PA_FB_W w_o cap1
- Known as:
- PA_FB_W w_o cap1
- Catalog number:
- 233485
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Herolab
- Gene target:
- PA_FB_W w_o cap1
Related genes to: PA_FB_W w_o cap1
- Gene:
- CAP1 NIH gene
- Name:
- cyclase associated actin cytoskeleton regulatory protein 1
- Previous symbol:
- -
- Synonyms:
- CAP
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-17
- Date modifiied:
- 2017-05-17
Related products to: PA_FB_W w_o cap1
Adenylyl Cyclase Associated Protein 1 (CAP1) Organism: Homo sapiens (Human) Source: Escherichia coliAdenylyl Cyclase Associated Protein 1 (CAP1) Organism: Homo sapiens (Human) Source: Escherichia coliAdenylyl Cyclase Associated Protein 1 (CAP1) Organism: Homo sapiens (Human) Source: Escherichia coliAdenylyl cyclase-associated protein 1,ASP-56 protein,CAP,CAP 1,CAP1,Pig,Sus scrofaAdenylyl cyclase-associated protein 1,Bos taurus,Bovine,CAP 1,CAP1Adenylyl cyclase-associated protein 1,CAP,CAP 1,CAP1,Homo sapiens,HumanAdenylyl cyclase-associated protein 1,Cap,CAP 1,Cap1,Mch1,Rat,Rattus norvegicusAdenylyl cyclase-associated protein 1,Cap,CAP 1,Cap1,Mouse,Mus musculusAnserine Adenylyl Cyclase Associated Protein 1 Elisa Kit (CAP1)Anserine anti - Adenylyl Cyclase Associated Protein 1 Elisa Kit (CAP1)anti-CAP1anti-CAP1anti-CAP1anti-CAP1anti-CAP1 Related articles to: PA_FB_W w_o cap1
- Serum response factor (SRF) is an essential transcription factor for brain development and function. Here, we explored how an SRF cofactor, the actin monomer-sensing myocardin-related transcription factor MRTF, is regulated in mouse cortical neurons. We found that MRTF-dependent SRF activity in vitro and in vivo was repressed by cyclase-associated protein CAP1. Inactivation of the actin-binding protein CAP1 reduced the amount of actin monomers in the cytoplasm, which promoted nuclear MRTF translocation and MRTF-SRF activation. This function was independent of cofilin1 and actin-depolymerizing factor, and CAP1 loss of function in cortical neurons was not compensated by endogenous CAP2. Transcriptomic and proteomic analyses of cerebral cortex lysates from wild-type and knockout mice supported the role of CAP1 in repressing MRTF-SRF-dependent signaling in vivo. Bioinformatic analysis identified likely MRTF-SRF target genes, which aligned with the transcriptomic and proteomic results. Together with our previous studies that implicated CAP1 in axonal growth cone function as well as the morphology and plasticity of excitatory synapses, our findings establish CAP1 as a crucial actin regulator in the brain relevant for formation of neuronal networks. - Source: PubMed
Publication date: 2024/05/07
Khudayberdiev SharofWeiss KerstinHeinze AnikaColombaretti DalilaTrausch NathanLinne UweRust Marco B - Cardiovascular disease (CVD) is the leading cause of death in rheumatoid arthritis (RA). Resistin is an adipokine that induces adipose tissue inflammation and activation of monocytes/macrophages via adenylate cyclase-associated protein-1 (CAP1). Resistin levels are increased in RA and might cause perivascular adipose tissue (PVAT) dysfunction, leading to vascular damage and CVD. This study aimed to investigate the role of resistin in promoting PVAT dysfunction by increasing local macrophage and inflammatory cytokines content in antigen-induced arthritis (AIA). Resistin pharmacological effects were assessed by using C57Bl/6J wild-type (WT) mice, humanized resistin mice expressing human resistin in monocytes-macrophages (hRTN//), and resistin knockout mice (RTN/) with AIA and respective controls. We investigated AIA disease activity and functional, cellular, and molecular parameters of the PVAT. Resistin did not contribute to AIA disease activity and its concentrations were augmented in the PVAT and plasma of WT AIA and hRTN// AIA animals. In vitro exposure of murine arteries to resistin impaired vascular function by decreasing the anti-contractile effect of PVAT. WT AIA mice and hRTN// AIA mice exhibited PVAT dysfunction and knockdown of resistin prevented it. Macrophage-derived cytokines, markers of types 1 and 2 macrophages, and CAP1 expression were increased in the PVAT of resistin humanized mice with AIA, but not in knockout mice for resistin. This study reveals that macrophage-derived resistin promotes PVAT inflammation and dysfunction regardless of AIA disease activity. Resistin might represent a translational target to reduce RA-driven vascular dysfunction and CVD. - Source: PubMed
Publication date: 2024/04/28
Fedoce Aline GVeras Flávio PRosa Marcos HSchneider Ayda HPaiva Isadora MMachado Mirele RFreitas-Filho Edismauro GSilva Josiane FMachado Caio CAlves-Filho José CCunha Fernando QN Z Ramalho LeandraLouzada-Junior PauloBonavia Anthony STostes Rita C - The sustainability of the food system needs to be improved, including shortening supply chains and promoting the consumption of regional food. Here, we explore the current potential for regional food self-sufficiency in the European Alpine space by calculating the current regional food/feed energy balance, deriving the regional per capita land footprint based on current food/feed consumption rates, and modelling the current potential for regional food/feed self-sufficiency. We show that 59% of the 560 Pcal of energy currently available in the study area comes from domestic production, and almost 60% of the energy is used for livestock consumption, with high regional variability. The resulting land footprints range from 2301 to 2975 m cap y. Taking into account changes in cropping patterns, partial intensification, but no expansion of agricultural land, the European Alpine space could produce 89% of its current food demand domestically, with high regional variability due to population density, availability of agricultural land, crop yields, climatic conditions and dietary habits. These findings highlight the potential and limitations of regional mountain food systems and call for new strategies to improve sustainability. Reducing the current high consumption of animal products would reduce the land footprint and increase the potential for food self-sufficiency. - Source: PubMed
Publication date: 2024/04/25
Pecher CarolineMarsoner ThomasTasser Erich - Actin filaments and their associated actin-binding proteins (ABPs) play key roles in plant innate immune signaling. CAP1, or cyclase-associated protein 1, is an important regulatory factor of the actin cytoskeleton-associated signaling network, and was hypothesized here to be involved in resistance against wheat stripe rust because TaCAP1 expression was up-regulated in response to Puccinia striiformis f. sp. tritici (Pst). Down regulation of TaCAP1 expression led to decreased resistance against Pst, in contrast to increased resistance upon TaCAP1 overexpressing, as demonstrated by the changes of phenotypes and hyphal growth. We found increased expression of pathogenesis-responsive or relative related genes and disease grade changed in TaCAP1 overexpressing plants. Our results also showed TaCAP1-regulated host resistance to Pst by inducing the production and accumulation of reactive oxygen species (ROS) and mediating the salicylic acid signaling pathway. Additionally, TaCAP1 interacted with chlorophyll a/b -binding proteins TaLHCB1.3 and TaLHCB1.4, also known as light-harvesting chlorophyll-protein complex II subunit B (LHCB), which belong to the light-harvesting complex II proteins family. Silencing of two TaLHCB1 genes showed higher susceptibility to Pst, which reduced wheat resistance against Pst. Therefore, the data presented herein further illuminate our understanding that TaCAP1 interacts with TaLHCB1s, and functions as a positive regulator of wheat resistance against the stripe rust. - Source: PubMed
Publication date: 2024/04/22
Shi BeibeiLian QingguiGao HaifengWang YangMa Qing - Neoantigen (neoAg)-based cancer vaccines expand preexisting antitumor immunity and elicit novel cancer-specific T cells. However, at odds with prophylactic vaccines, therapeutic antitumor immunity must be induced when the tumor is present and has already established an immunosuppressive environment capable of rapidly impairing the function of anticancer neoAg T cells, thereby leading to lack of efficacy. To overcome tumor-induced immunosuppression, we first vaccinated mice bearing immune checkpoint inhibitor (CPI)-resistant tumors with an adenovirus vector encoding a set of potent cancer-exogenous CD8 and CD4 T cell epitopes (Ad-CAP1), and then "taught" cancer cells to express the same epitopes by using a tumor-retargeted herpesvirus vector (THV-CAP1). Potent CD8 effector T lymphocytes were elicited by Ad-CAP1, and subsequent THV-CAP1 delivery led to a significant delay in tumor growth and even cure. - Source: PubMed
Publication date: 2024/01/10
Troise FulviaLeoni GuidoSasso EmanueleDel Sorbo MariarosariaEsposito MarialuisaRomano GiuseppinaAllocca SimonaFroechlich GuendalinaCotugno GabriellaCapone StefaniaFolgori AntonellaScarselli ElisaD'Alise Anna MorenaNicosia Alfredo