ANGI_PIG RNase 5 ELISA tesk kit
- Known as:
- ANGI_PIG RNase 5 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen0108
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- EIAab
- Gene target:
- ANGI_PIG RNase 5 ELISA tesk kit
Ask about this productRelated genes to: ANGI_PIG RNase 5 ELISA tesk kit
- Gene:
- RNASE6 NIH gene
- Name:
- ribonuclease A family member k6
- Previous symbol:
- RNS6
- Synonyms:
- RAD1, RNaseK6
- Chromosome:
- 14q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-01-08
- Date modifiied:
- 2016-10-05
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- Immunological regimens are an important area of research for treating multiple myeloma (MM). Plasma cells play a crucial role in immunotherapy. - Source: PubMed
Publication date: 2024/03/09
Long XinyiLi FangfangTang SishiLiu JingFu YunfengFeng Yanhui - Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to the inflammatory response in the nervous system, typically resulting from damage to neural tissue. Immune-related processes have been identified in NTDs, however, the detailed relationship and underlying mechanisms between neuroinflammation and NTDs remain largely unclear. In this study, we utilized integrated multi-omics analysis to explore the role of neuroinflammation in NTDs and identify potential prenatal diagnostic markers using a murine model. - Source: PubMed
Publication date: 2024/03/09
Wang WenshuangJi YanhongDong ZhexuLiu ZheranChen ShuangDai LeiSu XiaolanJiang QingyuanDeng Hongxin - The tumor immune microenvironment can influence the prognosis and treatment response to immunotherapy. We aimed to develop a non-invasive radiomic signature in high-grade glioma (HGG) to predict the absolute density of tumor-associated macrophages (TAMs), the preponderant immune cells in the microenvironment of HGG. We also aimed to evaluate the association between the signature, and tumor immune phenotype as well as response to immunotherapy. - Source: PubMed
Publication date: 2024/01/31
Chen DiZhang RuiHuang XiaomingJi ChunxiaXia WeiQi YingYang XinyuLin LishuangWang JingCheng HaixiaTang WeijunYu JinhuaHoon Dave S BZhang JunGao XinYao Yu - Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by fat accumulation in the liver. MASLD encompasses both steatosis and MASH. Since MASH can lead to cirrhosis and liver cancer, steatosis and MASH must be distinguished during patient treatment. Here, we investigate the genomes, epigenomes, and transcriptomes of MASLD patients to identify signature gene set for more accurate tracking of MASLD progression. - Source: PubMed
Publication date: 2024/01/26
Oh SuminBaek Yang-HyunJung SungjuYoon SuminKang ByeonggeunHan Su-HyangPark GaeulKo Je YeongHan Sang-YoungJeong Jin-SookCho Jin-HanRoh Young-HoonLee Sung-WookChoi Gi-BokLee Yong SunKim WonSeong Rho HyunPark Jong HoonLee Yeon-SuYoo Kyung Hyun - Human Ribonuclease (RNase) 6 is a monocyte and macrophage-derived protein with potent antimicrobial activity toward uropathogenic bacteria. The gene is heterogeneous in humans due to the presence of single nucleotide polymorphisms (SNPs). rs1045922 is the most common non-synonymous SNP, resulting in a G to A substitution that determines an arginine (R) to glutamine (Q) transversion at position 66 in the protein sequence. By structural analysis we observed that R66Q substitution significantly reduces the positive electrostatic charge at the protein surface. Here, we generated both recombinant RNase 6-R66 and -Q66 protein variants and determined their antimicrobial activity toward uropathogenic (UPEC), the most common cause of UTI. We found that the R66 variant, encoded by the major SNP rs1045922 allele, exhibited superior bactericidal activity in comparison to the Q66 variant. The higher bactericidal activity of R66 variant correlated with an increase in the protein lipopolysaccharide binding and bacterial agglutination abilities, while retaining the same enzymatic efficiency. These findings encourage further work to evaluate SNP distribution and its impact in UTI susceptibility. - Source: PubMed
Publication date: 2024/01/03
Anguita RaulPrats-Ejarque GuillemMoussaoui MohammedBecknell BrianBoix Ester