Cryo tube 2.0ml cryo tube
(With screw cup)
- Known as:
- Cryo tube 2.0ml cryo tube
(With screw cup)
- Catalog number:
- ZD1038
- Product Quantity:
-
5000pc/carton
- Category:
- -
- Supplier:
- Zenplastic
- Gene target:
- Cryo tube 2.0ml cryo
(With screw cup)
Related genes to: Cryo tube 2.0ml cryo tube
(With screw cup)
- Gene:
- TSC2 NIH gene
- Name:
- TSC complex subunit 2
- Previous symbol:
- TSC4
- Synonyms:
- tuberin, LAM, PPP1R160
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: Cryo tube 2.0ml cryo tube
(With screw cup)
Related articles to: Cryo tube 2.0ml cryo tube
(With screw cup)
- To determine the prevalence of tuberous sclerosis complex (TSC) in the paediatric Saudi population and to characterise the range of clinical symptoms, neurocutaneous findings, neuroimaging results, and complications of the disease. - Source: PubMed
Almuqbil MohammedAldoohan WaadAlhinti SaraAlmahmoud NoraAbdulmajeed ImadAlkhodair RayanKashgari AmnaBaarmah DuaaAltwaijri WaleedAlrumayyan Ahmad - Subependymal giant cell astrocytoma (SEGA) is a rare circumscribed astrocytic glioma that occurs in approximately 25% of all tuberous sclerosis (TSC) cases. Herein, we discuss an atypical presentation of SEGA, including the genetic alterations, impact on clinical presentation, and the determinants of each medical and surgical treatment option. A 14-year-old girl presented with intermittent headache and a right intraventricular mass originating near the foramen of Monro. The tumor's proximity to critical structures necessitated maximum safe resection, which improved her symptoms. Histological findings indicated SEGA, and genetic sequencing revealed a mutation. However, complete clinical and radiological evaluations failed to reveal TSC. Two months later, a new subependymal nodule was incidentally found. She had a recurrent left occipital horn lesion and diffuse smooth leptomeningeal enhancement with no spine drop metastases. She was administered everolimus as the tumor was considered unresectable. Subsequent imaging revealed a reduction in both residual and new lesions. - Source: PubMed
Alassiri Ali HAlfayea Turki MAljared Tariq IAlenezi Khaled R - Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While ethnic differences in driver gene mutations have been documented, the South American population remains understudied at the genomic level, despite facing a rising burden of CRC. We analyzed tumors of 40 Chilean CRC patients (Chp) using next-generation sequencing and compared them to data from mainly Caucasian cohorts (TCGA and MSK-IMPACT). We identified 388 mutations in 96 out of 135 genes, with (45%), (30%), (22.5%), (20%), and (20%) being the most frequently mutated. mutations were associated with right colon cancer (44.44% in RCRC vs. 6.45% in LCRC, -value = 0.016), and overall frequency was higher compared to TCGA (-value = 1.847 × 10) and MSK-IMPACT cohorts (-value = 3.062 × 10). Limited sample size restricts definitive conclusions, but our data suggest potential differences in driver mutations for Chilean patients, being that the RTK-RAS oncogenic pathway is less affected and the PI3K pathway is more altered in Chp compared to TCGA (45% vs. 25.56%, respectively). The prevalence of actionable pathways and driver mutations can guide therapeutic choices, but can also impact treatment effectiveness. Thus, these findings warrant further investigation in larger Chilean cohorts to confirm these initial observations. Understanding population-specific driver mutations can guide the development of precision medicine programs for CRC patients. - Source: PubMed
Publication date: 2024/04/25
Tapia-Valladares CamiloValenzuela GuillermoGonzález EvelinMaureira IgnacioToro JessicaFreire MatíasSepúlveda-Hermosilla GonzaloAmpuero DiegoBlanco AlejandroGallegos IvánMorales FernandaErices José IBarajas OlgaAhumada MónicaContreras Héctor RGonzález JaimeArmisén RicardoMarcelain Katherine - Tuberous sclerosis complex (TSC) is a genetic disorder caused by a or gene variation characterized by widespread hamartomas in organs such as the skin, brain, heart, lungs, liver, and kidneys. - Source: PubMed
Publication date: 2024/02/16
Lai YujieMa YuanyeLuo BiaoLong Yan - - Source: PubMed
Publication date: 2024/04/28
Fu JiahuiLiang PeiliZheng YingchunXu CailingXiong FuYang Fang