FITC Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_, 25mg
- Known as:
- fluorecein Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_, 25mg
- Catalog number:
- F-1104-25
- Product Quantity:
- 25mg
- Category:
- -
- Supplier:
- EYlabs
- Gene target:
- FITC Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_ 25mg
Related genes to: FITC Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_, 25mg
- Gene:
- YBX2 NIH gene
- Name:
- Y-box binding protein 2
- Previous symbol:
- -
- Synonyms:
- MSY2, CSDA3, Contrin
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-11
- Date modifiied:
- 2015-11-19
Related products to: FITC Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_, 25mg
Related articles to: FITC Conjugated Canavalia ensiformis Lectin (Jackbean) _Con A_, 25mg
- The Y-box-binding proteins (YBX) act as a multifunctional role in tumor progression, metastasis, drug resistance by regulating the transcription and translation process. Nevertheless, their functions in a pan-cancer setting remain unclear. - Source: PubMed
Publication date: 2024/04/18
Yuan ZeLi BinbinLiao WenminKang DaDeng XinpeiTang HailinXie JindongHu DandanChen Aiqin - Y-box binding protein 2 (YBX2) is an essential modulator of brown adipose tissue activation, yet the regulation on its own expression and the involved mechanism remains largely unknown. Herein, we report the YBX2 protein level, but not mRNA level, is induced in response to acute β-adrenergic signaling. In this context, YBX2 is a dual substrate for both AMPK and Akt2. The phosphorylation at Thr115 by AMPK or at Ser137 by Akt2 facilitates YBX2 accumulation in brown adipocytes by decreasing ubiquitination-mediated degradation. Beyond stabilizing PGC1α mRNA, increased YBX2 upon thermogenic activation assists the expression of glycolytic enzymes, promotes glucose utilization and lactate production. Mechanistically, YBX2 modulates translation of glycolytic genes via direct binding to 5'-UTRs of these genes. Together these findings suggest YBX2 is responsive to thermogenic stimuli by phosphorylation modification, and stabilized YBX2 helps to boost glycolysis and thermogenesis in brown adipocytes. - Source: PubMed
Publication date: 2023/09/28
Zhao QingwenYu ChaoXu XiaoxuanJin WenfangZhang ZheHuang HaiyanGao YuePan Dongning - Mammalian reproductive ability is regulated by many factors, among which the fatty acid metabolism network provides energy for oocyte growth and primordial follicle formation during early mouse oogenesis. But the mechanism behind that is still unknown. Stearoyl-CoA desaturase 1 (Scd1) gene expression is increased during the oogenesis process, supporting the oocyte's healthy growth. Taking advantage of gene-edited mice lacking stearoyl-Coenzyme A desaturase 1 gene (Scd1), we analyzed relative gene expression in perinatal ovaries from wildtype, and Scd1 mice. Scd1 deficiency dysregulates expression of meiosis-related genes (e.g., Sycp1, Sycp2, Sycp3, Rad51, Ddx4) and a variety of genes (e.g., Nobox, Lhx8, Bmp15, Ybx2, Dppa3, Oct4, Sohlh1, Zp3) associated with oocyte growth and differentiation, leading to a lower oocyte maturation rate. The absence of Scd1 significantly impedes meiotic progression, causes DNA damage, and inhibits damage repair in Scd1 ovaries. Moreover, we find that Scd1 absense dramatically disrupts the abundance of fatty acid metabolism genes (e.g., Fasn, Srebp1, Acaca) and the lipid droplet content. Thus, our findings substantiate a major role for Scd1 as a multifunctional regulator of fatty acid networks necessary for oocyte maintenance and differentiation during early follicular genesis. - Source: PubMed
Publication date: 2023/06/12
Niu HuiminAn XuetongWang XinpeiYang MinCheng FeiLei AnminLuo Jun - - Source: PubMed
Publication date: 2023/05/25
Zhang ZhihuaLiu RuyiZhou HongbinLuo YuxiMu JianFu JingWu TianyuChen BiaobangSang QingWang Lei - Among the various seasonal environmental changes, elevated ambient temperature during the summer season is a main cause of stress in dairy and beef cows, leading to impaired reproductive function and fertility. Follicular fluid extracellular vesicles (FF-EVs) play an important role in intrafollicular cellular communication by, in part, mediating the deleterious effects of heat stress (HS). Here we aimed to investigate the changes in FF-EV miRNA cargoes in beef cows in response to seasonal changes: summer (SUM) compared to the winter (WIN) season using high throughput sequencing of FF-EV-coupled miRNAs. In addition to their biological relevance, the potential mechanisms involved in the packaging and release of those miRNAs as a response to environmental HS were elucidated. - Source: PubMed
Publication date: 2023/05/23
Gad AhmedJoyce KamrynMenjivar Nico GrahamHeredia DaniellaRojas Camila SantosTesfaye DawitGonella-Diaza Angela