOR signaling pathway in vivo through intraperitoneal injection of MEL in aged laying hens. The results show that the laying rate, ovarian follicle number, plasma MEL, E, LH, FSH concentrations, as well as the mRNA expression of mTOR signaling-associated genes TSC1, TSC2, mTOR, 4E-BP1, and S6K in old later-period chicken control (Old-CN) group was significantly decreased (P < 0.01). In contrast, the ERS-related of plasma and granular cell layer mRNA expression of Grp78, CHOP, and Caspase-3 was significantly increased (P < 0.01). While both of the effects were reversed by MEL. Then, aging granulosa cells were treated with MEL in vitro, followed by RNA seq analysis, and it was found that 259 and 322 genes were upregulated and downregulated. After performing GO enrichment analysis, it was found that DEGs significantly contribute to the biological processes including cell growth and apoptosis. Using pathway enrichment analysis, we found significant overrepresentation of cellular processes related to mTOR signaling and endoplasmic reticulum (ER) stress, involving genes such as GRB10, SGK1, PRKCA, RPS6KA2, RAF1, PIK3R3, FOXO1, DERL3, HMOX1, TLR7, VAMP7 and INSIG2. The obtained results of RT-PCR showed consistency with the RNA-Seq data. In summary, the underlined results revealed that MEL has significantly contributed to follicular development via activating the mTOR signaling pathway-related genes and alleviating ERS-related genes in laying hens. The current study provides a theoretical background for enhancing the egg-laying capability of hens and also providing a basis for elucidating the molecular mechanism of follicular selection. - Source: PubMed
Publication date: 2024/04/04
Hao Er-YingLiu Xue-LuChang Li-YunXue HanSu Bo-FeiChen Yi-FanWang De-HeShi LeiChen Hui