Recombinant Human ADAMTS1, truncated, His-tagged
- Known as:
- Recombinant Human ADAMTS1, truncated, histidine-tagged
- Catalog number:
- 30400403
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- BioTeZ
- Gene target:
- Recombinant Human ADAMTS1 truncated His-tagged
Related genes to: Recombinant Human ADAMTS1, truncated, His-tagged
- Gene:
- ADAMTS1 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 1
- Previous symbol:
- -
- Synonyms:
- C3-C5, METH1, KIAA1346
- Chromosome:
- 21q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-19
- Date modifiied:
- 2015-11-09
- Gene:
- ADAMTS5 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 5
- Previous symbol:
- -
- Synonyms:
- ADMP-2, ADAMTS11
- Chromosome:
- 21q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-23
- Date modifiied:
- 2015-11-09
- Gene:
- ADAMTS16 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 16
- Previous symbol:
- -
- Synonyms:
- ADAMTS16s
- Chromosome:
- 5p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-13
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human ADAMTS1, truncated, His-tagged
Related articles to: Recombinant Human ADAMTS1, truncated, His-tagged
- Prostaglandins (PGs) are a class of fatty-acid derived hormones that are essential in ovulation of teleosts, but their exact role remains unknown. One putative target of PGs in ovulation is regulation of the expression of members of the A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) family, which are implicated in follicular rupture. This study investigated the regulation of ADAMTS, other proteases, and their inhibitors in response to treatment with PGE or PGF. Four members of the ADAMTS family, ADAMTS1, ADAMTS5, ADAMTS9, and ADAMTS16 were shown to be expressed in the ovary of zebrafish, but only adamts1 was upregulated in full-grown follicles following treatment with PGE. Inhibitors of the PG receptors EP1 and EP2 had no effect on PGE-stimulated adamts1 expression, while treatment of full-grown follicles with both PGE and GW627368x, an inhibitor of EP4 function, prevented the PGE-induced increase in adamts1 expression. Treatment of full-grown follicles with the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17,20β-P) in vitro had no effect on the expression of adamts1 mRNA. These findings suggest that expression of ADAMTS1 in zebrafish ovarian follicles is regulated by the prostaglandin PGE via the EP4 series prostaglandin receptor. - Source: PubMed
Publication date: 2021/06/26
Baker Sheridan J CVan Der Kraak Glen - Disintegrin-like and Metalloproteinase with Thrombospondin Motifs (ADAMTS) proteins that are fundamentally located in the extracellular matrix (ECM) have critical roles on different cellular processes by altering the ECM architecture. It has been known that expression of some members of these proteinases increases in aneurismal and dissectional aortic tissue. The purpose of this study is to investigate ADAMTS1, 5, 16 and tissue inhibitors of metalloproteinases-1, -2 (TIMP-1, -2) levels in aortic tissue obtained from patients with thoracic aortic aneurysms and dissections and to achieve new insights about the function of ADAMTS family members. - Source: PubMed
Güneş Mahmut FatihAkpinar Mehmet BeşirCömertoğlu IsmailAkyol SümeyyaDemirçelik BoraGürel Özgül MalçokAynekin BüşraErdemli Haci KemalAteş MehmetEryonucu BeyhanDemircan Kadir - Aggrecanases from the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family are important therapeutic targets due to their essential role in aggrecan depletion in arthritic diseases. Whether their function is also important for matrix rearrangements during chondrogenesis and thus, cartilage regeneration, is however so far unknown. The aim of this study was to analyse the expression and function of ADAMTS with aggrecanase activity during chondrogenic differentiation of human mesenchymal stem cells (MSCs). Chondrogenic differentiation was induced in bone marrow-derived MSC pellets and expression of COL2A1, aggrecan, ADAMTS1, 4, 5, 9, 16 and furin was followed by quantitative RT-PCR. Formation of the NITEGE (ADAMTS-cleaved) and DIPEN (MMP-cleaved) aggrecan neoepitopes was detected by immunohistochemistry. While the expression of ADAMTS4, 9, 16 and furin was up-regulated during chondrogenesis, ADAMTS1 and 5 were down-regulated. Despite this regulation of ADAMTS, no formation of NITEGE neoepitopes occurred in MSC pellets, indicating no ADAMTS-induced cleavage of aggrecan. In contrast, MMP-induced cleavage of aggrecan appeared at 14 d after induction of chondrogenesis. Submission of differentiated MSC pellets to IL1β treatment for 3 d resulted in strong upregulation of ADAMTS1, 4 and 5, rapid proteoglycan depletion, and stimulation of ADAMTS-induced but not MMP-induced cleavage of aggrecan. Thus, there is no evidence for ADAMTS-induced aggrecan cleavage during chondrogenesis, but proteoglycan turnover is rapidly inducible under inflammatory signals. Therapeutic aggrecanase inhibition for treatment of arthritic disease may thus not impede regenerative self-healing pathways based on chondrogenesis of local progenitor cells in the joint. - Source: PubMed
Publication date: 2012/05/04
Boeuf SGraf FFischer JMoradi BLittle C BRichter W - To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA). - Source: PubMed
Kevorkian LaraYoung David ADarrah ClareDonell Simon TShepstone LeePorter SarahBrockbank Sarah M VEdwards Dylan RParker Andrew EClark Ian M