GeBAflex tube Electrophoresis, ElectroElution, Extraction & Dialysis Kit, *Maxi (3 ml max vol.), includes tubes, 3.5 kD cut_off, buffers, supporting tray, floating rack, handbook, for DNA_Oligo, RNA,
- Known as:
- GeBAflex tube Electrophoresis, ElectroElution, Extraction & Dialysis Kit, *Maxi (3 milliliter max vol.), includes tubes, 3.5 kD cut_off, buffers, supporting tray, floating rack, handbook, DNA_Oligo, RNA,
- Catalog number:
- GEBAT030
- Product Quantity:
- kit
- Category:
- -
- Supplier:
- Accu
- Gene target:
- GeBAflex tube Electrophoresis ElectroElution Extraction & Dialysis Kit *Maxi (3 max vol.) includes tubes 3.5 cut_off buffers supporting tray floating rack handbook for DNA_Oligo RNA
Related genes to: GeBAflex tube Electrophoresis, ElectroElution, Extraction & Dialysis Kit, *Maxi (3 ml max vol.), includes tubes, 3.5 kD cut_off, buffers, supporting tray, floating rack, handbook, for DNA_Oligo, RNA,
- Gene:
- TSC2 NIH gene
- Name:
- TSC complex subunit 2
- Previous symbol:
- TSC4
- Synonyms:
- tuberin, LAM, PPP1R160
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: GeBAflex tube Electrophoresis, ElectroElution, Extraction & Dialysis Kit, *Maxi (3 ml max vol.), includes tubes, 3.5 kD cut_off, buffers, supporting tray, floating rack, handbook, for DNA_Oligo, RNA,
Related articles to: GeBAflex tube Electrophoresis, ElectroElution, Extraction & Dialysis Kit, *Maxi (3 ml max vol.), includes tubes, 3.5 kD cut_off, buffers, supporting tray, floating rack, handbook, for DNA_Oligo, RNA,
- - Source: PubMed
Publication date: 2024/04/28
Fu JiahuiLiang PeiliZheng YingchunXu CailingXiong FuYang Fang - We recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 36 healthy recreationally active young males (age: 24.2±4.1 y) ingested either: 1) 0.36 g ∙ kg bodyweight of the ketone monoester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (KET), 2) 10 g whey protein (PRO), or 3) the combination of both (KET+PRO). Muscle biopsies were obtained in the overnight postabsorptive state (basal conditions), and at 120- and 300-minutes in the postprandial period for immunofluorescence assessment of protein translocation and co-localization of mTOR-related signaling molecules. All treatments resulted in a significant (Interaction: <0.0001) decrease in tuberous sclerosis complex 2 (TSC2)-Ras homolog enriched in brain (Rheb) co-localization at 120-minutes vs. basal; however, the decrease was sustained at 300-minutes vs. basal (<0.0001) only in KET+PRO. PRO and KET+PRO increased (Interaction: <0.0001) mTOR-Rheb co-localization at 120-minutes vs. basal; however, KET+PRO resulted in a sustained increase in mTOR-Rheb co-localization at 300-minutes that was greater than KET and PRO. Treatment intake increased mTOR-wheat germ agglutinin (WGA) co-localization at 120- and 300-minutes (Time: =0.0031), suggesting translocation toward the fiber periphery. These findings demonstrate that ketone monoester intake can influence the spatial mechanisms involved in the regulation of mTORC1 in human skeletal muscle. - Source: PubMed
Publication date: 2024/04/29
Hannaian Sarkis JLov JamieCheng-Boivin ZacharieAbou Sawan SidneyHodson NathanGentil Benoit JMorais José AChurchward-Venne Tyler A - Rare sarcomas present significant treatment challenges compared to more prevalent soft tissue sarcomas due to limited treatment options and a poor understanding of their biology. This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models-including patient-derived xenograft (PDX), 3D, and monolayer primary cultures-we successfully replicated crucial molecular traits observed in the patient's tumor, such as smooth muscle actin and CD99 expression, along with specific mutations in genes like and . These models are helpful in assessing the potential for an in-depth exploration of this tumor's biology. This comprehensive approach holds promise in identifying potential therapeutic avenues for managing this exceedingly rare soft tissue sarcoma. - Source: PubMed
Publication date: 2024/03/28
Sousa Ariane Cavalcante Dos SantosFernandes Bruno Leonardo Nascimento Correada Silva Jeronimo Paulo AssisStevanato Filho Paulo RobertoCoimbra Luiza Bitencourt de Carvalho Tercide Oliveira Beserra AdrianoAlvarenga Ana LuizaMaida GiovannaGuimaraes Camila TokumotoNakamuta Ingrid MartinezMarchi Fabio AlbuquerqueAlves CamilaLichtenfels Martinade Farias Caroline BrunettoKupper Bruna Elisa CatinCosta Felipe D'Almeidade Mello Celso Abdon LopesCarraro Dirce MariaTorrezan Giovana TardinLopes AdemarDos Santos Tiago Goss - The thyroid gland is susceptible to abnormal epithelial cell growth, often resulting in thyroid dysfunction. The serine-threonine protein kinase mechanistic target of rapamycin (mTOR) regulates cellular metabolism, proliferation, and growth through two different protein complexes, mTORC1 and mTORC2. The PI3K-Akt-mTORC1 pathway's overactivity is well associated with heightened aggressiveness in thyroid cancer, but recent studies indicate the involvement of mTORC2 as well. - Source: PubMed
Publication date: 2024/04/25
Ludke Rossetti CamilaAlves Bruna LourenconiMartins Pecanha Flavia LeticiaFranco AimeNosé VaniaCarneiro Everardo MagalhãesLew John IBernal-Mizrachi ErnestoWerneck de Castro Joao Pedro - Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous syndrome with variable phenotypes. Recent updates of TSC diagnostic criteria reaffirmed the defined genetic diagnostic criterion as the finding of a pathogenic DNA alteration in either TSC1 or TSC2 genes. It also slightly modified definite clinical diagnostic criteria. TSC-associated skin lesions in infancy are important clinical signs to select individuals with possible TSC for a closer clinical follow-up and genetic testing. - Source: PubMed
Publication date: 2024/04/23
Nunes Beatriz AzevedoRomano Ana Karolina Ferreira GonçalvesPasa Morgan Mariana AparecidaGonçalves Alice AndradeCardozo Laís Faria Masulkde Almeida Luiz Gustavo DufnerHaddad Luciana AmaralCrippa Ana Chrystina de SouzaAntoniuk Sergio AntonioAbagge Kerstin Taniguchi