FLNA
- Known as:
- FLNA
- Catalog number:
- AP14559PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- FLNA
Related genes to: FLNA
- Gene:
- FLNA NIH gene
- Name:
- filamin A
- Previous symbol:
- FLN1, FLN, OPD2, OPD1
- Synonyms:
- ABP-280
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-18
- Date modifiied:
- 2019-04-23
Related products to: FLNA
Anserine Filamin A, Alpha Elisa Kit (FLNa)Anserine anti - Filamin A, Alpha Elisa Kit (FLNa)anti-FLNA FMD (4E10-1B2)anti-FLNA FMD (4E10-1B2) type: Primary antibodies host: MouseAnti-FLNA (4E10-1B2), Mouse Monoclonal to FLNA, Isotype IgG1, Host Mouseanti-FLNA / FMDanti-FLNA / FMD (4E10-1B2)Bovine Filamin A, Alpha ELISA , FLNaBovine Filamin A, Alpha ELISA , FLNaBovine Filamin A, Alpha Elisa Kit (FLNa)CAMK2G & FLNA Protein Protein Interaction Antibody PairCAMK2G & FLNA Protein Protein Interaction Antibody Pair pairsCanine Filamin A, Alpha ELISA , FLNaCanine Filamin A, Alpha ELISA , FLNaCanine Filamin A, Alpha Elisa Kit (FLNa) Related articles to: FLNA
- Extracellular vesicles (EVs) are promising to provide chemical predictors toward clinical diagnosis and prognosis. However, the isolation of high-purity EVs from complex bodily fluids is a little complex. To address this issue, a choline phosphate (CP)-functionalized adsorbent, designated as SCF@CP-Et, was prepared by grafting 2-(isopropylacryloyloxy)ethyl choline phosphate (CP-Et) from the surface of sulphydryl cotton fiber (SCF) via thiol-ene click polymerization. The SCF@CP-Et indicates a high-efficiency EV enrichment capability arising from the multivalent coordination interaction between the CP groups and phosphatidylcholine (PC) on EV membrane surface, meanwhile possesses an excellent anti-protein adsorption performance derived from the abundant hydroxyl groups of cotton fiber and zwitterionic property of CP-Et. Besides, this cotton fiber is easily assembled into a cotton fiber-in-syringe solid-phase extraction (SPE) device. This device shows simple and convenient operation during the isolation of EVs from various samples, including cell culture medium, plasma and urine. Meanwhile, the released EVs can maintain their biological activity. Taking advantage of these properties, this method was employed to isolate EVs in the plasma of colorectal cancer (CRC) patients and healthy donors, and 69 up-regulated and 18 down-regulated proteins are identified by proteomics analysis. Most of these up-regulated proteins, such as TLNA, FLNA, ITGB3 and MYH9, are associated with the progression of CRC, demonstrating the potential of this carbon fiber-based SPE method in the EV-based early diagnosis of diseases. - Source: PubMed
Publication date: 2026/04/17
Chen MengxiTang YingyingJiang ZiyiZhang JingZhang HaiyangWei Yinmao - X-linked intellectual disability (XLID) is a well-recognized group of neurodevelopmental disorders, with pathogenic variants in X-chromosomal genes accounting for approximately 16% of intellectual disability cases in males. Clinical expression in females is variable and depends on patterns of X-chromosome inactivation. We describe three affected individuals from a single family with XLID caused by a confirmed duplication of the Xq28 region, including the genes , and . Two male siblings presented with severe phenotypes, including profound intellectual disability, severe speech impairment, behavioral issues, facial dysmorphism, spastic cerebral palsy, epilepsy, and cutaneous abnormalities. Their mother showed mild intellectual disability and skin manifestations. Family history suggested additional affected male relatives with a similar or even more severe clinical presentation. The duplication of multiple dosage-sensitive genes within the Xq28 region likely explains the multisystem involvement and the marked phenotypic variability observed between male and female family members. This report highlights the importance of considering Xq28 duplication, the most common X-linked copy number variation associated with intellectual disability, in the differential diagnosis of families with X-linked intellectual disability, especially if it is accompanied by additional neurological impairment. - Source: PubMed
Publication date: 2026/04/22
Gaberova KaterinaPacheva Iliyana HristovaYordanova RalitsaTodorov TihomirTodorova AlbenaGrozdanova LiliyanaPanova MargaritaGeorgieva MariyanaIvanov Ivan Stefanov - Periventricular nodular heterotopia (PVNH) is a malformation of cortical development (MCD) mainly caused by aberrant neuronal migration, and a group of diseases sharing similar pathological manifestations, including the presence of nodular clusters of abnormal neurons in the subependymal region. PVNH is one of major causes that result in genetic epilepsy. Seizures can strike as early as a few days after birth but are more common at 10-20 years old, and among them, generalized tonic-clonic seizures are commonly observed. PVNH is a highly genetically heterogeneous disease associated with various rare single gene variants. However, despite the fact that the FLNA gene is identified to be closely correlated with the presence of PVNH, mutations in other genes were understudied and have not attracted as much attention due to the relatively low morbidity of PVNH. In consequence, an updated spectrum of PVNH-associated risk genes with potentially pathogenic changes that lead to PVNH in human patients is urgently needed. The risk genes that have already been clinically reported for PVNH are summarized here chronologically according to when the first patient was reported, and clinical manifestations of patients with each of these genes are described. Human cerebral organoids as well as animal models are subsequently discussed in this review to reveal alterations in risk gene products and the pathogenesis of PVNH. - Source: PubMed
Publication date: 2026/05/02
Song JianpingSun XiaoqinZhang Chunqing - Cognitive impairment (CI) is a prevalent and debilitating non-motor symptom in Parkinson's disease (PD), yet reliable early diagnostic biomarkers are lacking. This study aimed to identify serum biomarkers associated with PD-CI and investigate the synergistic contributions of lipid metabolism and inflammatory signaling. - Source: PubMed
Publication date: 2026/04/15
Su MingyuYang TianshuFan XinruiQiang XiyuLiao ZihanGu HengGao LinyunChen RuiTang ChuanxiMu Chunyan - - Source: PubMed
Chaud German J