Protein Recombinant Human CAMK2A, GST-tagged, Active
- Known as:
- Protein Recombinant Human CAMK2A, GST-tagged, Active
- Catalog number:
- CAMK2A-264H
- Product Quantity:
- 5μg
- Category:
- -
- Supplier:
- CBio
- Gene target:
- Protein Recombinant Human CAMK2A GST-tagged Active
Related genes to: Protein Recombinant Human CAMK2A, GST-tagged, Active
- Gene:
- CAMK2A NIH gene
- Name:
- calcium/calmodulin dependent protein kinase II alpha
- Previous symbol:
- CAMKA
- Synonyms:
- KIAA0968, CaMKIINalpha
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2016-04-06
Related products to: Protein Recombinant Human CAMK2A, GST-tagged, Active
Related articles to: Protein Recombinant Human CAMK2A, GST-tagged, Active
- - Source: PubMed
Publication date: 2024/04/23
Voide NathalieMacherel ManonRanza Emmanuelle - Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen species and regulates key cellular processes through redox protein-protein interactions. Here, we determine the effect of chronic alcohol consumption on NXN-dependent redox interactions in the liver of aged mice. We found that chronic alcohol consumption preferentially promotes the localization of NXN either into or alongside senescent cells, declines its interacting capability, and worsens the altered interaction ratio of NXN with FLII, MYD88, CAMK2A, and PFK1 proteins induced by aging. In addition, carbonylated protein and cell proliferation increased, and the ratios of collagen I and collagen III were inverted. Thus, we demonstrate an emerging phenomenon associated with altered redox homeostasis during aging, as shown by the declining capability of NXN to interact with partner proteins, which is enhanced by chronic alcohol consumption in the mouse liver. This evidence opens an attractive window to elucidate the consequences of both aging and chronic alcohol consumption on the downstream signaling pathways regulated by NXN-dependent redox-sensitive interactions. - Source: PubMed
Publication date: 2024/02/20
Idelfonso-García Osiris GermánAlarcón-Sánchez Brisa RodopeGuerrero-Escalera DafneLópez-Hernández Norma ArelyPérez-Hernández José LuisPacheco-Rivera RuthSerrano-Luna JesúsResendis-Antonio OsbaldoMuciño-Olmos Erick AndrésAparicio-Bautista Diana IvetteBasurto-Islas GustavoBaltiérrez-Hoyos RafaelVásquez-Garzón Verónica RocíoVilla-Treviño SaúlMuriel PabloSerrano HéctorPérez-Carreón Julio IsaelArellanes-Robledo Jaime - Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, PTSD, dementia, and age-related cognitive decline. While BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis (AHN), its significance as a pharmacological target has not been tested. - Source: PubMed
Publication date: 2024/02/04
Chang Wei-LiTegang KarlySamuels Benjamin ASaxe MichaelWichmann JuergenDavid Denis JDavid Indira MendezAugustin AngéliqueFischer HolgerGolling SabrinaLamerz JensRoth DorisGraf MartinZoffmann SannahSantarelli LucaJagasia RaviHen René - The nasal cavity harbors diverse microbiota that contributes to human health and respiratory diseases. However, whether and to what extent the host genome shapes the nasal microbiome remains largely unknown. Here, by dissecting the human genome and nasal metagenome data from 1401 healthy individuals, we demonstrated that the top three host genetic principal components strongly correlated with the nasal microbiota diversity and composition. The genetic association analyses identified 63 genome-wide significant loci affecting the nasal microbial taxa and functions, of which 2 loci reached study-wide significance (p < 1.7 × 10): rs73268759 within CAMK2A associated with genus Actinomyces and family Actinomycetaceae; and rs35211877 near POM121L12 with Gemella asaccharolytica. In addition to respiratory-related diseases, the associated loci are mainly implicated in cardiometabolic or neuropsychiatric diseases. Functional analysis showed the associated genes were most significantly expressed in the nasal airway epithelium tissue and enriched in the calcium signaling and hippo signaling pathway. Further observational correlation and Mendelian randomization analyses consistently suggested the causal effects of Serratia grimesii and Yokenella regensburgei on cardiometabolic biomarkers (cystine, glutamic acid, and creatine). This study suggested that the host genome plays an important role in shaping the nasal microbiome. - Source: PubMed
Publication date: 2024/01/30
Liu XiaominTong XinZou LeyingJu YanmeiLiu MingliangHan MoLu HaorongYang HuanmingWang JianZong YangLiu WeibinXu XunJin XinXiao LiangJia HuijueGuo RuijinZhang Tao - The calcium/calmodulin-dependent protein kinase type 2 (CAMK2) family consists of four different isozymes, encoded by four different genes-CAMK2A, CAMK2B, CAMK2G, and CAMK2D-of which the first three have been associated recently with neurodevelopmental disorders. CAMK2D is one of the major CAMK2 proteins expressed in the heart and has been associated with cardiac anomalies. Although this CAMK2 isoform is also known to be one of the major CAMK2 subtypes expressed during early brain development, it has never been linked with neurodevelopmental disorders until now. Here we show that CAMK2D plays an important role in neurodevelopment not only in mice but also in humans. We identified eight individuals harboring heterozygous variants in CAMK2D who display symptoms of intellectual disability, delayed speech, behavioral problems, and dilated cardiomyopathy. The majority of the variants tested lead to a gain of function (GoF), which appears to cause both neurological problems and dilated cardiomyopathy. In contrast, loss-of-function (LoF) variants appear to induce only neurological symptoms. Together, we describe a cohort of individuals with neurodevelopmental disorders and cardiac anomalies, harboring pathogenic variants in CAMK2D, confirming an important role for the CAMK2D isozyme in both heart and brain function. - Source: PubMed
Publication date: 2024/01/24
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