R 340 Cond Meter set for low conductivity measurement. Professional portable conductivity meter with automatic calibration, Auto_Read drift control function, full GLP functions _ realtime clock, dat
- Known as:
- R 340 Cond Meter set low conductivity measurement. Professional portable conductivity meter automatic calibration, Auto_Read drift reference function, GLP functions _ realtime clock, dat
- Catalog number:
- 340CSETLOW
- Product Quantity:
- Kit
- Category:
- -
- Supplier:
- Reagecon
- Gene target:
- 340 Cond Meter set for low conductivity measurement. Professional portable meter with automatic calibration Auto_Read drift control function full GLP functions _ realtime clock dat
Related genes to: R 340 Cond Meter set for low conductivity measurement. Professional portable conductivity meter with automatic calibration, Auto_Read drift control function, full GLP functions _ realtime clock, dat
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: R 340 Cond Meter set for low conductivity measurement. Professional portable conductivity meter with automatic calibration, Auto_Read drift control function, full GLP functions _ realtime clock, dat
Related articles to: R 340 Cond Meter set for low conductivity measurement. Professional portable conductivity meter with automatic calibration, Auto_Read drift control function, full GLP functions _ realtime clock, dat
- Although the world is acquitting from the throes of COVID-19 and returning to the regularity of life, its effects on physical and mental health are prominently evident in the post-pandemic era. The pandemic subjected us to inadequate sleep and physical activities, stress, irregular eating patterns, and work hours beyond the regular rest-activity cycle. Thus, perturbing the synchrony of the regular circadian clock functions led to chronic psychiatric and neurological disorders and poor immunological response in several COVID-19 survivors. Understanding the links between the host immune system and viral replication machinery from a clock-infection biology perspective promises novel avenues of intervention. Behavioral improvements in our daily lifestyle can reduce the severity and expedite the convalescent stage of COVID-19 by maintaining consistent eating, sleep, and physical activity schedules. Including dietary supplements and nutraceuticals with prophylactic value aids in combating COVID-19, as their deficiency can lead to a higher risk of infection, vulnerability, and severity of COVID-19. Thus, besides developing therapeutic measures, perpetual healthy practices could also contribute to combating the upcoming pandemics. This review highlights the impact of the COVID-19 pandemic on biological rhythms, sleep-wake cycles, physical activities, and eating patterns and how those disruptions possibly contribute to the response, severity, and outcome of SARS-CoV-2 infection. - Source: PubMed
Publication date: 2024/05/03
Das SandipKhan RajniBanerjee SrishtiRay ShashikantRay Sandipan - - Source: PubMed
Publication date: 2024/05/03
Christiani David C - In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain signals to ensure timely execution of epidermal daily physiology. Timely cell-cycle termination in the epidermal stem cell compartment depends upon incorporation of clock-driven signals originating from the brain. In contrast, the epidermal clock corrects or outcompetes potentially disruptive feeding-related signals to ensure the optimal timing of DNA replication. Together, we present an approach for cataloging the systemic dependencies of daily temporal organization in a tissue and identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis. - Source: PubMed
Publication date: 2024/04/27
Mortimer ThomasZinna Valentina MAtalay MugeLaudanna CarmeloDeryagin OlegPosas GuillemSmith Jacob GGarcía-Lara ElisaVaca-Dempere MireiaMonteiro de Assis Leonardo ViníciusHeyde IsabelKoronowski Kevin BPetrus PaulGreco Carolina MForrow StephenOster HenrikSassone-Corsi PaoloWelz Patrick-SimonMuñoz-Cánoves PuraBenitah Salvador Aznar - Antibody-based therapy depletes myeloid-biased hematopoietic stem cells (my-HSCs) to rejuvenate the immune system and improve immune responses in aged mice. - Source: PubMed
Publication date: 2024/05/03
Conde LucianaLucas Carolina - Plant growth occurs via the interconnection of cell growth and proliferation in each organ following specific developmental and environmental cues. Therefore, different photoperiods result in distinct growth patterns due to the integration of light and circadian perception with specific Carbon (C) partitioning strategies. In addition, the TARGET OF RAPAMYCIN (TOR) kinase pathway is an ancestral signaling pathway that integrates nutrient information with translational control and growth regulation. Recent findings in Arabidopsis (Arabidopsis thaliana) have shown a mutual connection between the TOR pathway and the circadian clock. However, the mechanistical network underlying this interaction is mostly unknown. Here, we show that the conserved TOR target, the 40S ribosomal protein S6 kinase (S6 K) is under circadian and photoperiod regulation both at the transcriptional and post-translational level. Total S6 K (S6K1 and S6K2) and TOR-dependent phosphorylated-S6 K protein levels were higher during the light period and decreased at dusk especially under short day conditions. Using chemical and genetic approaches we found that the diel pattern of S6 K accumulation results from 26S proteasome-dependent degradation and is altered in mutants lacking the circadian F-box protein ZEITLUPE (ZTL), further strengthening our hypothesis that S6 K could incorporate metabolic signals via TOR, which are also under circadian regulation. Moreover, under short days when C/energy levels are limiting, changes in S6K1 protein levels affected starch, sucrose and glucose accumulation and consequently impacted root and rosette growth responses. In summary, we propose that S6K1 constitutes a missing molecular link where day-length perception, nutrient availability and TOR pathway activity converge to coordinate growth responses with environmental conditions. - Source: PubMed
Publication date: 2024/05/03
Boix MarcGarcia-Rodriguez AlbaCastillo LaiaMiró BernatHamilton FergaTolak SanataPérez AdriánMonte-Bello CarolinaCaldana CamilaHenriques Rossana