CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- AM08166PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- IntroductionTobacco use is known to have adverse effects on postoperative outcomes after Achilles tendon repair. Non-tobacco nicotine dependence (NTND) is increasing, but its association with outcomes of Achilles tendon repair remains unclear. The purpose of this study was to evaluate the association of NTND on perioperative and long-term outcomes after primary Achilles tendon repair. Study Design. This is a cohort study.MethodsA retrospective cohort study using the TriNetX database was conducted to identify patients who underwent primary Achilles tendon repair from 2004 to 2023. Patients were stratified into NTND (defined by International Classification of Diseases, 10th Revision diagnosis of nicotine dependence after excluding tobacco-specific codes), traditional tobacco nicotine dependent, and non-nicotine control cohorts. Propensity score matching was performed for demographics and comorbidities. Ninety-day and 2-year complications were compared using odds ratios (ORs) with 95% confidence intervals (CIs).ResultsOf 25 874 eligible patients, 1598 (6.2%) had NTND. After matching, 1592 NTND patients were compared with 1592 controls and 1592 tobacco users. Within 90 days, NTND patients demonstrated higher rates of wound dehiscence (OR, 1.98, 95% CI, 1.34-2.92), surgical-site infection (OR, 2.01, 95% CI, 1.32-3.08), emergency department visits (OR, 2.43, 95% CI, 1.84-3.20), and hospitalizations (OR, 3.35, 95% CI, 1.87-5.99) versus controls. Compared with tobacco users, NTND patients had greater odds of wound dehiscence (OR, 1.45, 95% CI, 1.02-2.06) and infection (OR, 1.89, 95% CI, 1.25-2.87). At 2 years, NTND patients showed higher re-rupture rates than both controls (OR, 1.39, 95% CI, 1.01-1.89) and tobacco users (OR, 1.62, 95% CI, 1.17-2.25)ConclusionNon-tobacco nicotine dependence was associated with increased short- and long-term complications after primary Achilles tendon repair. These findings identify NTND as a potential risk factor in patients undergoing Achilles tendon repair.Level of Evidence:. - Source: PubMed
Publication date: 2026/08/24
Florentino Samuel ABui VuKaszluga Christopher JBerk Alexander NGood Logan MMiniaci-Coxhead Sara LynRascoe Alexander SNapora Joshua K - Chronic exertional compartment syndrome (CECS) is a condition which involves sudden and painful increases in pressure of the musculofascial compartments of the lower leg in association with increased physical activity. A variety of surgical options, including endoscopic fasciotomy, exist to mechanically decompress the fascia. Recent progress in in-office needle endoscopy has shown potential for the diagnosis and treatment of various orthopaedic pathologies. We present the case of a 20-year-old collegiate sprinter with a 3-month history of CECS that was treated with bilateral in-office needle endoscopic 4 compartment fasciotomy. The patient was able to return to his previous level of competition 8 weeks postoperatively, and there were no complications. To the authors' knowledge, this is the first report of an in-office endoscopic 4-compartment fasciotomy for the management of CECS. . - Source: PubMed
Publication date: 2026/08/24
Robert GuillaumeButler James JPerskin CodyTham AlexanderRubin JaredGianakos Arianna LKennedy John G - Healthy aging is associated with structural and functional brain changes. However, cognitive abilities vary in how they change with age: executive functions decline, while aspects of linguistic processing remain relatively preserved. This heterogeneity predicts differences among brain networks in whether and how they change with age. To evaluate this prediction, we used precision fMRI to examine the language-selective network and the Multiple Demand (MD) network, which supports executive functions, in older adults (N = 64) relative to young controls (N = 483). The MD network of older adults shows weaker, less spatially extensive, and more topographically variable activations during an executive function task and reduced within-network functional connectivity. In contrast, we find remarkable preservation of the language network in older adults: it responds during language comprehension as strongly and selectively as in younger adults, with similar left-hemispheric lateralization and within-network functional connectivity. These findings align with behavioral preservation of language comprehension in healthy aging. - Source: PubMed
Publication date: 2026/08/24
Billot AnneJhingan NiharikaVarkanitsa MariaWolna AgataShain CoryBlank IdanRyskin RachelKiran SwathiFedorenko Evelina - Bone infection represents a pathological intersection of immunity and skeletal remodeling, where inflammatory responses drive excessive bone loss. Neutrophils dominate the early immune infiltration during infection, yet how neutrophil fate within infected bone marrow influences disease progression remains poorly understood. Here, we identify neutrophil-derived apoptotic bodies (Neut-ABs) as key mediators of bone protection during infectious osteomyelitis. Bone infection triggers extensive neutrophil apoptosis, resulting in the accumulation of Neut-ABs. Integrated transcriptomic and proteomic profiling of these Neut-ABs revealed significant enrichment of TLR2 and the sialyltransferase ST3GAL1, and lectin blotting confirmed that TLR2 is modified with α2,3-linked sialic acids. Mechanistically, α2,3-sialylated TLR2 on Neut-ABs functions as a molecular decoy that competitively interferes with Siglec15-TLR2 interactions in osteoclast precursors, thereby preventing precursor fusion and suppressing bone-resorptive activity. This inhibitory effect requires both the formation and sialylation of Neut-ABs, as it was abolished in Fas-deficient (MRL/Lpr) mice, upon neuraminidase-mediated desialylation, or when using Neut-ABs derived from Tlr2 mice. Therapeutic delivery of Neut-ABs markedly attenuates osteolysis in infected mice without altering bacterial clearance. These findings uncover a neutrophil-to-bone signaling axis in which sialylated vesicular decoys selectively suppress osteoclast activation, illuminating a new paradigm linking innate immune turnover to skeletal homeostasis. - Source: PubMed
Publication date: 2026/08/25
Yu QixiuQu YingZhang JieZhang ZiyangGuo ShuquanLuo FeiDou Ce - Ultra-high-field 7-T H-MRS resolves the bis-allylic resonance at 2.8 ppm, a marker present only in fatty acids (FAs) with two or more double bonds, enabling distinction between monounsaturated (MUFA) and polyunsaturated fatty acids (PUFAs) in IMCL that is not achievable at 3 T. The objective of this study was to determine the relative proportions of saturated (SFA), MUFA, and PUFA in IMCL in vivo using 7-T H-MRS. To further improve the precision of this fitting, we acquired high-resolution 600-MHz H-NMR spectra of representative FA species and incorporated their chemical shifts as prior knowledge in the spectral fitting model. Five predominant FAs-oleic, palmitic, linoleic, and α- and γ-linolenic acids, which together represent the major FA species in human skeletal muscle triglycerides-were analyzed via 600-MHz NMR to determine precise chemical shifts for methyl (-CH), allylic (-CH-CH=CH-), and bis-allylic (=CH-CH-CH=) protons. The NMR spectra revealed distinct shifts: linoleic acid (0.891, 2.044, and 2.782 ppm), oleic acid (0.878 and 2.002 ppm), palmitic acid (0.880 ppm), α-linolenic acid (0.976, 2.064, and 2.807 ppm), and γ-linolenic acid (0.889, 2.074, and 2.808 ppm). These values were subsequently fitted to in vivo 7-T H-MRS spectra (range of 0.90-5.55 ppm) acquired from the tibialis anterior of 11 healthy volunteers. Using specialized analysis software, IMCL peaks for methyl (0.90 and 1.00 ppm), allylic (2.02 and 2.06 ppm), and bis-allylic (2.78 and 2.82 ppm) protons were incorporated into the spectral fitting model, enabling improved characterization of FA composition. The mean relative composition of intramyocellular FAs was 36% palmitic acid, 27% oleic acid, and 23% linoleic acid (including α- and γ-linolenic acids). Our findings demonstrate that incorporating NMR-derived prior knowledge enables chemically specific fitting of intramyocellular FA peaks, allowing distinction between SFA, MUFA, and PUFA components within the intramyocellular compartment-information that cannot be obtained from biopsy-based homogenate analysis. - Source: PubMed
Hioki MayaUmeda MasahiroKawai YukoFukunaga Masaki