Human serine protease ELISA Kit
- Known as:
- Human serine protease Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E1537h
- Product Quantity:
- 96T
- Category:
- Peptides
- Supplier:
- EIAab
- Gene target:
- Human serine protease ELISA Kit
Related genes to: Human serine protease ELISA Kit
- Gene:
- HTRA1 NIH gene
- Name:
- HtrA serine peptidase 1
- Previous symbol:
- PRSS11
- Synonyms:
- HtrA, IGFBP5-protease, ARMD7
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: Human serine protease ELISA Kit
Related articles to: Human serine protease ELISA Kit
- HtrA1, HtrA2, HtrA3 and HtrA4 appear to be involved in the development of pathologies such as cancer. This systematic review reports the results of a literature search performed to compare the expression of HtrA family genes and proteins in cancer versus non-cancer tissues and cell lines, assess relationships between HtrA expression and cancer clinical features in cancer, and analyse the molecular mechanism, by which HtrA family affects cancer. - Source: PubMed
Publication date: 2024/05/08
Rosochowicz Monika AnnaKulcenty KatarzynaSuchorska Wiktoria Maria - : Circular RNAs (circRNAs) have been shown to be extensively involved in preeclampsia progression. At present, the role of circ_0007445 in preeclampsia progression is not clear. - Source: PubMed
Publication date: 2024/02/26
Shao WenjiaCui JinquanWang Wuliang - Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these changes. We analyzed astrocyte gene profiles in the nucleus accumbens (NAc) of humans with MDD and mice exposed to chronic stress. , which encodes an astrocyte-secreted protease targeting the extracellular matrix (ECM), was significantly downregulated in the NAc of males but upregulated in females in both species. Manipulating in mouse NAc astrocytes bidirectionally controlled stress susceptibility in a sex-specific manner. Such manipulations also altered neuronal signaling and ECM structural integrity in NAc. These findings highlight astroglia and the brain's ECM as key mediators of sex-specific stress vulnerability, offering new approaches for MDD therapies. - Source: PubMed
Publication date: 2024/04/15
Parise Eric MGyles Trevonn MGodino ArthurSial Omar KBrowne Caleb JParise Lyonna FTorres-Berrío AngélicaSalery MarineDurand-de Cuttoli RomainRivera Matthew TCardona-Acosta Astrid MHolt LeanneMarkovic Tamaravan der Zee Yentl YLorsch Zachary SCathomas FlurinGaron Juliet BTeague CollinIssler OrnaHamilton Peter JBolaños-Guzmán Carlos ARusso Scott JNestler Eric J - High temperature requirement A1 (HTRA1) is a member of the serine protease family, comprising four structural domains: IGFBP domain, Kazal domain, protease domain and PDZ domain. HTRA1 encodes a serine protease, a secreted protein that is widely expressed in the vasculature. HTRA1 regulates a wide range of physiological processes through its proteolytic activity, and is also involved in a variety of vascular abnormalities-related diseases. This article reviews the role of HTRA1 in the development of vascular abnormalities-related hereditary cerebral small vessel disease (CSVD), age-related macular degeneration (AMD), tumors and other diseases. Through relevant research advances to understand the role of HTRA1 in regulating signaling pathways or refolding, translocation, degradation of extracellular matrix (ECM) proteins, thus directly or indirectly regulating angiogenesis, vascular remodeling, and playing an important role in vascular homeostasis, further understanding the mechanism of HTRA1's role in vascular abnormality-related diseases is important for HTRA1 to be used as a therapeutic target in related diseases. - Source: PubMed
Publication date: 2024/04/18
Song ShinaLi XiaofengXue XutingDong WenpingLi Changxin - The purpose of this study was to determine if levels of the HtrA1 protein in serum or vitreous humor are influenced by genetic risk for age-related macular degeneration (AMD) at the 10q26 locus, age, sex, AMD status, and/or AMD disease severity, and, therefore, to determine the contribution of systemic and ocular HtrA1 to the AMD disease process. - Source: PubMed
Williams Brandi LZouache Moussa ASeager Nathan APappas Chris MLiu JinAnstadt Robert AHubbard William CThomas JulieHageman Jill LMohler JenniferRichards Burt THageman Gregory S