HOXD4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
- Known as:
- HOXD4 belongs homeobox family genes. homeobox genes encode a very conserved family transcription factors play important role morphogenesis multicellular organisms.
- Catalog number:
- 27-331
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- HOXD4 belongs the homeobox family genes. The genes encode highly conserved transcription factors that play important role morphogenesis all multicellular organisms.
Related genes to: HOXD4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
- Gene:
- HOXD4 NIH gene
- Name:
- homeobox D4
- Previous symbol:
- HOX4B, HOX4
- Synonyms:
- -
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-15
- Date modifiied:
- 2015-09-07
Related products to: HOXD4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
(-)-Indolactam V-combined with growth factors, can direct the differentiation of hESCs to Pdx1-expressing pancreatic progenitors(-)-Indolactam V-combined with growth factors, can direct the differentiation of hESCs to Pdx1-expressing pancreatic progenitors(all-cis)-7,10,13,16,19-Docosapentaenoic Acid C22H34O2 CAS: 24880-45-3(all-cis)-7,10,13,16,19-Docosapentaenoic Acid CAS: 24880-45-3 Formula: C22H34O2 (all-cis)-7,10,13,16,19-Docosapentaenoic Acid N-Hydroxysuccinimidyl Ester CAS: Formula: C26H37NO4(all-cis)-7,10,13,16,19-Docosapentaenoic-d5 Acid CAS: Formula: C22H29D5O2(all-cis)-8,11,14,17-Eicosatetraenoic Acid C20H32O2 CAS: 24880-40-8
(all-cis)-8,11,14,17-Eicosatetraenoic Acid CAS: 24880-40-8
Formula: C20H32O2 (all-cis)-8,11,14,17-Eicosatetraenoic Acid N-Hydroxysuccinimidyl Ester CAS: Formula: C24H35NO4(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester CAS: 188404-10-6 Formula: C21H36FO2P(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid
C21H32O2 CAS: 24257-10-1(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid
CAS: 24257-10-1 Formula: C21H32O2 (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester C23H36O2 CAS: 131775-86-5(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester CAS: 131775-86-5 Formula: C23H36O2 (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid N-Succinimide
CAS: Formula: C25H35NO4 Related articles to: HOXD4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
- HOXD1, HOXD3, and HOXD4 are members of the HOXD genes family and are related to tumorigenesis of the tumor. However, whether HOXDs (1, 3, 4) have a crucial role across pan-cancer is still unknown. HOXD1, HOXD3, and HOXD4 expressions were analyzed using public databases in 33 types of tumors. The UCSC Xena website was carried out to investigate the relationship between the expression of genes and the progress of cancers. The biological functions of HOXD3 were tested by colony forming, transwell, wound healing, and xenograft assay and . GSEA was used to identify the associated cancer hallmarks with HOXDs expression. Immune cell infiltration analysis was applied to verify the immune cell infiltrations related to genes. The results showed HOXD1, HOXD3, and HOXD4 co-low expressed in BRCA, COAD, KICH, KIRC, KIRP, READ, and TGCT. In the KIRC, all of HOXDs expression was connected with tumor stage and histological grade. Upregulation of HOXDs was associated with improved OS, DSS, and PFI. Down-expression of HOXD3 induced cell proliferation, migration, and invasion and . In addition, HOXDs were connected with immune-activated hallmarks and cancer immune cell infiltrations. These findings demonstrated that HOXDs may be indicative biomarkers for the prognosis and immunotherapy in pan-cancer. - Source: PubMed
Publication date: 2023/10/12
Wang LuminWang XiaofeiSun HaifengWang WenjingCao Li - Osteocytes sense mechanical loads and transduce mechanical signals into a chemical response. They are the most abundant bone cells deeply embedded in mineralized bone matrix, which affects their regulatory activity in the mechanical adaptation of bone. The specific location in the calcified bone matrix hinders studies on osteocytes in the in vivo setting. Recently, we developed a three-dimensional mechanical loading model of human osteocytes in their native matrix, allowing to study osteocyte mechanoresponsive target gene expression in vitro. Here we aimed to identify differentially expressed genes by mapping the response of human primary osteocytes in their native matrix to mechanical loading using RNA sequencing. Human fibular bone was retrieved from 10 donors (age: 32-82 years, 5 female, 5 male). Cortical bone explants (8.0 × 3.0 × 1.5 mm; length × width × height) were either not loaded or mechanically loaded by 2000 or 8000 μɛ for 5 minutes, followed by 0, 6, or 24 hours post-culture without loading. High-quality RNA was isolated, and differential gene expression analysis performed by R2 platform. Real-time PCR was used to confirm differentially expressed genes. Twenty-eight genes were differentially expressed between unloaded and loaded (2000 or 8000 μɛ) bone at 6 hours post-culture, and 19 genes at 24 hours post-culture. Eleven of these genes were related to bone metabolism, ie, , , , , , , and at 6 hours post-culture, and , , , and at 24 hours post-culture. Mechanical loading significantly decreased gene expression, which was confirmed by real-time PCR. In conclusion, mechanically loaded osteocytes differentially expressed 47 genes, of which 11 genes were related to bone metabolism. RNF213 might play a role in mechanical adaptation of bone by regulating angiogenesis, which is a prerequisite for successful bone formation. The functional aspects of the differentially expressed genes in bone mechanical adaptation requires future investigation. © 2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. - Source: PubMed
Publication date: 2023/02/21
Zhang Chenvan Essen Huib WSie DaoudMicha DimitraPals GerardKlein-Nulend JennekeBravenboer Nathalie - Intestinal organoids and enteroids as excellent models are miniaturized and simplified for studying intestinal physiological and pathological functions, drug screening, and regenerative medicine. Recently, the application demands for organoids and enteroids in organ development and nutrition metabolism, immune and cancer research increased. But there are few comparative studies on both of them, especially in immunity and metabolism, which is also conducive to further clarifying the role of crypt stem cells and stromal cells. In our study, "natural" organoids were obtained by tissue culture from fetal bovine jejunum and enteroids were successfully isolated and cultured from organoids without supplementing exogenous factors and Matrigel. These mini-guts displayed similar features to the intestine through immunohistochemistry and transmission electron microscopy. Organoid and enteroid were systematically compared based on the transcriptome. And some of the results were verified by qRT-PCR. Our results showed KDGs (Key driver genes) (e.g., SLC13A1, HOXA7, HOXA6, HOXA5, and HOXD4) of organoids enriched in signaling pathways related to organ development and morphology and metabolism. KDGs (e.g., IL-6, PTGS2, CDH1, JUN, and EGFR) of enteroid were involved in cancer, MAPK, and immune-related signaling pathways. To the Wnt signaling pathway, highly expressed genes in organoids, including RSPO2, NOTUM, WNT6, and RSPO3, supported the homeostasis of crypt stem cells. Enteroids highly expressed CTNNB1 and WNTs. In addition, we found that organoids and enteroids carried out different functions in immunity and metabolism due to different cell compositions. Therefore, it suggested organoid is more compatible and comprehensive, and enteroid is qualified for the research of immunity and cancer. - Source: PubMed
Publication date: 2022/09/20
Zhang JuntaoLi JuanjuanYan PenghuiHe LaizengZhang XuemeiWang XiaolongShi YakeDeng LixinZhang ZhiPingZhao Baoyu - miR-10b is silenced in normal neuroglial cells of the brain but commonly activated in glioma, where it assumes an essential tumor-promoting role. We demonstrate that the entire miR-10b-hosting HOXD locus is activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping. This mechanism requires two interacting lncRNAs, HOXD-AS2 and LINC01116, one associated with HOXD3/HOXD4/miR-10b promoter and another with the remote enhancer. Knockdown of either lncRNA in glioma cells alters CTCF and cohesin binding, abolishes chromatin looping, inhibits the expression of all genes within HOXD locus, and leads to glioma cell death. Conversely, in cortical astrocytes, enhancer activation is sufficient for HOXD/miR-10b locus reorganization, gene derepression, and neoplastic cell transformation. LINC01116 RNA is essential for this process. Our results demonstrate the interplay of two lncRNAs in the chromatin folding and concordant regulation of miR-10b and multiple HOXD genes normally silenced in astrocytes and triggering the neoplastic glial transformation. - Source: PubMed
Publication date: 2022/04/06
Deforzh EvgenyUhlmann Erik JDas EashitaGalitsyna AleksandraArora RamilSaravanan HariniRabinovsky RosaliaWirawan Aditya DTeplyuk Nadiya MEl Fatimy RachidPerumalla SucikaJairam AnirudhWei ZhiyunMirny LeonidKrichevsky Anna M - Ovarian cancer is the most common gynecological malignancy, ranking as the fifth leading cause of cancer-related deaths among females in the United States. Homeobox D4 (HOXD4) is a transcription factor belonging to the homeobox protein family, which plays a critical role in morphogenesis during embryo development. Here we aimed to study the HOXD4 expression in ovarian serous carcinoma (OSC) and determine its clinical significance. - Source: PubMed
Yu BoGuo Xiaoqing