c-fos Proto-oncogene, Cellular oncogene fos, G0_G1 switch regulatory protein 7human, recombinant, Baculovirus
- Known as:
- c-fos Proto-oncogene, Cellular oncogene fos, G0_G1 switch regulatory protein 7human, Rec., Baculovirus
- Catalog number:
- PR-771
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Jena Bio
- Gene target:
- c-fos Proto-oncogene Cellular oncogene fos G0_G1 switch regulatory protein 7human recombinant Baculovirus
Related products to: c-fos Proto-oncogene, Cellular oncogene fos, G0_G1 switch regulatory protein 7human, recombinant, Baculovirus
Related articles to: c-fos Proto-oncogene, Cellular oncogene fos, G0_G1 switch regulatory protein 7human, recombinant, Baculovirus
- Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is the key to effectively relieving abdominal pain in IBS. Increasing evidence has confirmed that the thalamic nucleus reuniens (Re) and 5-hydroxytryptamine (5-HT) neurotransmitter system play an important role in the development of colorectal visceral pain, whereas the exact mechanisms remain largely unclear. In this study, we found that high expression of the 5-HT receptors in the Re glutamatergic neurons promoted colorectal visceral pain. Specifically, we found that neonatal maternal deprivation (NMD) mice exhibited visceral hyperalgesia and enhanced spontaneous synaptic transmission in the Re brain region. Colorectal distension (CRD) stimulation induced a large amount of c-Fos expression in the Re brain region of NMD mice, predominantly in glutamatergic neurons. Furthermore, optogenetic manipulation of glutamatergic neuronal activity in the Re altered colorectal visceral pain responses in CON and NMD mice. In addition, we demonstrated that 5-HT receptor expression on the Re glutamatergic neurons was upregulated and ultimately promoted colorectal visceral pain in NMD mice. These findings suggest a critical role of the 5HT receptors on the Re glutamatergic neurons in the regulation of colorectal visceral pain. - Source: PubMed
Publication date: 2024/05/13
Li DiDu HanQu Shu-TingWu Jing-LaiLi Yong-ChangXu Qi-YaChen XiaDai Xiao-XuanXu Ji-TianWang QianXu Guang-Yin - N-Ethylmaleimide (NEM), an agonist of the potassium chloride cotransporters 2 (KCC2) receptor, has been correlated with neurosuppressive outcomes, including decreased pain perception and the prevention of epileptic seizures. Nevertheless, its relationship with sleep-inducing effects remains unreported. - Source: PubMed
Publication date: 2024/05/07
Zhu SiqingShi JingjingZhang YiChen XuejunShi TongLi Liqin - Glaucoma is a common cause of blindness worldwide. Genetic effects are believed to contribute to the onset and progress of glaucoma, but the underlying pathological mechanisms are not fully understood. Here, we set out to introduce mutations into the gene, which is known as being the closely associated with glaucoma, in a human neuronal cell line . We introduced gene mutations with CRISPR/Cas9 into exons and introns into the gene. Both mutations strongly promoted neuronal cell death in normal culture conditions. RNA sequencing and pathway analysis revealed that the transcriptional factor Fos is a target molecule regulating overexpression. We demonstrated that gene mutation of is directly associated with neuronal cell vulnerability Additionally, Fos, which is a downstream signaling molecule of , may be a potential source of new therapeutic targets for neuronal degeneration in diseases such as glaucoma. - Source: PubMed
Publication date: 2024/05/03
Ohno-Oishi MichikoMeiai ZouSato KotaKanno SeiyaKawano ChihiroIshikawa MakotoNakazawa Toru - Endonasal endoscopic transsphenoidal surgery (TSS) and resection of pituitary adenomas is considered to be the gold standard treatment for Cushing's Disease (CD). Even with various recent advances in management, disease persistence and recurrences are common in these patients. The remission rate in the global population after surgery has been reported to vary widely from 64 to 93%. This study aims to determine various clinical, biochemical, radiological and histological factors that correlate with persistence and recurrence in patients with CD. This study also aims to understand the clinicopathological significance of EGFR-MAPK, NF-kB and SHH pathway activation and to study the protein expression levels of activation markers of these pathways viz. c-Fos , c-Jun, GLI-1 , pMEK, NR4A1 and p44 in functioning corticotroph pituitary adenomas. - Source: PubMed
Publication date: 2024/05/09
Sadhwani NidhishaBora Santanu KumarDeepa SKatiyar VaridhRaheja AmolGarg AjaySuri VaishaliTandon NikhilSharma Mehar ChandKhadgawat RajeshSuri Ashish - Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental cardiac remodeling and may lead to heart failure. Whether catecholamine treatment in absence of heart failure causes persistent cardiac injury, is uncertain. In this experimental study, we assessed the course of cardiac remodeling and recovery during and after prolonged catecholamine treatment and investigated the molecular mechanisms involved. - Source: PubMed
Publication date: 2024/05/11
Bode ChristinePreissl SebastianHein LutzLother Achim