Human IgG2 (gamma_2 chain specific)
- Known as:
- Human IgG2 (gamma_2 epitope specific)
- Catalog number:
- AM08152RP-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Human IgG2 (gamma_2 chain specific)
Related genes to: Human IgG2 (gamma_2 chain specific)
- Gene:
- EIF2S3B NIH gene
- Name:
- eukaryotic translation initiation factor 2 subunit gamma B
- Previous symbol:
- -
- Synonyms:
- eIF2gA, eIF-2-gamma2
- Chromosome:
- 12p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2017-11-30
- Date modifiied:
- 2017-11-30
- Gene:
- FCGRT NIH gene
- Name:
- Fc fragment of IgG receptor and transporter
- Previous symbol:
- -
- Synonyms:
- FCRN, alpha-chain
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1995-08-23
- Date modifiied:
- 2016-10-05
- Gene:
- TMED5 NIH gene
- Name:
- transmembrane p24 trafficking protein 5
- Previous symbol:
- -
- Synonyms:
- CGI-100, p24g2, p24gamma2
- Chromosome:
- 1p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-21
- Date modifiied:
- 2015-08-11
Related products to: Human IgG2 (gamma_2 chain specific)
Related articles to: Human IgG2 (gamma_2 chain specific)
- Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease with humoral and cellular autoimmunity causing demyelination of peripheral nerves, commonly treated with intravenous immunoglobulins (IVIg). The neonatal Fc receptor (FcRn), encoded by the FCGRT gene, prevents the degradation of immunoglobulin G (IgG) by recycling circulating IgG. A variable number of tandem repeat (VNTR) polymorphism in the promoter region of the FCGRT gene is associated with different expression levels of mRNA and protein. Thus, patients with genotypes associated with relatively low FcRn expression may show a poorer treatment response to IVIg due to increased IVIg degradation. - Source: PubMed
Publication date: 2024/01/11
Fisse Anna LenaSchäfer EmelieHieke AlinaSchröder MaximilianKlimas RafaelBrünger JilHuckemann SophieGrüter ThomasSgodzai MelissaSchneider-Gold ChristianeGold RalfNguyen Huu PhucPitarokoili KalliopiMotte JeremiasArning Larissa - High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown. Here, we evaluate in four murine models and across multiple antibodies whether altered baseline catabolic clearance of administered antibody requires a tumor and/or cachexia and whether medical reversal of cachexia phenotype can alleviate altered clearance. Key findings include mild cachexia phenotype and lack of elevated pembrolizumab clearance in the MC38 tumor-bearing model. We also observed severe cachexia and decreased, instead of increased, baseline pembrolizumab clearance in the tumor-free cisplatin-induced cachexia model. Liver Fcgrt expression correlated with altered baseline catabolic clearance, though elevated clearance was still observed with antibodies having no (human IgA) or reduced (human H310Q IgG1) FcRn binding. We conclude cachexia phenotype coincides with altered antibody clearance, though tumor presence is neither sufficient nor necessary for altered clearance in immunocompetent mice. Magnitude and direction of clearance alteration correlated with hepatic Fcgrt, suggesting changes in FcRn expression and/or recycling function may be partially responsible, though factors beyond FcRn also contribute to altered clearance in cachexia. - Source: PubMed
Publication date: 2023/12/23
Vu Trang TKim KyeongminManna MillenniumThomas JustinRemaily Bryan CMontgomery Emma JCosta TravisGranchie LaurenXie ZhiliangGuo YizhenChen MinCastillo Alyssa Marie MKulp Samuel KMo XiaokuiNimmagadda SridharGregorevic PaulOwen Dwight HGanesan Latha PMace Thomas ACoss Christopher CPhelps Mitch A - Endometrial cancer (EC) has robust molecular diagnostic evidence that correlates well with prognosis. In various types of cancers, FcRn has been identified as an early marker for prognosis. This study aims to assess FcRn expression and its association with clinicopathological features in endometrial cancer. - Source: PubMed
Publication date: 2023/12/14
Song Dae HyunYang JuseokKim Cho HeeKim Min HyeJo Jae YoonBaek Jong Chul - The profitability of the beef cattle production system relies heavily on reproductive traits. Unfortunately, certain traits, such as age at first calving (AFC), calving interval (CI), and gestation length (GL), can pose challenges in traditional breeding programs because of their low heritability (0.01-0.12) and sex-limited characteristics. Another important aspect is the conservation of the genetic resources of animals adapted to the Colombian regions, which implies the preservation and rational use of the creole breeds in the country market. Therefore, this study aimed to identify genomic regions in the creole cattle breed Blanco Orejinegro (BON) that influence the reproductive traits in females. The dataset comprised 439 animals and 118,116 single-nucleotide polymorphisms' (SNPs) markers. The GS3 program was used to identify the SNP effects employing the BAYES Cπ methodology. The number of SNPs with effect for AFC was 25, 1527 for CI, and 23 for GL. Some of the genes found associated with reproductive and growth traits as well as immune response and environmental adaptation ECE1, EPH, EPHB2, SMARCAL1, IGFBP5, IGFBP2, FCGRT, EGFR, MUL1, PINK1, STPG1, CNGB1, TGFB1, OXTR, IL22RA1, MYOM3, OXTR, CNR2, HIVEP3, CTPS1, CXCL8, FCGRT, MREG, TMEM169, PECR, and MC1R. Our results evidenced a high contribution of the genetic architecture of the Colombian creole cattle breed Blanco Orejinegro that may impact should be included in implementing genetic improvement and conservation programs. - Source: PubMed
Publication date: 2023/12/04
Rios Ana Cristina HerreraNasner Sindy Liliana CaivioLondoño-Gil MarisolGonzalez-Herrera Luis GabrielLopez-Herrera AlbeiroFlórez Juan Carlos Rincón - Human serum albumin (HSA) has a long circulatory half-life owing, in part, to interaction with the neonatal Fc receptor (FcRn or FCGRT) in acidic endosomes and recycling of internalised albumin. Vascular endothelial and innate immune cells are considered the most relevant cells for FcRn-mediated albumin homeostasis in vivo. However, little is known about endocytic trafficking of FcRn-albumin complexes in primary human endothelial cells. To investigate FcRn-albumin trafficking in physiologically relevant endothelial cells, we generated primary human vascular endothelial cell lines from blood endothelial precursors, known as blood outgrowth endothelial cells (BOECs). We mapped the endosomal system in BOECs and showed that BOECs efficiently internalise fluorescently labelled HSA predominantly by fluid-phase macropinocytosis. Pulse-chase studies revealed that intracellular HSA molecules co-localised with FcRn in acidic endosomal structures and that the wildtype HSA, but not the non-FcRn-binding HSAH464Q mutant, was excluded from late endosomes and/or lysosomes. Live imaging revealed that HSA is partitioned into FcRn-positive tubules derived from maturing macropinosomes, which are then transported towards the plasma membrane. These findings identify the FcRn-albumin trafficking pathway in primary vascular endothelial cells, relevant to albumin homeostasis. - Source: PubMed
Publication date: 2023/08/11
Pannek AndreasBecker-Gotot JanineDower Steven KVerhagen Anne MGleeson Paul A