C1S, pro- and activated enzyme, Mab anti-Human
- Known as:
- C1S, pro- activated enzyme, Mab (anti-) to-Human
- Catalog number:
- abs002-09
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Accurate
- Gene target:
- C1S pro- and activated enzyme Mab anti-Human
Ask about this productRelated genes to: C1S, pro- and activated enzyme, Mab anti-Human
- Gene:
- HTRA1 NIH gene
- Name:
- HtrA serine peptidase 1
- Previous symbol:
- PRSS11
- Synonyms:
- HtrA, IGFBP5-protease, ARMD7
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
- Gene:
- KLK15 NIH gene
- Name:
- kallikrein related peptidase 15
- Previous symbol:
- -
- Synonyms:
- HSRNASPH, ACO, prostinogen
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2016-11-15
- Gene:
- PCSK1N NIH gene
- Name:
- proprotein convertase subtilisin/kexin type 1 inhibitor
- Previous symbol:
- -
- Synonyms:
- SAAS, SgVIII, SCG8, proSAAS, PEN, BigLEN
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-30
- Date modifiied:
- 2016-05-09
- Gene:
- PDHX NIH gene
- Name:
- pyruvate dehydrogenase complex component X
- Previous symbol:
- -
- Synonyms:
- E3BP, proX, PDX1, OPDX, DLDBP
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-24
- Date modifiied:
- 2015-11-20
- Gene:
- PRELP NIH gene
- Name:
- proline and arginine rich end leucine rich repeat protein
- Previous symbol:
- -
- Synonyms:
- SLRR2A, prolargin
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-09-24
- Date modifiied:
- 2016-10-05
Related products to: C1S, pro- and activated enzyme, Mab anti-Human
Related articles to: C1S, pro- and activated enzyme, Mab anti-Human
- The establishment of left-right asymmetry is a fundamental process in animal development. Interference with this process leads to a range of disorders collectively known as laterality defects, which manifest as abnormal arrangements of visceral organs. Among patients with laterality defects, congenital heart diseases (CHD) are prevalent. Through multiple model organisms, extant research has established that myosin-Id (MYO1D) deficiency causes laterality defects. This study investigated over a hundred cases and identified a novel biallelic variant of MYO1D (NM_015194: c.1531G>A; p.D511N) in a consanguineous family with complex CHD and laterality defects. Further examination of the proband revealed asthenoteratozoospermia and shortened sperm. Afterward, the effects of the D511N variant and another known MYO1D variant (NM_015194: c.2293C>T; p.P765S) were assessed. The assessment showed that both enhance the interaction with β-actin and SPAG6. Overall, this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in humans. Furthermore, this research established a connection between sperm defects and MYO1D variants. It offers guidance for exploring infertility and reproductive health concerns. The findings provide a critical basis for advancing personalized medicine and genetic counseling. - Source: PubMed
Publication date: 2024/04/30
Yuan ZhuangzhuangZhu XinXie XiaohuiWang ChenyuGu HengYang JunlinFan LiangliangXiang RongYang YifengTan Zhiping - The quality of sperm significantly influences the reproductive efficiency of pig herds. High-quality sperm is necessary for efficient fertilization and to maximize the litter numbers in commercial pig farming. However, the understanding of genes regulating porcine sperm motility and viability is limited. In this study, we validated porcine sperm/Sertoli-specific promoters through the luciferase reporter system and identified vital genes for sperm quality via loss-of-function means. Further, the shRNAs driven by the ACE and SP-10 promoters were used to knockdown the SPAG6 and PPP1CC genes which were provisionally important for sperm quality. We assessed the effects of SPAG6 and PPP1CC knockdown on sperm motility by using the sperm quality analyzer and flow cytometry. The results showed that the ACE promoter is active in both porcine Sertoli cells and sperms, whereas the SP-10 promoter is operating exclusively in sperm cells. Targeted interference with SPAG6 and PPP1CC expression in sperm cells decreases the motility and increases apoptosis rates in porcine sperms. These findings not only offer new genetic tools for targeting male germ cells but also highlight the crucial roles of SPAG6 and PPP1CC in porcine sperm function. - Source: PubMed
Publication date: 2024/02/28
Ren HongyanZhang YandiBi YanzhenWang HengFang GuijieZhao Pengxiang - Epigenetic modifications are critical in precisely regulating gene expression. The common carp () is an economically important fish species, and females exhibit faster growth rates than males. However, the studies related to epigenetic modifications in the common carp gonads are limited. In this study, we conducted the Assay for Transposase Accessible Chromatin sequencing (ATAC-seq) and Bisulfite sequencing (BS-seq) to explore the roles of epigenetic modifications in the common carp gonads. We identified 84,207 more accessible regions and 77,922 less accessible regions in ovaries compared to testes, and some sex-biased genes showed differential chromatin accessibility in their promoter regions, such as and . Motif enrichment analysis showed that transcription factors (TFs) associated with embryonic development and cell proliferation were heavily enriched in ovaries, and the TFs Foxl2 and SF1 were only identified in ovaries. We also analyzed the possible regulations between chromatin accessibility and gene expression. By BS-seq, we identified 2087 promoter differentially methylated genes (promoter-DMGs) and 5264 gene body differentially methylated genes (genebody-DMGs) in CG contexts. These genebody-DMGs were significantly enriched in the Wnt signaling pathway, TGF-beta signaling pathway, and GnRH signaling pathway, indicating that methylation in gene body regions could play an essential role in sex maintenance, just like methylation in promoter regions. Combined with transcriptomes, we revealed that the expression of , , and was negatively correlated with their methylation levels in promoter regions. Our study on the epigenetic modifications of gonads contributes to elucidating the molecular mechanism of sex differentiation and sex maintenance in the common carp. - Source: PubMed
Publication date: 2023/12/25
Hou MingxiWang QiZhao RanCao YimingZhang JinSun XiaoqingYu ShuangtingWang KaikuoChen YingjieZhang YanLi Jiongtang - Adult B-cell acute lymphoblastic leukemia (B-ALL) prognosis remains unsatisfactory, and searching for new therapeutic targets is crucial for improving patient prognosis. Sperm-associated antigen 6 (SPAG6), a member of the cancer-testis antigen family, plays an important role in tumors, especially hematologic tumors; however, it is unknown whether SPAG6 plays a role in adult B-ALL. In this study, we demonstrated for the first time that SPAG6 expression was up-regulated in the bone marrow of adult B-ALL patients compared to healthy donors, and expression was significantly reduced in patients who achieved complete remission (CR) after treatment. In addition, patients with high SPAG6 expression were older (≥ 35 years; P = 0.015), had elevated white blood cell counts (WBC > 30 × 10/L; P = 0.021), and a low rate of CR (P = 0.036). We explored the SPAG6 effect on cell function by lentiviral transfection of adult B-ALL cell lines BALL-1 and NALM-6, and discovered that knocking down SPAG6 significantly inhibited cell proliferation and promoted apoptosis. We identified that SPAG6 knockdown might regulate cell proliferation and apoptosis via the transforming growth factor-β (TGF-β)/Smad signaling pathway. - Source: PubMed
Publication date: 2023/12/26
Zhao BeibeiYin JiaxiuDing LiLuo JieLuo JingMu JiaoPan ShiruiDu JuanZhong YiruiZhang LinyiLiu Lin - There are likely to be hundreds of monogenic forms of human male infertility. Whole genome sequencing (WGS) is the most efficient way to make progress in mapping the causative genetic variants, and ultimately improve clinical management of the disease in each patient. Recruitment of consanguineous families is an effective approach to ascertain the genetic forms of many diseases. - Source: PubMed
Publication date: 2023/12/10
Khan Muhammad RiazAkbari ArvandNicholas Thomas JCastillo-Madeen HelenAjmal MuhammadHaq Taqweem UlLaan MarisQuinlan Aaron RAhuja Jasvinder SShah Aftab AliConrad Donald F