Mouse Protein Tyrosine Phosphatase Receptor Type B ELISA,PTPRB
- Known as:
- Mouse Protein Tyrosine Phosphatase Receptor Type B Enzyme-linked immunosorbent assay test,PTPRB
- Catalog number:
- E03P0168
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Mouse Protein Tyrosine Phosphatase Receptor Type ELISA PTPRB
Related genes to: Mouse Protein Tyrosine Phosphatase Receptor Type B ELISA,PTPRB
- Gene:
- PTPRB NIH gene
- Name:
- protein tyrosine phosphatase receptor type B
- Previous symbol:
- PTPB
- Synonyms:
- -
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 1991-05-15
- Date modifiied:
- 2019-02-14
Related products to: Mouse Protein Tyrosine Phosphatase Receptor Type B ELISA,PTPRB
Related articles to: Mouse Protein Tyrosine Phosphatase Receptor Type B ELISA,PTPRB
- Central Serous Chorioretinopathy (CSCR) manifests as fluid accumulation between the neurosensory retina and the retinal pigment epithelium (RPE). Elevated levels of steroid hormones have been implicated in CSCR pathogenesis. This investigation aims to delineate the gene expression patterns of CSCR-associated risk and steroid receptors across human choroidal cell types and RPE cells to discern potential underlying mechanisms. - Source: PubMed
Publication date: 2024/01/24
Künzel Sandrine HPohlmann DominikaBonsen Lynn ZurKrappitz MatteusZeitz OliverJoussen Antonia MDubrac AlexandreKünzel Steffen E - Endothelial cells of mammalian blood vessels have multiple levels of heterogeneity along the vascular tree and among different organs. Further heterogeneity results from blood flow turbulence and variations in shear stress. In the aorta, vascular endothelial protein tyrosine phosphatase (VE-PTP), which dephosphorylates tyrosine kinase receptor Tie2 in the plasma membrane, undergoes downstream polarization and endocytosis in endothelial cells exposed to laminar flow and high shear stress. VE-PTP sequestration promotes Tie2 phosphorylation at tyrosine992 and endothelial barrier tightening. The present study characterized the heterogeneity of VE-PTP polarization, Tie2-pY992 and total Tie2, and claudin-5 in anatomically defined regions of endothelial cells in the mouse descending thoracic aorta, where laminar flow is variable and IgG extravasation is patchy. We discovered that VE-PTP and Tie2-pY992 had mosaic patterns, unlike the uniform distribution of total Tie2. Claudin-5 at tight junctions also had a mosaic pattern, whereas VE-cadherin at adherens junctions bordered all endothelial cells. Importantly, the amounts of Tie2-pY992 and claudin-5 in aortic endothelial cells correlated with downstream polarization of VE-PTP. VE-PTP and Tie2-pY992 also had mosaic patterns in the vena cava, but claudin-5 was nearly absent and extravasated IgG was ubiquitous. Correlation of Tie2-pY992 and claudin-5 with VE-PTP polarization supports their collective interaction in the regulation of endothelial barrier function in the aorta, yet differences between the aorta and vena cava indicate additional flow-related determinants of permeability. Together, the results highlight new levels of endothelial cell functional mosaicism in the aorta and vena cava, where blood flow dynamics are well known to be heterogeneous. - Source: PubMed
Publication date: 2023/11/30
Baluk PeterShirakura KeisukeVestweber DietmarMcDonald Donald M - The role of mitophagy in various cancer-associated biological processes is well recognized. Nonetheless, the comprehensive implications of mitophagy in clear cell renal cell carcinoma (ccRCC) necessitate further exploration. - Source: PubMed
Publication date: 2023/09/09
Xiang JianfengLiu WangruiLiu ShifanWang TaoTang HaidanYang Jianfeng - Myeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently misdiagnosed because of its non-specific imaging and histological pattern. - Source: PubMed
Publication date: 2023/03/04
Li XiangZhang HongxiaCui YongZhang HaijunWang YonggangDing MeiliZhu XingyaoZhang RuiqiHu QiTao LinHu WenhaoLi XinxiaAo QilinZou Hong - Compelling evidence has demonstrated the critical role of circular RNAs (circRNAs) during lung adenocarcinoma (LUAD) progression. Herein, we explored a novel circRNA, circ_0129047, and detailed its mechanism of action. The expression of circ 0129047, microRNA-665 (miR-665), and protein tyrosine phosphatase receptor type B (PTPRB) in LUAD tissues and cells was determined using reverse transcription quantitative polymerase chain reaction and Western blotting. Cell Counting Kit-8 and colony formation assays were conducted to detect LUAD cell proliferation, and western blotting was performed to quantify apoptosis-related proteins (Bcl-2 and Bax). Luciferase reporter and RNA immunoprecipitation assays were used to validate the predicted interaction between miR-665 and circ_0129047 or PTPRB. A xenograft assay was used for the experiments. Circ_0129047 and PTPRB were downregulated in LUAD tissues and cells, whereas miR-665 expression was upregulated. Overexpression of circ_0129047 suppresses LUAD growth and . Circ_0129047 is the target of miR-665, and the miR-665 mimic ablated the antiproliferative and pro-apoptotic phenotypes of LUAD cells by circ_0129047 augmentation. MiR-665 targets the 3'UTR of PTPRB and downregulates PTPRB expression. PTPRB overexpression offsets the pro-proliferative potential of miR-665 in LUAD cells. Circ_0129047 sequestered miR-665 and upregulated PTPRB expression, thereby reducing LUAD progression, suggesting a promising approach for preventing LUAD. - Source: PubMed
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