GLI1 (aa 805_820)
- Known as:
- GLI1 (aa 805_820)
- Catalog number:
- AP09019PU-N
- Product Quantity:
- 50 µl
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GLI1 ( 805_820)
Related genes to: GLI1 (aa 805_820)
- Gene:
- GLI1 NIH gene
- Name:
- GLI family zinc finger 1
- Previous symbol:
- GLI
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-01-15
Related products to: GLI1 (aa 805_820)
Related articles to: GLI1 (aa 805_820)
- - Source: PubMed
Publication date: 2026/06/04
Wolfram ChristopherMcAlpine Cameron S - To investigate the role and epigenetic mechanism of methyltransferase 14 (METTL14)-mediated N6-adenylate methylation (m6A) modification of long non-coding RNAs (lncRNAs) in the pathogenesis of periodontitis. - Source: PubMed
Publication date: 2026/06/17
Du JuanCheng Zi'angZhang YuCong YaqiGuo DonghuaZhou YiHuang Jing - Diagnosing low-grade spindle cell lesions of the skin can be challenging. In particular, distinguishing among fibroblastic, myofibroblastic, and smooth muscle or pericytic proliferations may be difficult during a routine histologic examination. This article provides an update on recent developments in superficial mesenchymal tumors exhibiting smooth muscle and pericytic differentiation. We focus on the characterization of clinicopathological features, differential diagnosis, and recurrent molecular alterations. Additionally, we address superficial leiomyosarcomas, which are now classified as atypical intradermal smooth muscle neoplasms due to their low risk of aggressive behavior. The article also discusses Epstein-Barr virus-associated smooth muscle tumors. - Source: PubMed
Publication date: 2026/06/16
Machado IsidroParafioriti AntoninaArmiraglio ElisabettaPadilla-Esquivel Jaime JoséSuarez Natalia RojoTraves VíctorLlombart Beatriz - Abnormal activation of Hedgehog signaling is involved in renal fibrogenesis, a key process in chronic kidney disease (CKD) progression. However, the isoform-specific roles of Gli transcription factors remain unclear. This study aimed to elucidate the contribution of Gli2 to renal fibrosis. Multiple murine models of renal fibrosis-unilateral ureteral obstruction, ischemia-reperfusion injury, and aristolochic acid nephropathy-were employed, alongside human CKD specimens. In vitro assays, including genetic silencing, overexpression, co-immunoprecipitation, immunofluorescence, promoter analysis, F-actin staining, and TGF-β/SB431542 intervention assays were used to evaluate Gli2 function and its interaction with FoxM1. This study identifies Gli2, but not Gli1 or Gli3, as the primary Hedgehog signaling mediator in fibrotic kidneys, showing its activation in both epithelial and interstitial compartments. TGF-β-induced Gli2 activation promoted fibrogenesis via tubular epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast differentiation (FMD), and cytoskeletal remodeling. FoxM1 is a potential dowgnstream candidate transcriptionally regulated by Gli2, with two conserved Gli-binding sites within its promoter. FoxM1 knockdown partially mitigated Gli2-driven fibrotic effects. Pharmacological Gli2 suppression with GANT61 alleviated fibrotic injury in the UUO mouse model. In conclusion, activated Gli2 is closely associated with renal tubulointerstitial fibrosis and may facilitate fibrogenesis in a FoxM1-relevant regulatory pattern. The TGF-β/Hedgehog/Gli2/FoxM1 axis represents a promising therapeutic target for combating progressive CKD. - Source: PubMed
Yuan ZiweiSun YiningKong LinxinYu ShenleiZheng FanYan PenghuaLiu BoyangHe DanniZuo YidanLu HongBai Yongheng - Rapid and stable regeneration of bone defects remains a pressing clinical challenge. We previously fabricated stem cell aggregates (CA) by mimicking developmental condensation and demonstrated their efficacy in promoting bone defect repair. Endogenous Gli1 skeletal stromal/progenitor cells (SSPCs) are a pivotal SSPC subtype known to maintain bone homeostasis and enhance bone regeneration; however, the functional properties and translational potential of CA derived from these cells (Gli1 CA) remain largely elusive. - Source: PubMed
Publication date: 2026/06/14
Ma ChaoGao Yu-RuWang HaoSui Bing-DongHuang Shan-ShanZhang YiLiu LuZhang Xiao-HuiXing Shu-JuanLi Yuan-YuanXiao Yi-HanZheng Ya-NanRen Li-HengJin YanZheng Chen-XiXu Hao-KunChen Ji