EpiQuik HDAC9 Assay Kit (Colorimetric) (96 assays)
- Known as:
- EpiQuik HDAC9 Assay Kit (Colorimetric) (96 tests)
- Catalog number:
- Category:
- -
- Supplier:
- EpigenTek
- Gene target:
- EpiQuik HDAC9 Assay Kit (Colorimetric) (96 assays)
Related genes to: EpiQuik HDAC9 Assay Kit (Colorimetric) (96 assays)
- Gene:
- HDAC9 NIH gene
- Name:
- histone deacetylase 9
- Previous symbol:
- -
- Synonyms:
- KIAA0744, HDAC, MITR, HD7, HDAC7B
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-06
- Date modifiied:
- 2015-09-11
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- Primary cardiac tumours are relatively uncommon (75% are benign). Across the other 25%, representing malignant neoplasia, sarcomas account for 75-95%, and primary cardiac intimal sarcoma (PCIS) is one of the rarest findings. We aimed to present a comprehensive review and practical considerations from a multidisciplinary perspective with regard to the most recent published data in the specific domain of PCIS. We covered the issues of awareness amid daily practice clinical presentation to ultra-qualified management in order to achieve an adequate diagnosis and prompt intervention, also emphasizing the core role of immunostaining and genetic analysis. An additional base for practical points was provided by a novel on-point clinical vignette with MDM2-positive status. According to our methods (PubMed database search of full-length, English publications from January 2021 to March 2023), we identified three studies and 23 single case reports represented by 22 adults (male-to-female ratio of 1.2; male population with an average age of 53.75 years, range: 35-81; woman mean age of 55.5 years, range: 34-70) and a 4-year-old child. The tumour-related clinical picture was recognized in a matter of one day to ten months on first admission. These non-specific data (with a very low index of suspicion) included heart failure at least NYHA class II, mitral regurgitation and pulmonary hypertension, acute myocardial infarction, ischemic stroke, obstructive shock, and paroxysmal atrial fibrillation. Awareness might come from other complaints such as (most common) dyspnoea, palpitation, chest pressure, cough, asthenia, sudden fatigue, weakness, malaise, anorexia, weight loss, headache, hyperhidrosis, night sweats, and epigastric pain. Two individuals were initially misdiagnosed as having endocarditis. A history of prior treated non-cardiac malignancy was registered in 3/23 subjects. Distant metastasis as the first step of detection ( = 2/23; specifically, brain and intestinal) or during follow-up ( = 6/23; namely, intestinal, brain and bone, in two cases for each, and adrenal) required additional imagery tools (26% of the patients had distant metastasis). Transoesophageal echocardiography, computed tomography (CT), magnetic resonance imagery, and even F-FDG positronic emission tomography-CT (which shows hypermetabolic lesions in PCIS) represent the basis of multimodal tools of investigation. Tumour size varied from 3 cm to ≥9 cm (average largest diameter of 5.5 cm). The most frequent sites were the left atrium followed by the right ventricle and the right atrium. Post-operatory histological confirmation was provided in 20/23 cases and, upon tumour biopsy, in 3/23 of them. The post-surgery maximum free-disease interval was 8 years, the fatal outcome was at the earliest two weeks since initial admission. analysis was provided in 7/23 subjects in terms of MDM2-positive status (two out of three subjects) at immunohistochemistry and amplification (four out of five subjects) at genetic analysis. Additionally, another three studies addressed PCISs, and two of them offered specific / assays ( = 35 patients with PCISs); among the provided data, we mention that one cohort ( = 20) identified a rate of 55% with regard to amplification in intimal sarcomas, and this correlated with a myxoid pattern; another cohort ( = 15) showed that MDM2-positive had a better prognostic than MDM2-negative immunostaining. To summarize, amplification and co-amplification, for example, with , CDK4, , , , , , , and , might improve the diagnosis of PCIS in addition to immunostaining since 10-20% of these tumours are MDM2-negative. Further studies are necessary to highlight applicability as a prognostic factor and as an element to be taken into account amid multi-layered management in an otherwise very aggressive malignancy. - Source: PubMed
Publication date: 2024/04/28
Nistor ClaudiuCarsote MaraCucu Anca-PatiStanciu MihaelaPopa Florina LigiaCiuche AdrianCiobica Mihai-Lucian - Inhaled corticosteroids (ICS) are efficacious in the treatment of asthma, which affects more than 300 million people in the world. While genome-wide association studies have identified genes involved in differential treatment responses to ICS in asthma, few studies have evaluated the effects of combined rare and common variants on ICS response among children with asthma. Among children with asthma treated with ICS with whole exome sequencing (WES) data in the PrecisionLink Biobank (91 White and 20 Black children), we examined the effect and contribution of rare and common variants with hospitalizations or emergency department visits. For 12 regions previously associated with asthma and ICS response (, , , , , , , , , , ), we used the combined sum test for the sequence kernel association test (SKAT) adjusting for age, sex, and BMI and stratified by race. Validation was conducted in the Biorepository and Integrative Genomics (BIG) Initiative (83 White and 134 Black children). Using a Bonferroni threshold for the 12 regions tested (i.e., 0.05/12 = 0.004), was significantly associated with ICS response for the combined effect of rare and common variants (-value = 0.003) among White children in the PrecisionLink Biobank and replicated in the BIG Initiative (-value = 0.02). Using WES data, the combined effect of rare and common variants for was associated with ICS response among asthmatic children in the PrecisionLink Biobank and replicated in the BIG Initiative. This proof-of-concept study demonstrates the power of biobanks of pediatric real-life populations in asthma genomic investigations. - Source: PubMed
Publication date: 2024/03/28
Voorhies KirstenMohammed AkramChinthala LokeshKong Sek WonLee In-HeeKho Alvin TMcGeachie MichaelMandl Kenneth DRaby BenjaminHayes MelanieDavis Robert LWu Ann ChenLutz Sharon M - Histone deacetylase (HDAC) 9 is a negative regulator of adipogenic differentiation, which is required for maintenance of healthy adipose tissues. We reported that expression is upregulated in adipose tissues during obesity, in conjunction with impaired adipogenic differentiation, adipocyte hypertrophy, insulin resistance, and hepatic steatosis, all of which were alleviated by global genetic deletion of . Here, we developed a novel transgenic (TG) mouse model to test whether overexpression of is sufficient to induce adipocyte hypertrophy, insulin resistance, and hepatic steatosis in the absence of obesity. HDAC9 TG mice gained less body weight than wild-type (WT) mice when fed a standard laboratory diet for up to 40 weeks, which was attributed to reduced fat mass (primarily inguinal adipose tissue). There was no difference in insulin sensitivity or glucose tolerance in 18-week-old WT and HDAC9 TG mice; however, at 40 weeks of age, HDAC9 TG mice exhibited impaired insulin sensitivity and glucose intolerance. Tissue histology demonstrated adipocyte hypertrophy, along with reduced numbers of mature adipocytes and stromovascular cells, in the HDAC9 TG mouse adipose tissue. Moreover, increased lipids were detected in the livers of aging HDAC9 TG mice, as evaluated by oil red O staining. In conclusion, the experimental aging HDAC9 TG mice developed adipocyte hypertrophy, insulin resistance, and hepatic steatosis, independent of obesity. This novel mouse model may be useful in the investigation of the impact of overexpression associated with metabolic and aging-related diseases. - Source: PubMed
Publication date: 2024/04/18
Veerapaneni PraneetGoo BrandeeAhmadieh SamahShi HongKim David SOgbi MouradCave StephenChouhaita RonnieCyriac NicoleFulton David JVerin Alexander DChen WeiqinLei YunLu Xin-YunKim Ha WonWeintraub Neal L - Ischemic stroke (IS) is a major cause of mortality and disability worldwide. Inflammatory response is crucial in the pathogenesis of tissue injury in cerebral infarction. Arctium lappa leaves are traditionally used to treat IS. - Source: PubMed
Publication date: 2024/04/07
Wang MengmengLi QingxiaRen BingjieHao DanliGuo HuiYang LianheWang ZhiminDai Liping - Coronary artery spasm (CAS) is a frequent finding in patients presenting with angina pectoris. Although the pathogenesis of CAS is incompletely understood, previous studies suggested a genetic contribution. Our study aimed to elucidate genetic variants in a cohort of European patients with angina and unobstructed coronary arteries who underwent acetylcholine (ACh) provocation testing. - Source: PubMed
Publication date: 2024/04/18
Tremmel RomanMartínez Pereyra ValeriaBroders InciferSchaeffeler ElkeHoffmann PerNöthen Markus MBekeredjian RaffiSechtem UdoSchwab MatthiasOng Peter