Signal Transduction: UBXN2B, 1-331aa, Human, His tag, E.coli
- Known as:
- Signal Transduction: UBXN2B, 1-331aa, Human, detection labelled, E.coli
- Catalog number:
- ATGP2155
- Product Quantity:
- 50ug
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- Signal Transduction: UBXN2B 1-331aa Human His tag .coli
Related genes to: Signal Transduction: UBXN2B, 1-331aa, Human, His tag, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- UBXN2B NIH gene
- Name:
- UBX domain protein 2B
- Previous symbol:
- -
- Synonyms:
- p37
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-25
- Date modifiied:
- 2014-11-19
Related products to: Signal Transduction: UBXN2B, 1-331aa, Human, His tag, E.coli
Related articles to: Signal Transduction: UBXN2B, 1-331aa, Human, His tag, E.coli
- The AAA-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), a major protein unfolding machinery with a variety of essential functions, localizes to different subcellular compartments where it has different functions. However, the processes regulating the distribution of VCP between the cytosol and nucleus are not understood. Here, we identified p37 (also called UBXN2B) as a major factor regulating VCP nucleocytoplasmic shuttling. p37-dependent VCP localization was crucial for local cytosolic VCP functions, such as autophagy, and nuclear functions in DNA damage repair. Mutations in VCP causing multisystem proteinopathy enhanced its association with p37, leading to decreased nuclear localization of VCP, which enhanced susceptibility to DNA damage accumulation. Both VCP localization and DNA damage susceptibility in cells with such mutations were normalized by lowering p37 levels. Thus, we uncovered a mechanism by which VCP nucleocytoplasmic distribution is fine-tuned, providing a means for VCP to respond appropriately to local needs. - Source: PubMed
Publication date: 2024/05/03
Wrobel LidiaHoffmann Johanna LLi XinyiRubinsztein David C - Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The present study aimed to identify the key genes associated with UM metastasis and established a gene signature to analyze the relationship between the signature and prognosis and immune cell infiltration. Later, a predictive model combined with clinical variables was developed and validated. - Source: PubMed
Publication date: 2024/01/21
Wang JianLiu MiaomiaoSun JiaxingZhang Zifeng - The main objective of the current research was to locate, annotate, and highlight specific areas of the bovine genome that are undergoing intense positive selection. Here, we are analyzing selection signatures in crossbred (Bos taurus X Bos indicus), taurine (Bos taurus), and indicine (Bos indicus) cattle breeds. Indicine cattle breeds found throughout India are known for their higher heat tolerance and disease resilience. More breeds and more methods can provide a better understanding of the selection signature. So, we have worked on nine distinct cattle breeds utilizing seven different summary statistics, which is a fairly extensive approach. In this study, we carried out a thorough genome-wide investigation of selection signatures using bovine 50K SNP data. We have included the genotyped data of two taurine, two crossbreds, and five indicine cattle breeds, for a total of 320 animals. During the 1950s, these indicine (cebuine) cattle breeds were exported with the aim of enhancing the resilience of taurine breeds in Western countries. For this study, we employed seven summary statistics, including intra-population, i.e., Tajima's D, CLR, iHS, and ROH and inter-population statistics, i.e., F, XP-EHH, and Rsb. The NCBI database, PANTHER 17.0, and CattleQTL database were used for annotation after finding the important areas under selection. Some genes, including EPHA6, CTNNA2, NPFFR2, HS6ST3, NPR3, KCNIP4, LIPK, SDCBP, CYP7A1, NSMAF, UBXN2B, UGDH, UBE2K, and DAB1, were shown to be shared by three or more different approaches. Therefore, it gives evidence of the most intense selection in these areas. These genes are mostly linked to milk production and adaptability traits. This study also reveals selection regions that contain genes which are crucial to numerous biological functions, including those associated with milk production, coat color, glucose metabolism, oxidative stress response, immunity and circadian rhythms. - Source: PubMed
Publication date: 2023/10/16
Nayak Sonali SonejitaPanigrahi ManjitRajawat DivyaGhildiyal KanikaSharma AnurodhParida SubhashreeBhushan BharatMishra B PDutt Triveni - The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis, and DNA damage repair, and its de-regulation is linked to neuromuscular diseases and cancer. p97 is tightly controlled by numerous regulatory cofactors, but the full range and function of the p97-cofactor network is unknown. Here, we identify the hitherto uncharacterized FAM104 proteins as a conserved family of p97 interactors. The two human family members CP nuclear ofactor amily member 1 and 2 (VCF1/2) bind p97 directly via a novel, alpha-helical motif and associate with p97-UFD1-NPL4 and p97-UBXN2B complexes in cells. VCF1/2 localize to the nucleus and promote the nuclear import of p97. Loss of VCF1/2 results in reduced nuclear p97 levels, slow growth, and hypersensitivity to chemical inhibition of p97 in the absence and presence of DNA damage, suggesting that FAM104 proteins are critical regulators of nuclear p97 functions. - Source: PubMed
Publication date: 2023/09/15
Körner MariaMeyer Susanne RMarincola GabriellaKern Maximilian JGrimm ClemensSchuelein-Voelk ChristinaFischer UtzHofmann KayBuchberger Alexander - This study aimed to identify genetic associations with carcass traits in Hanwoo cattle using a genome-wide association study. A total of 9302 phenotypes were analyzed, and all animals were genotyped using the Illumina Bovine 50K v.3 SNP chip. Heritabilities for carcass weight (CWT), eye muscle area (EMA), backfat thickness (BF), and marbling score (MS) were estimated as 0.42, 0.36, 0.36, and 0.47, respectively, using the GBLUP model, and 0.47, 0.37, 0.36, and 0.42, respectively, using the Bayes B model. We identified 129 common SNPs using DGEBV and 118 common SNPs using GEBV on BTA6, BTA13, and BTA14, suggesting their potential association with the traits of interest. No common SNPs were found between the GBLUP and Bayes B methods when using residuals as a response variable in GWAS. The most promising candidate genes for CWT included , , , , , , , , , , , , , , , , , and . For EMA, the genes , , , , , , and demonstrated significance. Similarly, , , , and were associated with BF, while , , , and were associated with MS. This finding offers valuable insights into genomic regions and molecular mechanisms influencing Hanwoo carcass traits, aiding efficient breeding strategies. - Source: PubMed
Publication date: 2023/08/28
Alam Mohammad ZahangirHaque Md AzizulIqbal AsifLee Yun-MiHa Jae-JungJin ShilPark ByounghoKim Nam-YoungWon Jeong IlKim Jong-Joo