CD1a, some X w_CD1d, Dendritic Cell, Cortical Thymocyte, Clone JPM30, Mab anti_Human; frzn_prfn, IH_No WB
- Known as:
- CD1a, X w_CD1d, Dendritic Cell, Cortical Thymocyte, Clone JPM30, Mab anti_Human; frzn_prfn, IH_No Western Blot
- Catalog number:
- MEDCLA475-01
- Product Quantity:
- 0.1 ml.
- Category:
- -
- Supplier:
- Accu
- Gene target:
- CD1a some w_CD1d Dendritic Cell Cortical Thymocyte Clone JPM30 Mab anti_Human; frzn_prfn IH_No
Related genes to: CD1a, some X w_CD1d, Dendritic Cell, Cortical Thymocyte, Clone JPM30, Mab anti_Human; frzn_prfn, IH_No WB
- Gene:
- CD1A NIH gene
- Name:
- CD1a molecule
- Previous symbol:
- CD1
- Synonyms:
- -
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2017-07-07
Related products to: CD1a, some X w_CD1d, Dendritic Cell, Cortical Thymocyte, Clone JPM30, Mab anti_Human; frzn_prfn, IH_No WB
Related articles to: CD1a, some X w_CD1d, Dendritic Cell, Cortical Thymocyte, Clone JPM30, Mab anti_Human; frzn_prfn, IH_No WB
- Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a-positive/Langerin (CD207)-positive histiocytes and inflammatory infiltrate that can cause local tissue damage and systemic inflammation. Clinical presentations range from single lesions with minimal impact to life-threatening disseminated disease. Therapy for systemic LCH has been established through serial trials empirically testing different chemotherapy agents and durations of therapy. However, fewer than 50% of patients who have disseminated disease are cured with the current standard-of-care vinblastine/prednisone/(mercaptopurine), and treatment failure is associated with long-term morbidity, including the risk of LCH-associated neurodegeneration. Historically, the nature of LCH-whether a reactive condition versus a neoplastic/malignant condition-was uncertain. Over the past 15 years, seminal discoveries have broadly defined LCH pathogenesis; specifically, activating mitogen-activated protein kinase pathway mutations (most frequently, BRAFV600E) in myeloid precursors drive lesion formation. LCH therefore is a clonal neoplastic disorder, although secondary inflammatory features contribute to the disease. These paradigm-changing insights offer a promise of rational cures for patients based on individual mutations, clonal reservoirs, and extent of disease. However, the pace of clinical trial development behind lags the kinetics of translational discovery. In this review, the authors discuss the current understanding of LCH biology, clinical characteristics, therapeutic strategies, and opportunities to improve outcomes for every patient through coordinated agent prioritization and clinical trial efforts. - Source: PubMed
Publication date: 2024/04/30
Bielamowicz KevinDimitrion PeterAbla OussamaBomken SimonCampbell PatrickCollin MatthewDegar BarbaraDiamond Eli LEckstein Olive SEl-Mallawany NaderFluchel MarkGoyal GauravHenry Michael MHermiston MichelleHogarty MichaelJeng MichaelJubran RimaLubega JosephKumar AshishLadisch StephanMcClain Kenneth LMerad MiriamMi Qing-ShengParsons D WilliamsPeckham-Gregory ErinPicarsic JenniferPrudowsky Zachary DRollins Barrett JShaw Peter HWistinghausen BirteRodriguez-Galindo CarlosAllen Carl E - The insights provided by in-situ detection of immune cells within hepatocellular carcinoma (HCC) might present information on patient outcomes. Studies investigating the expression and localization of immune cells within tumor tissues are associated with several challenges, including a lack of precise annotation for tumor regions and random selection of microscopic fields of view. QuPath is an open-source, user-friendly software that could meet the growing need for digital pathology in whole-slide image (WSI) analysis. The infiltration of HCC and adjacent tissues by CD1a+ immature dendritic cells (iDCs), CD117+ mast cells, and NKp46+ natural killer cells (NKs) cells was assessed immunohistochemically in representative specimens of 67 patients with HCC who underwent curative resection. The area fraction (AF) of positively stained cells was assessed automatically in WSIs using QuPath in the tumor center (TC), inner margin (IM), outer margin (OM), and peritumor (PT) area. The prognostic significance of immune cells was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). The AF of mast cells was significantly greater than the AF of NKs, and the AF of iDCs was significantly lower compared to NKs in each region of interest. High AFs of mast cells in the IM and PT areas were associated with longer DFS. In addition, high AF of mast cells in IM was associated with longer OS. Computer-assisted analysis using this software is a suitable tool for obtaining prognostic information for tumor-infiltrating immune cells (iDCs, mast cells, and NKs) in different regions of HCC after resection. Mast cells displayed the greatest AF in all regions of interest (ROIs). Mast cells in the peritumor region and IM showed a positive prognostic significance. - Source: PubMed
Publication date: 2024/04/12
Ali EsraaČervenková LenkaPálek RichardAmbrozkiewicz FilipPavlov SergiiYe WenjingHošek PetrDaum OndrejLiška VáclavHemminki KariTrailin Andriy - Erdheim-Chester disease (ECD) is a rare multisystemic disease characterized by the infiltration of multiple organs by foamy CD68 + CD1a-histiocytes. The genetic background consists of gain-of-function somatic mutations in the mitogen-activated protein kinase pathway. The purpose of the present paper is to make a contribution to the scientific literature on ECD by reporting our experience with a complex clinical case report, along with a concise review of the literature. We discussed the unusual clinical presentation, the complex diagnostic process and the comparison with other published cases. - Source: PubMed
Gagliardo Carola MGiammanco AntoninaVaglio AugustoPegoraro FrancescoCefalù Angelo BAverna MaurizioNoto Davide - Carcinoma ex-pleomorphic adenoma (CEXPA) represents a malignant transformation from a recurrent or primary pleomorphic adenoma (PA), and the immune response may be essential in this process. Therefore, in this study, we aimed to identify and quantify subpopulations of dendritic cells (DCs) in CEXPA, residual PA in CEXPA (rPA), and PA. - Source: PubMed
Publication date: 2024/04/24
Machado Bárbara AzevedoGama-Cuellar Ana GuadalupeScarini João FigueiraDíaz Katya PulidoMariano Fernanda VivianeAlbuquerque-Junior Ricardo Luiz CavalcantiGondak Rogério - Langerhans cell histiocytosis (LCH) of the stomach is rare. Moreover, it is usually found in pediatric patients with systemic diseases and may be associated with a poor prognosis. Solitary gastric LCH in adults is extremely rare and is often misdiagnosed or missed. The aim of our study was to review cases of gastric LCH and explore the characteristics of the disease further. A retrospective study of all patients admitted with solitary gastric LCH was conducted between 2013 and 2023. Clinical manifestations, endoscopic and pathological features, immunophenotypes, and molecular changes were collected from medical records. We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, all lesions expressed CD1a, S-100, langerin, and cyclinD1. One case showed diffuse BRAF V600E positivity. Follow-up data were available for all patients from 4 to 36 months, and all patients were alive without recurrence or progress at the time of manuscript preparation. Combined with previously reported data, solitary adult gastric LCH is more common in male patients, most of whom are asymptomatic or exhibit only mild gastrointestinal symptoms, with a good prognosis. Endoscopy often reveals solitary polyps or protruding lesions; rare cases may progress to multifocal/multisystem lesions, necessitating long-term close follow-up. - Source: PubMed
Publication date: 2024/04/23
Zhao JianminLi YanleiZhang YanlinMei XueLiu WeiLi Yinghong