Bos taurus,Bovine,Tetraspanin-5,TSPAN5,Tspan-5
- Known as:
- Bos taurus,Bovine,Tetraspanin-5,TSPAN5,Tspan-5
- Catalog number:
- EIAAB44279
- Category:
- -
- Supplier:
- EIAab
- Gene target:
- Bos taurus Bovine Tetraspanin-5 TSPAN5 Tspan-5
Ask about this productRelated genes to: Bos taurus,Bovine,Tetraspanin-5,TSPAN5,Tspan-5
- Gene:
- TSPAN5 NIH gene
- Name:
- tetraspanin 5
- Previous symbol:
- TM4SF9
- Synonyms:
- Tspan-5, NET-4
- Chromosome:
- 4q23
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-21
- Date modifiied:
- 2016-10-05
Related products to: Bos taurus,Bovine,Tetraspanin-5,TSPAN5,Tspan-5
(Ala11·22·28)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (Ala11·22·28)_Aviptadil SumFormula C139H231N43O39S(Ala11·22·28)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (Ala11·22·28)_Aviptadil SumFormula C139H231N43O39S(Ala13)-Apelin-13 (human, bovine, mouse, rat) 98% C63H107N23O16S CAS: 568565-11-7(Ala13)_Apelin_13 (human, bovine, mouse, rat) Salt Trifluoroacetate Binding _ Synonym SumFormula C63H107N23O16S(Ala13)_Apelin_13 (human, bovine, mouse, rat) Salt Trifluoroacetate Binding _ Synonym SumFormula C63H107N23O16S(Ala96)-Myelin Basic Protein (87-99) (human, bovine, rat) 98% C70H110N20O17 CAS:(Ala96)_Myelin Basic Protein (87_99) (human, bovine, rat) Salt _ Binding _ Synonym SumFormula C72H112N20O17(Ala96)_Myelin Basic Protein (87_99) (human, bovine, rat) Salt _ Binding _ Synonym SumFormula C72H112N20O17(b_Asp3)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (b_Asp3)_Aviptadil SumFormula C147H238N44O42S(b_Asp3)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (b_Asp3)_Aviptadil SumFormula C147H238N44O42S(D-Ala2,Met5)-β-Casomorphin (1-5) amide (bovine) 98% C31H42N6O6S CAS:(D-Lys16)-ACTH (1-24) (human, bovine, rat)
(D-Lys16)-Tetracosactide 98% C136H210N40O31S CAS: 494750-52-6(D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat(D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat(D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat Related articles to: Bos taurus,Bovine,Tetraspanin-5,TSPAN5,Tspan-5
- Kawasaki disease (KD) is a condition characterized by acute multi-system vasculitis and high fever in infants and children. Intravenous immunoglobulin (IVIG) is the established therapeutic approach of KD,foralleviating inflammation and mitigate the risk of arterial wall dilation and the development of coronary artery aneurysms (CAA). But almost 20% of the patients developed resistance to IVIG and displayed persistent fever after standard primary treatment. , belonging to the Tetraspanin family, has been demonstrated to modulate innate immunity in a range of human diseases. It accomplishes this by engaging with integrins and actively participating in the process of infection recognition. However, its relevance to susceptibility and IVIG therapy response of KD was unexposed. In the present study, our Integrative analysis of KD transcriptomic data and GTEx data revealed that the eQTL rs12504972 might modify the downregulation of in KD patients. Moreover, our findings suggest a potential association between /rs12504972 and an elevated susceptibility as well as IVIG resistance among patients with Kawasaki disease in southern China. The results provided a new insight that triggered KD susceptibility and resistance of IVIG therapy on the genomic level. - Source: PubMed
Publication date: 2024/03/12
Chen KainingLuo XilianZhou HuazhongFu LanyanLu ZhaojinWang ChenluLin YuelingYu HongyanXu YufenPi LeiChe DiWang ZhoupingGu Xiaoqiong - - Source: PubMed
Publication date: 2024/02/18
Wei ShiyuanGao TianyangWu YihuaWang GuimingChen YaoTao XinliLiang YingqiuZhou ZijunSun LiyanLiu MinyinLi HaiyanBao Yanjing - Digestive system malignancies, including cancers of the esophagus, pancreas, stomach, liver, and colorectum, are the leading causes of cancer-related deaths worldwide due to their high morbidity and poor prognosis. The lack of effective early diagnosis methods is a significant factor contributing to the poor prognosis for these malignancies. Tetraspanins (Tspans) are a superfamily of 4-transmembrane proteins (TM4SF), classified as low-molecular-weight glycoproteins, with 33 Tspan family members identified in humans to date. They interact with other membrane proteins or TM4SF members to form a functional platform on the cytoplasmic membrane called Tspan-enriched microdomain and serve multiple functions including cell adhesion, migration, propagation and signal transduction. In this review, we summarize the various roles of Tspans in the progression of digestive system tumors and the underlying molecular mechanisms in recent years. Generally, the expression of CD9, CD151, Tspan1, Tspan5, Tspan8, Tspan12, Tspan15, and Tspan31 are upregulated, facilitating the migration and invasion of digestive system cancer cells. Conversely, Tspan7, CD82, CD63, Tspan7, and Tspan9 are downregulated, suppressing digestive system tumor cell metastasis. Furthermore, the connection between Tspans and the metastasis of malignant bone tumors is reviewed. We also summarize the potential role of Tspans as novel immunotherapy targets and as an approach to overcome drug resistance. Finally, we discuss the potential clinical value and therapeutic targets of Tspans in the treatments of digestive system malignancies and provide some guidance for future research. - Source: PubMed
Publication date: 2024/02/08
Shao ShijieBu ZhenXiang JinghuaLiu JiachenTan RuiSun HanHu YuanwenWang Yimin - Placental trophoblastic cells play important roles in placental development and fetal health. However, the mechanism of trophoblastic cell fusion is still not entirely clear. The level of Tspan5 in the embryo culture medium was detected using enzyme-linked immunosorbent assay (ELISA). Fusion of BeWo cells was observed by immunofluorescence. Cell fusion-related factors and EMT-related factors were identified by qRT-PCR and western blotting. Notch protein repressor DAPT was used to verify the role of Tspan5 in BeWo cells. The expression of Tspan5 was significantly increased in embryo culture medium. The fusion of BeWo cells was observed after treatment with forskolin (FSK). Cell fusion-related factors (i.e. β-hCG and syncytin 1/2) and Tspan5 were significantly increased after FSK treatment. In addition, FSK treatment promoted EMT-related protein expression in BeWo cells. Knockdown of Tspan5 inhibited cell fusion and EMT-related protein levels. Notch-1 and Jagged-1 protein levels were significantly upregulated, and the EMT process was activated by overexpression of Tspan5 in FSK-treated BeWo cells. Interestingly, blocking the Notch pathway by the repressor DAPT had the opposite results. These results indicated that Tspan5 could promote the EMT process by activating the Notch pathway, thereby causing cell fusion. These findings contribute to a better understanding of trophoblast cell syncytialization and embryonic development. Tspan5 may be used as a therapeutic target for normal placental development. - Source: PubMed
Publication date: 2023/07/24
Tang Hai-YuLin MeiLiang Yong-QianWang Jin-HuaYi Hong-GanYang Man - Mechanism of Chlamydia trachomatis causing tubal ectopic pregnancy (EP) is not well understood. Tetraspanins (tspans), activin-A, and inhibin-A might play a role in the development of pathological conditions leading to EP. The study aimed to elucidate the expression of tspans, activin-A, and inhibin-A with a role of associated cytokines in C. trachomatis-associated EP and analyze interacting partners of DEGs, with an expression of a few important interacting genes. Fallopian tissue and serum were collected from 100 EP (Group I) and 100 controls (Group II) from SJH, New Delhi, India. Detection of C. trachomatis was done by polymerase chain reaction (PCR) and IgG antibodies were detected by enzyme-linked immunosorbent assay. Expression of tspans, activin-A, inhibin-A, and cytokines was analyzed by real time (RT)-PCR and their interacting genes were assessed by STRING. Expression of few disease-associated interacting genes was studied by RT-PCR. A total of 29% (Group I) were C. trachomatis positive. Tspans and activin-A were significantly upregulated, while inhibin-A was significantly downregulated in Group Ia. ITGA1, TLR-2, ITGB2, and Smad-3 were a few interacting genes. Expression of ITGA1, TLR-2, and Smad-3 was significantly upregulated in C. trachomatis-positive EP. Results suggested dysregulated tspans, activin-A, and inhibin-A might play a role in C. trachomatis-infected tubal EP. - Source: PubMed
Pant ShipraBhati TanuDimri AsthaArora RenuSiraj FouziaRaisuddin SheikhRastogi Sangita