ETFR-2,ETF-related factor 2,Mouse,Mus musculus,RTEF-1,Tcf13r1,TEA domain family member 4,Tead4,TEAD-4,TEF-1-related factor 1,TEF-1-related factor FR-19,Tef3,Tefr1,Transcriptional enhancer factor TEF-3
- Known as:
- ETFR-2,ETF-related factor 2,Mouse,Mus musculus,RTEF-1,Tcf13r1,TEA domain family member 4,Tead4,TEAD-4,TEF-1-related factor 1,TEF-1-related factor FR-19,Tef3,Tefr1,Transcriptional enhancer factor TEF-3
- Catalog number:
- EIAAB41860
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- ETFR-2 ETF-related factor 2 Mouse Mus musculus RTEF-1 Tcf13r1 TEA domain family member 4 Tead4 TEAD-4 TEF-1-related 1 FR-19 Tef3 Tefr1 Transcriptional enhancer TEF-3
Related genes to: ETFR-2,ETF-related factor 2,Mouse,Mus musculus,RTEF-1,Tcf13r1,TEA domain family member 4,Tead4,TEAD-4,TEF-1-related factor 1,TEF-1-related factor FR-19,Tef3,Tefr1,Transcriptional enhancer factor TEF-3
- Gene:
- TEAD4 NIH gene
- Name:
- TEA domain transcription factor 4
- Previous symbol:
- TCF13L1
- Synonyms:
- TEF-3, TEFR-1, EFTR-2, RTEF-1
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-02
- Date modifiied:
- 2016-01-15
- Gene:
- TRIM37 NIH gene
- Name:
- tripartite motif containing 37
- Previous symbol:
- MUL
- Synonyms:
- KIAA0898, POB1, TEF3
- Chromosome:
- 17q22
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-08
- Date modifiied:
- 2016-01-15
Related products to: ETFR-2,ETF-related factor 2,Mouse,Mus musculus,RTEF-1,Tcf13r1,TEA domain family member 4,Tead4,TEAD-4,TEF-1-related factor 1,TEF-1-related factor FR-19,Tef3,Tefr1,Transcriptional enhancer factor TEF-3
Related articles to: ETFR-2,ETF-related factor 2,Mouse,Mus musculus,RTEF-1,Tcf13r1,TEA domain family member 4,Tead4,TEAD-4,TEF-1-related factor 1,TEF-1-related factor FR-19,Tef3,Tefr1,Transcriptional enhancer factor TEF-3
- This study attempted to investigate how PCSK9 influences the stemness of stomach adenocarcinoma (STAD) cells. - Source: PubMed
Publication date: 2024/04/25
Xu DongshengHan GaohuaZhou XueyiYong HongmeiJia YuanyuanZhao FengjiaoShi Huichang - Psoriasis is an immune-mediated inflammatory skin disorder with a multifaceted pathogenesis. Immune dysregulation and immune cell dysfunction are among the mechanisms involved. TEA domain family member 4 (TEAD4) is suggested to play a role in psoriasis development. TEAD4 expression in keratinocytes may have a chemotactic effect and could disturb the function of FOXP3-positive T lymphocytes. This study aimed to evaluate the expressions of TEAD4 and FOXP3 in lesional, nonlesional psoriatic, and healthy skin and assess the clinical impact of their expression. - Source: PubMed
Publication date: 2024/04/18
Shehata Wafaa AHammam Mostafa AElbakly Amani RElkady Noha - TEAD transcription factors play a central role in the Hippo signaling pathway. In this study, we focused on transcriptional enhancer factor TEF-3 (TEAD4), exploring its regulation by the deubiquitinase OTU domain-containing protein 6A (OTUD6A). We identified OTUD6A as a TEAD4-interacting deubiquitinase, positively influencing TEAD-driven transcription without altering TEAD4 stability. Structural analyses revealed specific interaction domains: the N-terminal domain of OTUD6A and the YAP-binding domain of TEAD4. Functional assays demonstrated the positive impact of OTUD6A on the transcription of YAP-TEAD target genes. Despite no impact on TEAD4 nuclear localization, OTUD6A selectively modulated nuclear interactions, enhancing YAP-TEAD4 complex formation while suppressing VGLL4 (transcription cofactor vestigial-like protein 4)-TEAD4 interaction. Critically, OTUD6A facilitated YAP-TEAD4 complex binding to target gene promoters. Our study unveils the regulatory landscape of OTUD6A on TEAD4, providing insights into diseases regulated by YAP-TEAD complexes. - Source: PubMed
Publication date: 2024/04/09
Kim Hyo JinChoi YunsikLee YuriHwangbo MiKim Jongchan - Transcription factors (TFs) play important roles in early embryonic development, but factors regulating TF action, relationships in signaling cascade, genome-wide localizations, and impacts on cell fate transitions during this process have not been clearly elucidated. In this study, we used uliCUT&RUN-seq to delineate a TFAP2C-centered regulatory network, showing that it involves promoter-enhancer interactions and regulates TEAD4 and KLF5 function to mediate cell polarization. Notably, we found that maternal retinoic acid metabolism regulates TFAP2C expression and function by inducing the active demethylation of SINEs, indicating that the RARG-TFAP2C-TEAD4/KLF5 axis connects the maternal-to-zygotic transition to polarization. Moreover, we found that both genomic imprinting and SNP-transferred genetic information can influence TF positioning to regulate parental gene expressions in a sophisticated manner. In summary, we propose a ternary model of TF regulation in murine embryonic development with TFAP2C as the core element and metabolic, epigenetic, and genetic information as nodes connecting the pathways. - Source: PubMed
Publication date: 2024/04/03
Gao RuiYang GuangWang MengtingXiao JingYi ShanruHuang YanxinGuo ZhenxiangKang YunzheFu QianzhengWang MingzhuXu BenShen ShijunZhu QianshuLiu MengWang LipingCui XinyuYi ShanshanKou XiaochenZhao YanhongGu LiangWang HongGao ShaorongJiang CizhongChen Jiayu - We report here an enzymatic strategy for asparaginyl endopeptidase-mediated peptide cyclization. Incorporation of chloroacetyl groups into the recognition sequence of AEP1 enabled intramolecular cyclization with Cys residues. Combining this strategy and phage display, we identified nanomolar macrocyclic peptide ligands targeting TEAD4. One of the bicyclic peptides binds to TEAD4 with a value of 139 nM, 16 times lower than its linear analogue, demonstrating the utility of this platform in discovering high-affinity macrocyclic peptide ligands. - Source: PubMed
Publication date: 2024/03/26
Wan Xiao-CuiZhang Yan-NiZhang HuaChen YingCui Zhi-HuiZhu Wen-JingFang Ge-Min