CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- AM08166PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Hepatic steatosis is an early key event in metabolic dysfunction-associated steatotic liver disease, for which safe and effective interventions for reducing hepatic lipid accumulation are needed. To this end, we investigated the anti-steatotic effect of combining probiotics BR3 and LP3 (BR3LP3) on an oleic acid (OA)-treated human hepatocellular carcinoma (HepG2) cell model and an high-fat diet (HFD)-induced obese mouse model. In the OA-treated HepG2 cell model, BR3LP3 reduced OA-induced lipid accumulation without exhibiting cytotoxicity and modulated lipogenesis-related protein expression, while in the HFD-fed obese mouse model, oral BR3LP3 supplementation reduced body weight, fat mass, liver weight, and epididymal adipose tissue weight and improved several serum lipid, liver injury-related, and metabolic hormone parameters without affecting food intake. Moreover, when comparing BR3LP3-supplemented mice with those fed the HFD only, the former revealed reduced hepatic lipid droplet accumulation via histological analysis, while the expression levels of sterol regulatory element-binding protein-1c (), peroxisome proliferator-activated receptor γ (), CCAAT/enhancer-binding protein alpha (), acetyl-CoA carboxylase (), and fatty acid synthase () were lower. Hence, our findings indicate that BR3LP3 supplementation attenuates hepatic lipid accumulation and the expression of hepatic lipogenesis-related markers while improving adiposity and systemic metabolic parameters. This suggests that BR3LP3 supplementation is a promising probiotic dietary strategy for improving hepatic steatosis and related metabolic dysfunction. - Source: PubMed
Publication date: 2026/08/12
Yeo YeongjuKim Jong WonChung YusookKong GyeyeongYun MisunLim Sanghyun - Chandipura virus (CHPV) is an emerging neurotropic RNA virus and member of the Rhabdoviridae family, causing outbreaks of acute encephalitis in India, mostly in children under 15 years of age. The manuscript reviews in detail the virology, genetics, clinical features, epidemiology, transmission, immunopathogenesis, and treatment of CHPV. CHPV rapidly infects neuronal tissue and activates the extrinsic pathways of neuronal apoptosis through Fas-mediated apoptosis, resulting in rapid neuronal degeneration within 24-48 h. The recent re-emergence of CHPV is another significant re-emergence in Gujarat in 2024, with the distribution of cases by space and time further suggesting CHPV is seasonal, adds new districts, and is still a threat to children. Outbreaks of CHPV typically coincide with monsoonal flooding, and Phlebotomus sandflies primarily spread the disease. The monsoonal flooding and environmental degradation that occurred during the breeding season, rendering sandflies more susceptible to outbreaks, are remarkable. Differentiation of other encephalitic viruses, such as Japanese encephalitis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and dengue, is important for clinical diagnosis and also because of the rapid progression of CHPV. Several points to consider are low CSF pleocytosis and the neuroimaging characteristics that are identifiable. The immune response after infection is marked by a cytokine storm, followed by lymphocyte apoptosis and reduction in CNS viral clearance. Over the past decade, laboratories in India have developed in the realm of diagnosis and treatment of CHPV with the advent of molecular diagnostics such as real-time RT-PCR and IgM ELISA. However, a lack of a licensed vaccine and antivirals would make this new infectious disease more difficult to manage. This review highlights the critical importance of further surveillance, vector control, public health preparedness, and vaccine development/therapeutics for CHPV. - Source: PubMed
Publication date: 2026/08/26
Rahim AbdulKhan Md NasiruddinMehan SidharthKhan ZuberAhamad MustakHaque Injamamul - Nutritional interventions play a pivotal role in sustaining egg production performance and improving egg quality parameters in aged laying hens. The present study was conducted to investigate the effect of L-carnitine (LC) supplementation in diets containing different levels of fish oil (FO) on performance, egg quality parameters and egg yolk fatty acids (FAs) profile in aged laying hens. In this study, 432 laying hens (Hy-line-W36, 65 weeks of age) were used and allocated in a 3 × 3 factorial design with six replications and eight birds replication. The experimental treatments included diets containing three levels of FO (0.00, 1.50 and 3.00% of the diet) and three levels of LC (0.00, 300, and 600 mg kg of the diet). The results showed that hens treated with 3.00% FO and 300 and 600 mg LC had the highest egg production rate, egg weight and egg mass which was significantly higher than the treatments without FO and LC. With increasing usage level of FO to 3.00% of diet, egg yolk pH was significantly decreased, however, yolk pH was increased when diet was supplemented with 600 mg LC. The percentage of polyunsaturated FAs, the ratio of polyunsaturated FA/saturated FAs and the percentage of omega-3 FAs were increased significantly with increasing FO usage level in the diet. Overall, these findings suggested that dietary supplementation with FO and LC could synergistically improve productive performance and enhance the nutritional value of eggs in aged laying hens. - Source: PubMed
Publication date: 2026/05/15
Dhihab Ali MahdiMirghelenj Seyed AliDaneshyar MohsenKhalilvandi-Behroozyar Hamed - Generate psychometric validity evidence for a novel 4-item measure of trust in public health actors for vaccine information for use in U.S.-population survey research. - Source: PubMed
Publication date: 2026/08/25
Gutierrez Amanda MDo My HMotta Matthew - Long-chain omega-3 fatty acids (ω-3 FAs), particularly eicosapentaenoic acid (EPA, C20:5 ω-3) and docosahexaenoic acid (DHA, C22:6 ω-3), are widely used in canine medicine as nutritional adjuncts in chronic inflammatory and degenerative diseases. Blood-based biomarkers, especially erythrocyte fatty acid composition, provide an integrated measure of long-term ω-3 FA exposure and are less susceptible to short-term dietary fluctuations than plasma indices. Within this framework, the Omega-3 Index (O3I) - the sum of 2 prominent long-chain ω3 fatty acids (EPA and DHA) in erythrocyte membranes, expressed as a percentage of total erythrocyte FAs - offers a standardised, biologically anchored metric of ω-3 FA status with potential relevance for clinical evaluation and monitoring. Studies in healthy dogs demonstrate low baseline O3I levels, while dietary supplementation with marine-derived ω-3 FAs reliably increases both circulating plasma concentrations and erythrocyte-based indices of ω-3 FA status. In dogs with chronic diseases such as osteoarthritis, cardiac diseases, and selected gastrointestinal disorders, reduced ω-3 FA status is observed and supplementation results in measurable biochemical changes (lower content of triglyceride and total cholesterol, better antioxidant status, reduced production of prostaglandin E2 and interleukin-6). In contrast, comparable erythrocyte-based data are very limited in canine dermatology. Although species-specific reference ranges and outcome-based targets are not yet established, assessment of ω-3 FA status offers a promising tool for monitoring FA supply, guiding supplementation and supporting individualised clinical nutritional management in canine practice. - Source: PubMed
Publication date: 2026/08/25
Tóth Zsombor TamásTarpataki NoémiMátis GáborFébel Hedvig