Human IgG (gamma)
- Known as:
- Human Immunoglobulin G (g)
- Catalog number:
- SILGA/05
- Product Quantity:
- 0.5 ml.
- Category:
- -
- Supplier:
- Accu
- Gene target:
- Human IgG (gamma)
Related genes to: Human IgG (gamma)
- Gene:
- AGPAT3 NIH gene
- Name:
- 1-acylglycerol-3-phosphate O-acyltransferase 3
- Previous symbol:
- -
- Synonyms:
- LPAAT-gamma, LPAAT3
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-16
- Date modifiied:
- 2019-03-26
- Gene:
- AKT3 NIH gene
- Name:
- AKT serine/threonine kinase 3
- Previous symbol:
- -
- Synonyms:
- PKBG, RAC-gamma, PRKBG
- Chromosome:
- 1q43-q44
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-16
- Date modifiied:
- 2018-02-13
- Gene:
- AP1AR NIH gene
- Name:
- adaptor related protein complex 1 associated regulatory protein
- Previous symbol:
- C4orf16
- Synonyms:
- PRO0971, 2C18, gamma-BAR
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-15
- Date modifiied:
- 2015-12-17
- Gene:
- BBOX1 NIH gene
- Name:
- gamma-butyrobetaine hydroxylase 1
- Previous symbol:
- BBOX
- Synonyms:
- gamma-BBH, G-BBH, BBH
- Chromosome:
- 11p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-26
- Date modifiied:
- 2016-10-05
- Gene:
- CBX3 NIH gene
- Name:
- chromobox 3
- Previous symbol:
- -
- Synonyms:
- HP1Hs-gamma
- Chromosome:
- 7p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-12
- Date modifiied:
- 2015-11-24
Related products to: Human IgG (gamma)
Related articles to: Human IgG (gamma)
- Tuft cells are a type of rare epithelial cells that have been recently found to utilize taste signal transduction pathways to detect and respond to various noxious stimuli and pathogens, including allergens, bacteria, protists and parasitic helminths. It is, however, not fully understood how many different types of pathogens they can sense or what exact molecular mechanisms they employ to initiate targeted responses. In this study, we found that an anaerobic pathobiont microbe, (), can induce tuft cell proliferation in the proximal colon whereas the microbe's lysate can stimulate these proximal colonic tuft cells to release interleukin-25 (IL-25). Nullification of the and genes that encode the G protein subunit Gγ13 and transient receptor potential ion channel Trpm5, respectively, or application of the Tas2r inhibitor allyl isothiocyanate (AITC), G protein Gβγ subunit inhibitor Gallein or the phospholipase Cβ2 (PLCβ2) inhibitor U73122 reduces -elicited tuft cell proliferation or IL-25 release or both. Furthermore, conditional knockout or knockout diminishes the expression of gasdermins C2, C3 and C4, and concomitantly increases the activated forms of caspases 3, 8 and 9 as well as the number of TUNEL-positive apoptotic cells in the proximal colon. Together, our data suggest that taste signal transduction pathways are not only involved in the detection of infection, but also contribute to helping maintain gasdermin expression and prevent apoptotic cell death in the proximal colon, and these findings provide another strategy to combat infection and sheds light on new roles of taste signaling proteins along with gasdermins in protecting the integrity of the proximal colonic epithelium. - Source: PubMed
Publication date: 2023/10/25
Lei HaoYu DefuXue Yan-BoLi Yi-HongGong Shi-MengPeng Yuan-YuanLiu Kai-FangBuratto DamianoYang YisenZhang Sai-SaiWu MinZhou RuhongHuang Liquan - Temporal transcription profiles of fetal testes with Sertoli cell ablation were examined in 4-day culture using a diphtheria toxin (DT)-dependent cell knockout system in AMH-TRECK transgenic (Tg) mice. RNA analysis revealed that ovarian-specific genes, including Foxl2, were ectopically expressed in DT-treated Tg testis explants initiated at embryonic days 12.5-13.5. FOXL2-positive cells were ectopically observed in two testicular regions: near the testicular surface epithelia and around its adjacent mesonephros. The surface FOXL2-positive cells, together with ectopic expression of Lgr5 and Gng13 (markers of ovarian cords), were derived from the testis epithelia/subepithelia, whereas another FOXL2-positive population was the 3βHSD-negative stroma near the mesonephros. In addition to high expression of Fgfr1/Fgfr2 and heparan sulfate proteoglycan (a reservoir for FGF ligand) in these two sites, exogenous FGF9 additives repressed DT-dependent Foxl2 upregulation in Tg testes. These findings imply retention of Foxl2 inducibility in the surface epithelia and peri-mesonephric stroma of the testicular parenchyma, in which certain paracrine signals, including FGF9 derived from fetal Sertoli cells, repress feminization in these two sites of the early fetal testis. - Source: PubMed
Publication date: 2023/07/17
Imaimatsu KenyaHiramatsu RyujiTomita AyakoItabashi HirotsuguKanai Yoshiakira - Osteoporosis (OP) is one of the major public health problems in the world. However, the biomarkers between the peripheral blood mononuclear cells (PBMs) and bone tissue for prognosis of OP have not been well characterized. This study aimed to explore the similarities and differences of the gene expression profiles between the PBMs and bone tissue and identify potential genes, transcription factors (TFs) and hub proteins involved in OP. The patients were enrolled as an experimental group, and healthy subjects served as normal controls. Human whole-genome expression chips were used to analyze gene expression profiles from PBMs and bone tissue. And the differentially expressed genes (DEGs) were subsequently studied using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. The above DEGs were constructed into protein-protein interaction network. Finally, TF-DEGs regulation networks were constructed. Microarray analysis revealed that 226 DEGs were identified between OP and normal controls in the PBMs, while 2295 DEGs were identified in the bone tissue. And 13 common DEGs were obtained by comparing the 2 tissues. The Gene Ontology analysis indicated that DEGs in the PBMs were more involved in immune response, while DEGs in bone were more involved in renal response and urea transmembrane transport. And the Kyoto Encyclopedia of Genes and Genomes analysis indicated almost all of the pathways in the PBMs were overlapped with those in the bone tissue. Furthermore, protein-protein interaction network presented 6 hub proteins: PI3K1, APP, GNB5, FPR2, GNG13, and PLCG1. APP has been found to be associated with OP. Finally, 5 key TFs were identified by TF-DEGs regulation networks analysis (CREB1, RUNX1, STAT3, CREBBP, and GLI1) and were supposed to be associated with OP. This study enhanced our understanding of the pathogenesis of OP. PI3K1, GNB5, FPR2, GNG13, and PLCG1 might be the potential targets of OP. - Source: PubMed
Xie LihuaFeng EryouLi ShengqiangChai HaoChen JuanLi LiGe Jirong - Technical advances have led to an explosion in the amount of biological data available in recent years, especially in the field of RNA sequencing. Specifically, spatial transcriptomics (ST) datasets, which allow each RNA molecule to be mapped to the 2D location it originated from within a tissue, have become readily available. Due to computational challenges, ST data has rarely been used to study RNA processing such as splicing or differential UTR usage. We apply the ReadZS and the SpliZ, methods developed to analyze RNA process in scRNA-seq data, to analyze spatial localization of RNA processing directly from ST data for the first time. Using Moran's I metric for spatial autocorrelation, we identify genes with spatially regulated RNA processing in the mouse brain and kidney, re-discovering known spatial regulation in and identifying previously-unknown spatial regulation in genes such as , , , , , , , and . The rich set of discoveries made here from commonly used reference datasets provides a small taste of what can be learned by applying this technique more broadly to the large quantity of Visium data currently being created. - Source: PubMed
Publication date: 2023/03/14
Olivieri JuliaSalzman Julia - The traditional Chinese medicines of Buyang Huanwu decoction (BYHW), Naoxintong capsule (NXT), and Yangyin Tongnao granules (YYTN) have excellent effects in preventing and treating cerebrovascular disease and are widely tolerated by patients. However, their effects on middle cerebral artery occlusion (MCAO) remain unknown. - Source: PubMed
Publication date: 2022/09/21
Yin JunjunYang JiehongZhao BuchangZhao ChaoFu WeiHe YuZeng MiaolinYang YutingWei XiaoyuDing ZhishanBai JingxianWan HaitongZhou Huifen