Antigens AKR1B10, 1-316 aa, Human, Recombinant, E.coli
- Known as:
- Antigens AKR1B10, 1-316 aa, Human, Recombinant, E.coli
- Catalog number:
- 01-2078
- Product Quantity:
- 20
- Category:
- -
- Supplier:
- ARP
- Gene target:
- Antigens AKR1B10 1-316 Human Recombinant .coli
Related genes to: Antigens AKR1B10, 1-316 aa, Human, Recombinant, E.coli
- Gene:
- AKR1B10 NIH gene
- Name:
- aldo-keto reductase family 1 member B10
- Previous symbol:
- AKR1B11
- Synonyms:
- AKR1B12, ARL-1, HIS, ARL1, HSI, ALDRLn
- Chromosome:
- 7q33
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-24
- Date modifiied:
- 2016-06-03
- Gene:
- BEST3 NIH gene
- Name:
- bestrophin 3
- Previous symbol:
- VMD2L3
- Synonyms:
- MGC40411, MGC13168
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-03
- Date modifiied:
- 2015-01-28
- Gene:
- CNOT10 NIH gene
- Name:
- CCR4-NOT transcription complex subunit 10
- Previous symbol:
- -
- Synonyms:
- FLJ12890, FLJ13165
- Chromosome:
- 3p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-11
- Date modifiied:
- 2016-10-05
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- INTS8 NIH gene
- Name:
- integrator complex subunit 8
- Previous symbol:
- C8orf52
- Synonyms:
- FLJ20530, INT8, MGC131633
- Chromosome:
- 8q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-30
- Date modifiied:
- 2014-11-19
Related products to: Antigens AKR1B10, 1-316 aa, Human, Recombinant, E.coli
Related articles to: Antigens AKR1B10, 1-316 aa, Human, Recombinant, E.coli
- Evidence suggests that hepatocyte mitochondrial dysfunction leads to abnormal lipid metabolism, redox imbalance, and programmed cell death, driving the onset and progression of non-alcoholic steatohepatitis (NASH). Identifying hub mitochondrial genes linked to NASH may unveil potential therapeutic targets. - Source: PubMed
Publication date: 2024/05/08
Dai LongfeiJiang RenaoZhan ZhichengZhang LiangliangQian YuyangXu XinjianYang WenqiZhang Zhen - Pancreatic ductal adenocarcinoma (PDAC), is characteristic by a heterogeneous tumor microenvironment and gene mutations, conveys a dismal prognosis and low response to chemotherapy and immunotherapy. Here, we found that checkpoint suppressor 1 (CHES1) served as a tumor repressor in PDAC and was associated with patient prognosis. Functional experiments indicated that CHES1 suppressed the proliferation and invasion of PDAC by modulating cellular senescence. To further identify the downstream factor of CHES1 in PDAC, label-free quantitative proteomics analysis was conducted, which showed that the oncogenic Aldo-keto reductase 1B10 (AKR1B10) was transcriptionally repressed by CHES1 in PDAC. And AKR1B10 facilitated the malignant activity and repressed senescent phenotype of PDAC cells. Moreover, pharmaceutical inhibition of AKR1B10 with Oleanolic acid (OA) significantly induced tumor regression and sensitized PDAC cells to gemcitabine, and this combined therapy did not cause obvious side effects. Rescued experiments revealed that CHES1 regulated the tumorigenesis and gemcitabine sensitivity through AKR1B10-mediated senescence in PDAC. In summary, this study revealed that the CHES1/AKR1B10 axis modulated the progression and cellular senescence in PDAC, which might provide revenues for drug-targeting and senescence-inducing therapies for PDAC. - Source: PubMed
Publication date: 2024/05/06
Kong DeminWu YingyingTong BinghuaLiang YonghuiXu FuyiChi XiaodongNi LeiTian GengZhang GuilongXu Zhaowei - Oral squamous cell carcinoma (OSCC) remains a rampant oral cavity neoplasm with high degree of aggressiveness. Aldo-keto reductase 1B10 (AKR1B10) that is an oxidoreductase dependent on nicotinamide adenine dinucleotide phosphate (NADPH) has been introduced to possess prognostic potential in OSCC. The present work was focused on specifying the involvement of AKR1B10 in the process of OSCC and its latent functional mechanism. - Source: PubMed
Publication date: 2024/04/26
Cai YeLi HuilingXie DiyaZhu Yanan - Long noncoding RNAs (lncRNAs) have been shown to be related to the occurrence and development of a variety of cancers including hepatocellular carcinoma (HCC). However, a large number of potential HCC-related lncRNAs remain undiscovered and are yet to be fully understood. - Source: PubMed
Publication date: 2024/04/25
Tan ChaoZeng XiGuo XuefengMo MeileMa XiaoyunLiu BihuLiu ShunZeng XiaoyunHuang DongpingQiu Xiaoqiang - CESC is the second most commonly diagnosed gynecological malignancy. Given the pivotal involvement of metabolism-related genes (MRGs) in the etiology of multiple tumors, our investigation aims to devise a prognostic risk signature rooted in cancer stemness and metabolism. - Source: PubMed
Publication date: 2024/04/23
Wang YaokaiHan YuanyuanJin LiangziJi LuluLiu YanxiangLin MinZhou SitongYang Ronghua