C14orf124,Epimerase family protein SDR39U1,HCDI,Homo sapiens,Human,SDR39U1,Short-chain dehydrogenase_reductase family 39U member 1
- Known as:
- C14orf124,Epimerase family protein SDR39U1,HCDI,Homo sapiens,Human,SDR39U1,Short-epitope dehydrogenase_reductase family 39U member 1
- Catalog number:
- EIAAB10350
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- C14orf124 Epimerase family protein SDR39U1 HCDI Homo sapiens Human Short-chain dehydrogenase_reductase 39U member 1
Related genes to: C14orf124,Epimerase family protein SDR39U1,HCDI,Homo sapiens,Human,SDR39U1,Short-chain dehydrogenase_reductase family 39U member 1
- Gene:
- SDR39U1 NIH gene
- Name:
- short chain dehydrogenase/reductase family 39U member 1
- Previous symbol:
- C14orf124
- Synonyms:
- HCDI
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-17
- Date modifiied:
- 2016-01-20
Related products to: C14orf124,Epimerase family protein SDR39U1,HCDI,Homo sapiens,Human,SDR39U1,Short-chain dehydrogenase_reductase family 39U member 1
Related articles to: C14orf124,Epimerase family protein SDR39U1,HCDI,Homo sapiens,Human,SDR39U1,Short-chain dehydrogenase_reductase family 39U member 1
- Esophageal adenocarcinoma is the most common histological subtype of esophageal cancer in Western countries and shows poor prognosis with rapid growth. EAC is characterized by a strong male predominance and racial disparity. EAC is up to fivefold more common among Whites than Blacks, yet Black patients with EAC have poorer survival rates. The racial disparity remains largely unknown, and there is limited knowledge of mutations in EAC regarding racial disparities. We used whole-exome sequencing to show somatic mutation profiles derived from tumor samples from 18 EAC male patients. We identified three molecular subgroups based on the pre-defined esophageal cancer-specific mutational signatures. Group 1 is associated with age and NTHL1 deficiency-related signatures. Group 2 occurs primarily in Black patients and is associated with signatures related to DNA damage from oxidative stress and NTHL1 deficiency-related signatures. Group 3 is associated with defective homologous recombination-based DNA often caused by BRCA mutation in White patients. We observed significantly mutated race related genes (LCE2B in Black, SDR39U1 in White) were (q-value < 0.1). Our findings underscore the possibility of distinct molecular mutation patterns in EAC among different races. Further studies are needed to validate our findings, which could contribute to precision medicine in EAC. - Source: PubMed
Publication date: 2024/04/18
Lim HyeyeunGingras Marie-ClaudeZhao JingByun JinyoungCastro Patricia DTsavachidis SpiridonHu JianhongDoddapaneni HarshavardhanHan YiMuzny Donna MGibbs Richard AAmos Christopher IThrift Aaron P - N6-methyladenosine (mA) is tightly associated with the progression of pancreatic ductal adenocarcinoma (PDAC). Another prominent feature of PDAC is metabolic reprogramming, which provides sufficient nutrients to support rapid cell growth via the tumor microenvironment. However, the underlying influences of mA-associated metabolic genes on the PDAC microenvironment remain poorly understood. Therefore, we sought to construct a survival prediction model using mA-related genes to clarify the molecular characteristics of PDAC. - Source: PubMed
Publication date: 2022/10/21
Tan ZhenLiu JiangXu JinZhang BoYu XianjunWang WeiLiang Chen - Organophosphate flame retardants (OPFRs) are (re-)emergent environmental pollutants increasingly being used because of the restriction of other flame retardants. The chlorinated OPFR, tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is among those of highest environmental concern, but its potential effects in the marine environment have rarely been investigated. We exposed a widely used sentinel marine mussel species, Mytilus galloprovincialis, to 10 μg L of TDCPP during 28 days and studied: (i) the kinetics of bioaccumulation and elimination of the compound, (ii) the effect on two molecular biomarkers, glutathione S-transferase (GST) and acetylcholinesterase (AChE) activities, and (iii) proteomic alterations in the gills, following an isobaric labeling quantitative shotgun proteomic approach, at two exposure times (7 and 28 days). Uptake and elimination of TDCPP by mussels were very fast, and the bioconcentration factor of this compound in mussels was 147 L kg, confirming that this compound is not very bioaccumulative, as predicted by its chemical properties. GST activity was not affected by TDCPP exposure, but AChE activity was inhibited by TDCPP at both 7 and 28 days of exposure. Proteomic analysis revealed subtle effects of TDCPP in mussel gills, since few proteins (less than 2 % of the analysed proteome) were significantly affected by TDCPP, and effect sizes were low. The most relevant effects detected were the up-regulation of epimerase family protein SDR39U1, an enzyme that could be involved in detoxification processes, at both exposure times, and the down-regulation of receptor-type tyrosine-protein phosphatase N2-like (PTPRN2) after 7 days of exposure, which is involved in neurotransmitter secretion and might be related to the neurotoxicity described for this compound. Exposure time rather than TDCPP exposure was the most important driver of protein abundance changes, with 33 % of the proteome being affected by this factor, suggesting that stress caused by laboratory conditions could be an important confounding factor that needs to be controlled in similar ecotoxicology studies. Proteomic data are available via ProteomeXchange with identifier PXD019720. - Source: PubMed
Publication date: 2020/11/25
Sánchez-Marín PaulaVidal-Liñán LeticiaFernández-González Laura EmiliaMontes RosaRodil RosarioQuintana José BenitoCarrera MónicaMateos JesúsDiz Angel PBeiras Ricardo - Oligodendrocytes produce and maintain the myelin sheath of axons in the central nervous system. Because misassembled myelin sheaths have been associated with brain disorders such as multiple sclerosis and schizophrenia, recent advances have been made towards the description of the oligodendrocyte proteome. The identification of splice variants represented in the proteome is as important as determining the level of oligodendrocyte-associated proteins. Here, we used an oligodendrocyte proteome dataset deposited in ProteomeXchange to search against a customized protein sequence file containing computationally predicted splice variants. Our approach resulted in the identification of 39 splice variants, including one variant from the GTPase KRAS gene and another from the human glutaminase gene family. We also detected the mRNA expression of five selected splice variants and demonstrated that a fraction of these have their canonical proteins participating in direct protein-protein interactions. In conclusion, we believe our findings contribute to the molecular characterization of oligodendrocytes and may encourage other research groups working with central nervous system disorders to investigate the biological significance of these splice variants. The splice variants identified in this study may encode proteins that could be targeted in novel treatment strategies and diagnostic methods. - Source: PubMed
Publication date: 2016/05/21
Tavares RaphaelWajnberg GabrielScherer Nicole de MirandaPauletti Bianca AlvesCassoli Juliana SFerreira Carlos GilPaes Leme Adriana Francode Araujo-Souza Patricia SavioMartins-de-Souza DanielPassetti Fabio - To discover novel prognostic biomarkers in ovarian serous carcinomas. - Source: PubMed
Publication date: 2016/02/17
Willis ScooterVillalobos Victor MGevaert OlivierAbramovitz MarkWilliams CaseySikic Branimir ILeyland-Jones Brian