ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Known as:
- Enzyme-linked immunosorbent assay test AGTR1,Angiotensin II classification-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Catalog number:
- E1658Rb
- Product Quantity:
- 96T
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- ELISA AGTR1 Angiotensin type-1 receptor AT1 Oryctolagus cuniculus Rabbit Type-1 angiotensin
Related genes to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- Gene:
- AGTR1 NIH gene
- Name:
- angiotensin II receptor type 1
- Previous symbol:
- AGTR1B
- Synonyms:
- AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2017-07-07
Related products to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
Related articles to: ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor
- To analyze the gene variants of the renin-angiotensin-aldosterone system (RAAS) and determine their association with the severity and outcome of coronavirus disease 19 (COVID-19). - Source: PubMed
Publication date: 2024/04/30
Martinez-Fierro M LPerez-Favila AAlfaro S M ZorrillaOropeza-de Lara S AGarza-Veloz IHernandez-Marquez L SGutierrez-Vela E FDelgado-Enciso IRodriguez-Sanchez I P - Despite advancements in colorectal cancer (CRC) treatment, the prognosis remains unfavorable for patients with distant liver metastasis. Fluorescence molecular imaging with specific probes is increasingly used to guide CRC surgical resection in real-time and treatment planning. Here, we demonstrate the targeted imaging capacity of an MPA-PEG-N-Ang II probe labeled with near-infrared (NIR) fluorescent dye targeting the angiotensin II (Ang II) type 1 receptor (AGTR1) that is significantly upregulated in CRC. MPA-PEG-N-Ang II was highly selective and specific to in vitro tumor cells and in vivo tumors in a mouse CRC xenograft model. The favorable ex vivo imaging and in vivo biodistribution of MPA-PEG-N-Ang II afforded tumor-specific accumulation with low background and >10 contrast tumor-to-colorectal values in multiple subcutaneous CRC models at 8 h following injection. Biodistribution analysis confirmed the probe's high uptake in HT29 and HCT116 orthotopic and liver metastatic models of CRC with signal-to-noise ratio (SNR) values of tumor-to-colorectal and -liver fluorescence of 5.8 ± 0.6, 5.3 ± 0.7, and 2.7 ± 0.5, 2.6 ± 0.5, respectively, enabling high-contrast intraoperative tumor visualization for surgical navigation. Given its rapid tumor targeting, precise tumor boundary delineation, durable tumor retention and docking study, MPA-PEG-N-Ang II is a promising high-contrast imaging agent for the clinical detection of CRC. - Source: PubMed
Publication date: 2024/04/27
Zhou KunchengLi GangPan RongbinXin SulinWen WeijieWang HuiyiLuo ChaoHan Ray P SGu YueqingTu Yuanbiao - Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification. - Source: PubMed
Publication date: 2024/04/22
Al-Maraghi AljaziAamer WaleedZiab MubarakAliyev ElbayElbashir NajwaHussein SuraPalaniswamy SasirekhaAnand DhullipalaLove Donald RCharles AdrianA S Akil AmmiraFakhro Khalid A - The pathogenesis and prognosis of patients with acute myocardial infarction (AMI) may be influenced by both genetic and environmental factors. Findings on the relationship of polymorphisms in various genes encoding the renin-angiotensin-aldosterone system with coronary artery lesions and mortality in AMI patients are inconsistent. The aim of this study was to determine whether the AGTR1 A1166C genetic polymorphism affects coronary artery lesions and 1-year mortality in post-AMI patients. Patients with their first AMI admitted to Cho Ray Hospital, Vietnam, from January 2020 to August 2021 were enrolled in this prospective clinical study. All participants underwent invasive coronary angiography and were identified as having the genotypes of AGTR1 A1166C by way of a polymerase chain reaction method. All patients were followed up for all-cause mortality 12 months after AMI. The association of the AGTR1 A1166C polymorphism with coronary artery lesions and 1-year mortality was evaluated using logistic regression and Cox regression analysis, respectively. Five hundred and thirty-one AMI patients were recruited. The mean age was 63.9 ± 11.6 years, and 71.6% of the patients were male. There were no significant differences in the location and number of diseased coronary artery branches between the AA and AC+CC genotypes. The AC and CC genotypes were independently associated with ≥ 90% diameter stenosis of the left anterior descending (LAD) artery (odds ratio = 1.940; 95% confidence interval (CI): 1.059-3.552, p = 0.032). The 1-year all-cause mortality rate difference between patients with the AC and CC genotypes versus those with the AA genotype was not statistically significant (hazard ratio = 1.000, 95% CI: 0.429-2.328, p = 1.000). The AGTR1 A1166C genetic polymorphism is associated with very severe luminal stenosis of the LAD but not with mortality in AMI patients. - Source: PubMed
Publication date: 2024/04/18
Tran Duy CongLe Linh Hoang GiaThai Truc ThanhVan Hoang SyDo Minh DucTruong Binh Quang - Glioblastoma is a highly aggressive disease with poor survival outcomes. An emerging body of literature links the role of the renin-angiotensin system (RAS), well-known for its function in the cardiovascular system, to the progression of cancers. We studied the expression of RAS-related genes (, , , , , and ) in The Cancer Genome Atlas (TCGA) glioblastoma cohort, their relationship to patient survival, and association with tumour microenvironment pathways. The expression of RAS genes was then examined in 12 patient-derived glioblastoma cell lines treated with chemoradiation. In cases of glioblastoma within the TCGA, , , , and had consistent expressions across samples, while and were lowly expressed. High expression of was independently associated with lower progression-free survival (PFS) ( = 0.01) and had a non-significant trend for overall survival (OS) after multivariate analysis ( = 0.095). The combined expression of RAS receptors (, , and ) was positively associated with gene pathways involved in hypoxia, microvasculature, stem cell plasticity, and the molecular characterisation of glioblastoma subtypes. In patient-derived glioblastoma cell lines, and were upregulated after chemoradiotherapy and correlated with an increase in expression. This data suggests the RAS is correlated with changes in the tumour microenvironment and associated with glioblastoma survival outcomes. - Source: PubMed
Publication date: 2024/04/05
Lozinski MathewLumbers Eugenie RBowden Nikola AMartin Jennifer HFay Michael FPringle Kirsty GTooney Paul A