Homo sapiens,Human,POU domain, class 5, transcription factor 2,POU5F2,Sperm 1 POU domain transcription factor,SPRM1,SPRM-1
- Known as:
- Homo sapiens,Human,POU domain, class 5, transcription factor 2,POU5F2,Sperm 1 POU domain transcription factor,SPRM1,SPRM-1
- Catalog number:
- EIAAB31751
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- Homo sapiens Human POU domain class 5 transcription factor 2 POU5F2 Sperm 1 SPRM1 SPRM-1
Related genes to: Homo sapiens,Human,POU domain, class 5, transcription factor 2,POU5F2,Sperm 1 POU domain transcription factor,SPRM1,SPRM-1
- Gene:
- POU5F2 NIH gene
- Name:
- POU domain class 5, transcription factor 2
- Previous symbol:
- -
- Synonyms:
- SPRM-1, FLJ25680
- Chromosome:
- 5q15
- Locus Type:
- gene with protein product
- Date approved:
- 2007-07-13
- Date modifiied:
- 2016-10-25
Related products to: Homo sapiens,Human,POU domain, class 5, transcription factor 2,POU5F2,Sperm 1 POU domain transcription factor,SPRM1,SPRM-1
Related articles to: Homo sapiens,Human,POU domain, class 5, transcription factor 2,POU5F2,Sperm 1 POU domain transcription factor,SPRM1,SPRM-1
- Di(2-ethylhexyl)phthalate (DEHP) is a typical endocrine-disrupting chemical and reproductive toxicant. Although previous studies have attempted to describe the mechanism by which DEHP exposure results in reproductive dysfunction, few studies focused on puberty, a critical period of reproductive development, and the increased susceptibility to injury in adolescents. To elucidate the mechanism underpinning the testicular effects of DEHP in puberty, we sought to investigate the JAZF1/TR4 pathway in the testes of pubertal rats. Specifically, we focused on the role of the JAZF1/TR4 pathway in male reproduction, including the genes JAZF1, TR4, Sperm 1, and Cyclin A1. In the present study, rats were exposed to increasing concentrations of DEHP (0, 250, 500, and 1000 mg/kg/day) by oral gavages for 30 days. Then we assayed testicular zinc and oxidative stress levels. Our results indicated that DEHP exposure could lead to oxidative stress and decrease the contents of testicular zinc. Additionally, significant morphological changes and cell apoptosis were observed in testes exposed to DEHP, as identified by hematoxylin and eosin staining and the terminal deoxynucleotidyl transferase-mediated nick and labeling assay. By measuring the expression levels of the above relevant genes by qPCR, we found the DEHP-induced increased expression of JAZF1 and decreased expression of TR4, Sperm 1, and Cyclin A1. Therefore, we have demonstrated that in vivo exposure to DEHP might induce reproductive toxicity in pubertal male rats through the JAZF1/TR4 pathway and oxidative stress. - Source: PubMed
Publication date: 2019/02/12
Shi Yu-QinFu Guo-QingZhao JingCheng Shen-ZhouLi YouYi Ling-NaLi ZhenZhang LingZhang Zhi-BingDai JuanZhang Da-Yi - To establish the method of 2-dimensional electrophoresis(2-DE) for proteins of human spermatozoa and to construct a protein map of human spermatozoa. - Source: PubMed
Luo KFan L QLu G X - Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell. - Source: PubMed
Pearse R VDrolet D WKalla K AHooshmand FBermingham J RRosenfeld M G - Spermatogenesis is an orderly process whereby male germ cells pass through sequential phases of differentiation to develop into mature spermatozoa. At present, little is known about the factors that regulate this process. The POU domain represents a group of transcription-activator proteins with well-described roles in development. These proteins have been shown to regulate the tissue-specific expression of genes involved in cellular differentiation. The recent identification of Sperm-1, a testis-specific POU-domain protein expressed in primary spermatocytes just prior to the onset of meiosis, suggests that this protein may be involved in the regulation of male germ-cell differentiation. Continued evaluation of Sperm-1 and other related transcriptional activators may shed some light on the regulation of spermatogenesis. - Source: PubMed
Zini AMielnik ASchlegel P N - Members of the POU-domain gene family encode for transcriptional regulatory molecules that are important for terminal differentiation of several organ systems, including anterior pituitary, sensory neurons, and B lymphocytes. We have identified a POU-domain factor, referred to as sperm 1 (Sprm-1). This factor is most related to the transactivator Oct-3/4, which is expressed in the early embryo, primordial germ cells, and the egg. However, in contrast with Oct-3/4, rat Sprm-1 is selectively expressed during a 36- to 48-hr period immediately preceding meiosis I in male germ cells. Although the POU-domain of Sprm-1 is divergent from the POU-domains of Oct-1 and Oct-2, random-site-selection assay reveals that Sprm-1 preferentially binds to a specific variant of the classic octamer DNA-response element in which the optimal sequence differs from that preferred by Oct-1 and Pit-1. These data suggest that the Sprm-1 gene encodes a DNA-binding protein that may exert a regulatory function in meiotic events that are required for terminal differentiation of the male germ cell. - Source: PubMed
Andersen BPearse R VSchlegel P NCichon ZSchonemann M DBardin C WRosenfeld M G