CLIA ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Dioxin receptor, nuclear translocator,HIF-1-beta,HIF1-beta,Hypoxia-inducible factor 1-beta,Oryctolagus cuniculus,Rabbit
- Known as:
- CLIA ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Dioxin receptor, nuclear translocator,HIF-1-b,HIF1-b,Hypoxia-inducible factor 1-b,Oryctolagus cuniculus,Rabbit
- Catalog number:
- U2286Rb
- Product Quantity:
- 96T
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- CLIA ARNT protein Aryl hydrocarbon receptor nuclear translocator Dioxin HIF-1-beta HIF1-beta Hypoxia-inducible factor 1-beta Oryctolagus cuniculus Rabbit
Related genes to: CLIA ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Dioxin receptor, nuclear translocator,HIF-1-beta,HIF1-beta,Hypoxia-inducible factor 1-beta,Oryctolagus cuniculus,Rabbit
- Gene:
- ARNT NIH gene
- Name:
- aryl hydrocarbon receptor nuclear translocator
- Previous symbol:
- -
- Synonyms:
- HIF-1beta, bHLHe2
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-22
- Date modifiied:
- 2016-10-05
- Gene:
- ERO1B NIH gene
- Name:
- endoplasmic reticulum oxidoreductase 1 beta
- Previous symbol:
- ERO1LB
- Synonyms:
- ERO1-L(beta), Ero1beta
- Chromosome:
- 1q42.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-25
- Date modifiied:
- 2016-10-05
- Gene:
- HNF1B NIH gene
- Name:
- HNF1 homeobox B
- Previous symbol:
- TCF2
- Synonyms:
- LFB3, VHNF1, HNF1beta, MODY5
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-28
- Date modifiied:
- 2015-09-07
- Gene:
- LIPI NIH gene
- Name:
- lipase I
- Previous symbol:
- -
- Synonyms:
- PRED5, LPDL, CT17, mPA-PLA1beta, PLA1C
- Chromosome:
- 21q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-01
- Date modifiied:
- 2016-01-29
- Gene:
- NR5A2 NIH gene
- Name:
- nuclear receptor subfamily 5 group A member 2
- Previous symbol:
- FTF
- Synonyms:
- FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2, LRH1
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-13
- Date modifiied:
- 2018-02-14
Related products to: CLIA ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Dioxin receptor, nuclear translocator,HIF-1-beta,HIF1-beta,Hypoxia-inducible factor 1-beta,Oryctolagus cuniculus,Rabbit
Related articles to: CLIA ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Dioxin receptor, nuclear translocator,HIF-1-beta,HIF1-beta,Hypoxia-inducible factor 1-beta,Oryctolagus cuniculus,Rabbit
- Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in mice treated with carbon tetrachloride (CCl) and in human hepatic stellate cells line LX2. Mice received CCl 5 μL/g body weight i.p. twice a week for 4 or 6 weeks. Melatonin was given at 5 or 10 mg/kg/day i.p., beginning 2 weeks after the start of CCl administration. Treatment with CCl resulted in fibrosis evidenced by the staining of α-smooth muscle actin (α-SMA) positive cells and a significant decrease of peroxisome proliferator-activated receptor (PPARα) expression. CCl led to a lower expression of brain and muscle Arnt-like protein 1 (BMAL1), circadian locomotor output cycles kaput (CLOCK), period 1-3 (PER1, 2, and 3), cryptochrome 1 and 2 (CRY1 and 2) and the retinoic acid receptor-related orphan receptor (RORα). The expression of the nuclear receptor REV-ERBα showed a significant increase. Melatonin significantly prevented all these changes. We also found that melatonin (100 or 500 μM) potentiated the inhibitory effect of REV-ERB ligand SR9009 on α-SMA and collagen1 expression and increased the expression of PPARα in LX2 cells. Analysis of circadian clock machinery revealed that melatonin or SR9009 exposure upregulated BMAL1, CLOCK, PER2, CRY1, and RORα expression, with a higher effect of combined treatment. Findings from this study give new insight into molecular pathways accounting for the protective effect of melatonin in liver fibrosis. - Source: PubMed
Publication date: 2018/05/28
González-Fernández BárbaraSánchez Diana ICrespo IreneSan-Miguel Beatrizde Urbina Juan OrtizGonzález-Gallego JavierTuñón María J