ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Known as:
- Enzyme-linked immunosorbent assay test AGTR1,Angiotensin II classification-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Catalog number:
- E1658Rb
- Product Quantity:
- 96T
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- ELISA AGTR1 Angiotensin type-1 receptor AT1 Oryctolagus cuniculus Rabbit Type-1 angiotensin
Ask about this productRelated genes to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Gene:
- AGTR1 NIH gene
- Name:
- angiotensin II receptor type 1
- Previous symbol:
- AGTR1B
- Synonyms:
- AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2017-07-07
Related products to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
Related articles to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Atopic dermatitis (AD), psoriasis (PS), and inflammatory acne (IA) are well-known as inflammatory skin diseases. Studies of the transcriptome with altered expression levels have reported a large number of dysregulated genes and gene clusters, particularly those involved in inflammatory skin diseases. - Source: PubMed
Publication date: 2024/05/17
Wang WeiHwang SungboPark DaeuiPark Yong Doo - Brown adipocytes are potential therapeutic targets for the prevention of obesity-associated metabolic diseases because they consume circulating glucose and fatty acids for heat production. Angiotensin II (Ang II) peptide is involved in the pathogenesis of obesity- and cold-induced hypertension; however, the mechanism underlying the direct effects of Ang II on human brown adipocytes remains unclear. Our transcriptome analysis of chemical compound-induced brown adipocytes (ciBAs) showed that the Ang II type 1 receptor (AGTR1), but not AGTR2 and MAS1 receptors, was expressed. The Ang II/AGTR1 axis downregulated the expression of mitochondrial uncoupling protein 1 (UCP1). The simultaneous treatment with β-adrenergic receptor agonists and Ang II attenuated UCP1 expression, triglyceride lipolysis, and cAMP levels, although cAMP response element-binding protein (CREB) phosphorylation was enhanced by Ang II mainly through the protein kinase C pathway. Despite reduced lipolysis, both coupled and uncoupled mitochondrial respiration was enhanced in Ang II-treated ciBAs. Instead, glycolysis and glucose uptake were robustly activated upon treatment with Ang II without a comprehensive transcriptional change in glucose metabolic genes. Elevated mitochondrial energy status induced by Ang II was likely associated with UCP1 repression. Our findings suggest that the Ang II/AGTR1 axis participates in mitochondrial thermogenic functions via glycolysis. - Source: PubMed
Publication date: 2024/05/11
Takeda YukimasaYoshikawa ToshikazuDai Ping - To analyze the gene variants of the renin-angiotensin-aldosterone system and determine their association with the severity and outcome of COVID-19. - Source: PubMed
Publication date: 2024/04/30
Martinez-Fierro Margarita LPerez-Favila AurelioZorrilla-Alfaro Sidere MOropeza-de Lara Sergio AGarza-Veloz IdaliaHernandez-Marquez Lucia Del SGutierrez-Vela Edgar FDelgado-Enciso IvanRodriguez-Sanchez Iram P - Despite advancements in colorectal cancer (CRC) treatment, the prognosis remains unfavorable for patients with distant liver metastasis. Fluorescence molecular imaging with specific probes is increasingly used to guide CRC surgical resection in real-time and treatment planning. Here, we demonstrate the targeted imaging capacity of an MPA-PEG-N-Ang II probe labeled with near-infrared (NIR) fluorescent dye targeting the angiotensin II (Ang II) type 1 receptor (AGTR1) that is significantly upregulated in CRC. MPA-PEG-N-Ang II was highly selective and specific to in vitro tumor cells and in vivo tumors in a mouse CRC xenograft model. The favorable ex vivo imaging and in vivo biodistribution of MPA-PEG-N-Ang II afforded tumor-specific accumulation with low background and >10 contrast tumor-to-colorectal values in multiple subcutaneous CRC models at 8 h following injection. Biodistribution analysis confirmed the probe's high uptake in HT29 and HCT116 orthotopic and liver metastatic models of CRC with signal-to-noise ratio (SNR) values of tumor-to-colorectal and -liver fluorescence of 5.8 ± 0.6, 5.3 ± 0.7, and 2.7 ± 0.5, 2.6 ± 0.5, respectively, enabling high-contrast intraoperative tumor visualization for surgical navigation. Given its rapid tumor targeting, precise tumor boundary delineation, durable tumor retention and docking study, MPA-PEG-N-Ang II is a promising high-contrast imaging agent for the clinical detection of CRC. - Source: PubMed
Publication date: 2024/04/27
Zhou KunchengLi GangPan RongbinXin SulinWen WeijieWang HuiyiLuo ChaoHan Ray P SGu YueqingTu Yuanbiao - Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification. - Source: PubMed
Publication date: 2024/04/22
Al-Maraghi AljaziAamer WaleedZiab MubarakAliyev ElbayElbashir NajwaHussein SuraPalaniswamy SasirekhaAnand DhullipalaLove Donald RCharles AdrianA S Akil AmmiraFakhro Khalid A