1.5ml screw cap tube, non-skirted base, amber, non-sterile
- Known as:
- 1.5ml screw cap tube, non-skirted base, amber, non-sterile
- Catalog number:
- TN5115A
- Product Quantity:
- 10 cs
- Category:
- -
- Supplier:
- ACT
- Gene target:
- 1.5ml screw cap tube non-skirted base amber non-sterile
Related genes to: 1.5ml screw cap tube, non-skirted base, amber, non-sterile
- Gene:
- TSC2 NIH gene
- Name:
- TSC complex subunit 2
- Previous symbol:
- TSC4
- Synonyms:
- tuberin, LAM, PPP1R160
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: 1.5ml screw cap tube, non-skirted base, amber, non-sterile
Related articles to: 1.5ml screw cap tube, non-skirted base, amber, non-sterile
- Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While ethnic differences in driver gene mutations have been documented, the South American population remains understudied at the genomic level, despite facing a rising burden of CRC. We analyzed tumors of 40 Chilean CRC patients (Chp) using next-generation sequencing and compared them to data from mainly Caucasian cohorts (TCGA and MSK-IMPACT). We identified 388 mutations in 96 out of 135 genes, with (45%), (30%), (22.5%), (20%), and (20%) being the most frequently mutated. mutations were associated with right colon cancer (44.44% in RCRC vs. 6.45% in LCRC, -value = 0.016), and overall frequency was higher compared to TCGA (-value = 1.847 × 10) and MSK-IMPACT cohorts (-value = 3.062 × 10). Limited sample size restricts definitive conclusions, but our data suggest potential differences in driver mutations for Chilean patients, being that the RTK-RAS oncogenic pathway is less affected and the PI3K pathway is more altered in Chp compared to TCGA (45% vs. 25.56%, respectively). The prevalence of actionable pathways and driver mutations can guide therapeutic choices, but can also impact treatment effectiveness. Thus, these findings warrant further investigation in larger Chilean cohorts to confirm these initial observations. Understanding population-specific driver mutations can guide the development of precision medicine programs for CRC patients. - Source: PubMed
Publication date: 2024/04/25
Tapia-Valladares CamiloValenzuela GuillermoGonzález EvelinMaureira IgnacioToro JessicaFreire MatíasSepúlveda-Hermosilla GonzaloAmpuero DiegoBlanco AlejandroGallegos IvánMorales FernandaErices José IBarajas OlgaAhumada MónicaContreras Héctor RGonzález JaimeArmisén RicardoMarcelain Katherine - Tuberous sclerosis complex (TSC) is a genetic disorder caused by a or gene variation characterized by widespread hamartomas in organs such as the skin, brain, heart, lungs, liver, and kidneys. - Source: PubMed
Publication date: 2024/02/16
Lai YujieMa YuanyeLuo BiaoLong Yan - - Source: PubMed
Publication date: 2024/04/28
Fu JiahuiLiang PeiliZheng YingchunXu CailingXiong FuYang Fang - We recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 36 healthy recreationally active young males (age: 24.2±4.1 y) ingested either: 1) 0.36 g ∙ kg bodyweight of the ketone monoester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (KET), 2) 10 g whey protein (PRO), or 3) the combination of both (KET+PRO). Muscle biopsies were obtained in the overnight postabsorptive state (basal conditions), and at 120- and 300-minutes in the postprandial period for immunofluorescence assessment of protein translocation and co-localization of mTOR-related signaling molecules. All treatments resulted in a significant (Interaction: <0.0001) decrease in tuberous sclerosis complex 2 (TSC2)-Ras homolog enriched in brain (Rheb) co-localization at 120-minutes vs. basal; however, the decrease was sustained at 300-minutes vs. basal (<0.0001) only in KET+PRO. PRO and KET+PRO increased (Interaction: <0.0001) mTOR-Rheb co-localization at 120-minutes vs. basal; however, KET+PRO resulted in a sustained increase in mTOR-Rheb co-localization at 300-minutes that was greater than KET and PRO. Treatment intake increased mTOR-wheat germ agglutinin (WGA) co-localization at 120- and 300-minutes (Time: =0.0031), suggesting translocation toward the fiber periphery. These findings demonstrate that ketone monoester intake can influence the spatial mechanisms involved in the regulation of mTORC1 in human skeletal muscle. - Source: PubMed
Publication date: 2024/04/29
Hannaian Sarkis JLov JamieCheng-Boivin ZacharieAbou Sawan SidneyHodson NathanGentil Benoit JMorais José AChurchward-Venne Tyler A - Rare sarcomas present significant treatment challenges compared to more prevalent soft tissue sarcomas due to limited treatment options and a poor understanding of their biology. This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models-including patient-derived xenograft (PDX), 3D, and monolayer primary cultures-we successfully replicated crucial molecular traits observed in the patient's tumor, such as smooth muscle actin and CD99 expression, along with specific mutations in genes like and . These models are helpful in assessing the potential for an in-depth exploration of this tumor's biology. This comprehensive approach holds promise in identifying potential therapeutic avenues for managing this exceedingly rare soft tissue sarcoma. - Source: PubMed
Publication date: 2024/03/28
Sousa Ariane Cavalcante Dos SantosFernandes Bruno Leonardo Nascimento Correada Silva Jeronimo Paulo AssisStevanato Filho Paulo RobertoCoimbra Luiza Bitencourt de Carvalho Tercide Oliveira Beserra AdrianoAlvarenga Ana LuizaMaida GiovannaGuimaraes Camila TokumotoNakamuta Ingrid MartinezMarchi Fabio AlbuquerqueAlves CamilaLichtenfels Martinade Farias Caroline BrunettoKupper Bruna Elisa CatinCosta Felipe D'Almeidade Mello Celso Abdon LopesCarraro Dirce MariaTorrezan Giovana TardinLopes AdemarDos Santos Tiago Goss