CD95 _ FAS pTyr232
- Known as:
- CD95 _ Fas Cell Surface Death Receptor pTyr232
- Catalog number:
- AP12873PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS pTyr232
Related genes to: CD95 _ FAS pTyr232
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS pTyr232
Related articles to: CD95 _ FAS pTyr232
- Fatty acid synthase (FAS), the rate-limiting enzyme of de novo lipogenesis, is now recognized as a multifunctional regulator of cardiovascular homeostasis; its roles extend beyond simple FA biosynthesis to encompass calcium signaling, cholesterol trafficking, and inflammatory modulation. This review synthesizes current understanding of FAS molecular biology, tissue-specific expression, and pathophysiological contributions to cardiovascular disease. Circulating FAS (cFAS) associates with lipoproteins and promotes macrophage foam cell formation independently of low-density lipoprotein cholesterol concentration, establishing a novel atherogenic mechanism. cFAS is primarily hepatic in origin and is released under conditions of enhanced de novo lipogenesis and insulin resistance. Adipose tissue may also contribute through extrusion of FAS. In macrophages, Fasn deletion enhances cholesterol efflux through liver X receptor alpha induction and ATP-binding cassette transporter A1 upregulation, reducing atherosclerosis by 20-40% in preclinical models without affecting serum lipids. Vascular smooth muscle cells upregulate FAS during phenotypic switching, facilitating transformation into foam cells within plaques. Clinical studies have established cFAS as a diagnostic biomarker for peripheral arterial disease, with higher concentrations present in affected individuals; elevated cFAS may also discriminate more severe disease. Despite its pathogenic roles in atherosclerosis, cardiac FAS serves essential stress-adaptive functions through calcium/calmodulin-dependent protein kinase II regulation, as cardiac-specific Fasn knockout mice exhibit profound stress intolerance and accelerated aging-related cardiac dysfunction, demonstrating that FAS-mediated de novo lipogenesis is indispensable for myocardial stress responses. This observation necessitates tissue-specific therapeutic approaches. Pharmacological FAS inhibitors, including TVB-2640 (denifanstat), demonstrate acceptable safety profiles in clinical trials and reduce hepatic de novo lipogenesis by 50-70%, while platensimycin reduces atherosclerotic burden in preclinical models. These findings position FAS as both a mechanistic driver and promising therapeutic target for cardiovascular disease. However, the divergent consequences of FAS modulation across tissues underscore the need for targeted delivery strategies that suppress pathological lipogenesis while preserving essential cardiac functions. - Source: PubMed
Publication date: 2026/09/12
Ibrahim DinaZaghloul Mohamed SKoklu BeraElahi AbdullahJanuzzi James LBonaca Marc PZayed Mohamed A - This retrospective cross-sectional study examined whether the Functional Acuity Score (FAS), an administrative impairment measure calculated from routine visual acuity data, was associated with reading performance in individuals undergoing formal visual disability evaluation. Thirty-one participants applying for visual disability certification at a tertiary eye hospital in Japan underwent Goldmann perimetry and MNREAD-J testing within 12 months. FAS, the Functional Field Score (FFS), and the Functional Vision Score (FVS) were calculated according to the AMA Guides. Their associations with reading outcomes, including critical print size (CPS) and the reading accessibility index (ACC), were assessed using correlation and multivariable regression analyses. FAS was strongly correlated with better-eye visual acuity (rho = 0.963) and showed the strongest associations with reading performance among the impairment measures. It was associated with CPS (rho = -0.82) and ACC (rho = 0.69) and remained associated with both outcomes in adjusted regression models, with R2 values of up to 0.76 after FAS was included. Field-based measures showed weak or inconsistent associations with reading parameters. The cohort consisted mainly of patients with glaucoma and other non-macular conditions (27/31, 87.1%). In this predominantly non-macular disability-evaluation cohort, FAS may provide an estimate of resolution-dependent reading performance when direct assessment is not available. However, only 4 of 31 participants had macular disease, and whether these findings apply to patients with macular pathology remains unclear. - Source: PubMed
Publication date: 2026/09/11
Tsuruoka MiekoInoue Kenji - Periodontal ligament (PDL) cells play a central role in periodontal tissue regeneration. We previously established induced pluripotent stem cell-derived PDL-like cells (iPS-PDL) as a potential alternative cell source for regenerative therapy. However, the properties and biological functions of extracellular vesicles (EVs) released by iPS-PDL remain unknown. Characterizing these EVs may facilitate the development of cell-free approaches for periodontal regeneration. - Source: PubMed
Publication date: 2026/08/27
Taniguchi YurieIwasaki KengoYamamoto TomofumiJo Jun-IchiroIshikawa HirokiMomota YoshihiroHashimoto Yoshiya - Insulin resistance has been independently associated with cardiac diseases. Free fatty acids (FFAs) are known to induce cardiac insulin resistance via low-grade inflammation. Therefore, lowering FFA levels may improve cardiac insulin resistance. This study investigated the effects of a combination of green tea and decaffeinated light-roasted green coffee extract on free fatty acid-induced cardiac insulin resistance by modulating the adiponectin/FAS pathways. - Source: PubMed
Publication date: 2026/07/03
Lukitasari MifetikaRohman Mohammad SaifurNugroho Dwi AdiNur Kholis MukhamadWahyuni Nila AisyahWidodo Nashi - The genetic basis of multifunctional traits shaped by both natural and sexual selection remains poorly understood. In insects, cuticular hydrocarbons (CHCs) are an excellent example of such traits, providing protection against different micro-climatic conditions while simultaneously encoding cues predominantly used in sexual signaling. The fatty acid synthase (fas) gene family has been implied as an important cornerstone in initiating and maintaining CHC functionality, whereas their exact biosynthetic and regulatory mechanisms have remained largely elusive. Here, we characterize a single fatty acid synthase gene (fas3) impacting the main CHC functions in the parasitoid wasp Nasonia vitripennis. Knockdown of fas3 significantly decreases wasp survival under desiccation stress while also completely depleting sexual attractiveness of female wasps, where this trait naturally functions as sex pheromone. Further transcriptomic analyses reveal that fas3 is co-expressed with other fas and CHC-associated genes, as well as key biosynthetic pathway hubs. We also identify striking sex-specific expression differences in fas3 across different developmental stages, suggesting divergent functional roles of this gene in males and females. These findings largely advance our knowledge on the multifunctionality of fas genes in governing survival and sexual signaling mechanisms and underscore their relevance for future studies on metabolomics, adaptation, and sexual communication. - Source: PubMed
Publication date: 2026/09/11
Sun WeizhaoClinder ClaraErrbii MohammedSchrader LukasGadau JuergenBuellesbach Jan