h. MMP-2 -ELISA kit
- Known as:
- h. MMP-2 -Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- EK0459
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- SDlabs
- Gene target:
- . MMP-2 -ELISA kit
Related genes to: h. MMP-2 -ELISA kit
- Gene:
- IMMP2L NIH gene
- Name:
- inner mitochondrial membrane peptidase subunit 2
- Previous symbol:
- IMMP2L-IT1
- Synonyms:
- IMP2
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-11
- Date modifiied:
- 2018-01-23
- Gene:
- MMP2 NIH gene
- Name:
- matrix metallopeptidase 2
- Previous symbol:
- CLG4, CLG4A
- Synonyms:
- TBE-1
- Chromosome:
- 16q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2015-02-23
- Gene:
- MMP15 NIH gene
- Name:
- matrix metallopeptidase 15
- Previous symbol:
- -
- Synonyms:
- MT2-MMP, MTMMP2, SMCP-2
- Chromosome:
- 16q21
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-13
- Date modifiied:
- 2016-10-05
- Gene:
- MMP23A NIH gene
- Name:
- matrix metallopeptidase 23A (pseudogene)
- Previous symbol:
- MMP21
- Synonyms:
- MIFR
- Chromosome:
- 1p36.33
- Locus Type:
- pseudogene
- Date approved:
- 1999-08-26
- Date modifiied:
- 2016-10-05
- Gene:
- MMP23B NIH gene
- Name:
- matrix metallopeptidase 23B
- Previous symbol:
- MMP22
- Synonyms:
- MIFR, MIFR-1
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-26
- Date modifiied:
- 2016-10-05
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- During the reproductive cycle of (), their gonads undergo degeneration and re-maturation including the degradation of proteins in the extracellular matrix (ECM). Matrix metalloproteinases (MMPs), a family of zinc proteases, play a crucial role in ECM degradation. - Source: PubMed
Publication date: 2024/04/15
Zheng RenchiShi HongjuanRu XiaoyingJiang DongnengHuang YangZhu ChunhuaLi Guangli - Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with high heterogeneity, poor prognosis, and a low 10-year survival rate of less than 50%. Although cellular senescence displays extensive effects on cancer, the comprehensions of cellular senescence-related characteristics in TNBC patients remains obscure. - Source: PubMed
Publication date: 2024/02/29
Cao TengfeiHuang MengjieHuang XinyueTang Tian - Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expression in peripheral blood and eicosanoids in urine, in a Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), TB only(n = 28), DM(HbA1c ≥ 6.5%) only(n = 11), and a control group of close TB contacts who did not have TB or DM(n = 13). After cross-validation, baseline expression or abundance of MMP-28, LTE-4, 11-dTxB2, PGDM, FBXO6, SECTM1, and LINCO2009 differentiated the four patient groups. A distinct multi-omic-derived, dimensionally reduced, signature was associated with TB, regardless of glycemic status. SECTM1 and FBXO6 mRNA levels were positively correlated with sputum acid-fast bacilli grade in TB-DM. Values of the biomarkers decreased during the course of anti-TB therapy. Our study identified several markers associated with the pathophysiology of TB-DM that could be evaluated in future mechanistic investigations. - Source: PubMed
Publication date: 2024/02/05
Vinhaes Caian LFukutani Eduardo RSantana Gabriel CArriaga María BBarreto-Duarte BeatrizAraújo-Pereira MarianaMaggitti-Bezerril MateusAndrade Alice M SFigueiredo Marina CMilne Ginger LRolla Valeria CKristki Afrânio LCordeiro-Santos MarceloSterling Timothy RAndrade Bruno BQueiroz Artur T L - To determine whether various inflammatory-, angiogenic/anti-angiogenic-, and extracellular matrix remodeling-associated proteins in plasma, alone or in combination with conventional blood-based markers, can predict intra-amniotic inflammation and/or microbial invasion of the amniotic cavity (IAI/MIAC) in women with spontaneous preterm labor (PTL). - Source: PubMed
Publication date: 2024/02/08
Joo EunwookHong SubeenPark Kyo HoonKim Hyeon JiLee Min JungShin Sue - Matrix metalloproteinases (MMPs) play an essential role in various physiological events. Recent studies have revealed its carcinogenic effect in malignancies. However, the different expression patterns, prognostic value, and immunological value of MMPs in pancreatic ductal adenocarcinoma (PDAC) are yet to be comprehensively explored. We utilized Gene Expression Profiling Interactive Analysis (GEPIA) and Gene Expression Omnibus databases to explore the abnormal expression of MMPs in PDAC. Then, Kaplan-Meier survival curve and Cox regression analysis were performed to assess the prognostic value of MMPs. Association between MMPs expression and clinicopathological features was analyzed through UALCAN website. Functional annotations and GSEA analysis were performed to excavate the possible signaling pathways involving prognostic-related MMP. TIMER and TISCH database were used to performed immune infiltration analysis. The expression of prognostic-related MMP in pancreatic cancer cell lines and normal pancreatic cells was detected by Real time quantitative PCR. We observed that 10 MMP genes were consistently up-regulated in GEPIA and GSE62452 dataset. Among them, five highly expressed MMPs (MMP1, MMP3, MMP11, MMP14, MMP28) were closely related to poor clinical outcomes of PDAC patients. Cox regression analysis indicated MMP28 was a risk factor influencing the overall survival of patients. In the clinicopathological analysis, up-regulated MMP28 was significantly associated with higher tumor grade and the mutation status of TP53. GSEA analysis demonstrated that high expression of MMP28 was involved in "interferon_alpha_response" and "P53_pathway". Immune infiltration analysis showed that there was no correlation between MMP28 expression and immune cell infiltration. Single-cell sequencing analysis showed MMP28 has strong correlations with malignant cells and stromal cells infiltration in the tumor microenvironment. And MMP28 was highly expressed in various pancreatic cancer cell lines. In conclusion, MMP28 may represent a potential prognosis biomarker and novel therapeutic molecular targets for PDAC. - Source: PubMed
Publication date: 2023/10/11
Luan HongJian LingeHuang YuyanGuo YutongZhou Liping