CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- 6L95
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Diabetic kidney disease (DKD) is a type of chronic renal injury induced by diabetes mellitus and is characterized by persistent proteinuria and progressive decreases in the glomerular filtration rate. Recent studies have highlighted the significance of histone lactylation and necroptosis in the pathogenesis of DKD. We explored the mechanisms by which lactate-induced histone H3 lysine-18 lactylation (H3K18la) and H3K27la promote necroptosis in DKD. Lactate-induced H3K18la and H3K27la modulated Fas transcription, contributing to necroptosis and DKD progression. Moreover, keratin 18 (KRT18), identified as a lactyltransferase, regulated H3K18la and H3K27la levels, subsequently inducing Fas transcription and necroptosis. Furthermore, ginsenoside Rc (gRc) inhibited KRT18 lactyltransferase activity by competing for the lactate binding site in KRT18. Notably, gRc treatment reduced the KRT18, H3K18la, H3K27la, and Fas levels and alleviated necroptosis and renal dysfunction in DKD models. In conclusion, KRT18 functions as a lactyltransferase to induce Fas transcription and necroptosis. Moreover, inhibiting KRT18-mediated histone lactylation via gRc is a potential strategy for treating DKD. - Source: PubMed
Publication date: 2026/06/12
Zhao QiaoLiu XuYang YangliangMeng FufenMeng ZhipengZhu Minmin - Cell migration across epithelial barriers occurs in diverse developmental, immunological, and pathological contexts. Here, we investigate the contribution of heterotypic adhesion between migrating cells and epithelial "substrate" cells to transepithelial migration. Using an in silico model inspired by the migration of primordial germ cells across the midgut epithelium in the embryo, we show that heterotypic adhesion modulates migration efficiency in a nonmonotonic manner, revealing the existence of an optimal adhesion regime. Consistent with this prediction, in vivo overexpression of E-cadherin in germ cells accelerated their exit from the midgut relative to controls. Beyond providing experimentally testable predictions, our model integrates and explains previous observations on the role of heterotypic adhesion in cell-on-cell migration, offering a framework for understanding transepithelial migration across biological contexts. - Source: PubMed
Publication date: 2026/06/12
Kuyyamudi ChandrashekarGhosh SuhridExtavour Cassandra G - Type 2 diabetes (T2D) impairs antiviral immunity; however, the causal link between T2D and interferon-α2 (IFN-α2) deficiency remains unclear. This study used genome-wide association study-based Mendelian randomization (MR) to investigate this relationship and validated the findings in an H1N1-infected diabetic mouse model. MR analysis of 26 single nucleotide polymorphisms showed a significant negative association between T2D and IFN-α2 levels (inverse variance weighted odds ratio 0.667; P = 0.000116) without heterogeneity or pleiotropy. In vivo experiments confirmed that db/db mice exhibited more severe H1N1-induced lung injury, higher viral loads, and lower survival rates compared with nondiabetic controls. However, exogenous IFN-α2 treatment significantly reversed these pathologic outcomes. Inflammatory cytokine profiling showed that IFN-α2 downregulated 21 elevated cytokines and restored Fas ligand levels in lung tissue. Mechanistically, Western blotting demonstrated that IFN-α2 inhibited the phosphorylation of JAK1/2 and STAT3, thereby suppressing excessive inflammation. In conclusion, our findings indicate that T2D leads to IFN-α2 deficiency, contributing to susceptibility to viral infection. Supplementation with IFN-α2 effectively attenuated virus-induced lung injury by inhibiting JAK/STAT3 signaling and cytokine storms, positioning IFN-α2 supplementation as a promising therapeutic strategy for managing influenza complications in patients with diabetes. - Source: PubMed
Publication date: 2026/06/12
Lyu SiyeWu JialiMa WeihuiSun LipingXing SihuiZhang HaiyangShao FengyanLi MingquanZhu YilongXiong XiaomiaoHan Jicheng - Since its inception over four decades ago, numerous types and modifications to functional analysis (FA) have been published, likely in part to provide practitioners with a feasible, acceptable, safe, and ecologically valid assessment to inform the treatment of problem behavior. Even so, there are still cases in which an FA is not possible in a given setting or yields undifferentiated results, making conclusions from the FA difficult to interpret. Rather than relying on less rigorous and precise assessment methods (e.g., indirect reports) as part of the functional behavior assessment (FBA) process to inform treatment, a practitioner could employ a concurrent operant analysis (COA). A COA is an assessment that relies on direct observation and experimental manipulations that may be useful for supplementing the FBA process when an FA is not ideal or possible. Further, COAs may be beneficial in that they may avoid the potential drawbacks and criticisms (e.g., evoking problem behavior) that may be more likely associated with FAs than COAs. Despite the benefits of a COA, it has been slow to appear in research for the assessment and treatment of problem behavior. In this clinical tutorial, we provide a comprehensive, step-by-step description using hypothetical, illustrative examples, along with several resources to assist in developing, implementing, and analyzing a COA. - Source: PubMed
Publication date: 2025/08/25
Randall Kayla RKranak Michael P - The phytopathogenic bacterium () infects a wide range of crop plants and causes substantial economic losses. The authors of this study previously demonstrated that the selenium-arabinogalactan nanocomposite (Se/AG NC) is capable of mitigating the negative effects of infection of soybean seeds with during germination and can influence physiological and biochemical factors in the seedlings. This study investigated changes in the membrane fatty acid (FA) profile of soybean seedlings grown under different treatments and in control using chromatography-mass spectrometry (CMS). The soybean seed treatments included the following: (1) infection by alone; (2) nanopriming with Se/AG NC alone; and (3) infection by followed by nanopriming with Se/AG NC. The infection was performed by soaking seeds in a bacterial suspension. Nanopriming was performed by placing the seeds in an aqueous solution of Se/AG NC (6.25 µg/mL) with a Se concentration of 0.000625%. Then, the seeds were germinated over 5 days in the darkness at 25 °C. The FA profile of soybean seeds was characterized by 13 FAs dominated by linoleic (LA), linolenic (LNA), oleic (OA), palmitic (PA) and stearic (SA) acids. Se/AG NC nanopriming had no influence on the FA profile of soybean seeds. A unique FA profile of soybean seedlings was demonstrated. It consisted of 18 FAs containing 12 to 20 carbon atoms. The following FAs were dominant in the control samples: PA (28%), LA (32.8%), LNA (18.6%), and SA (7.5%). infection of the seeds amplified the content of unsaturated FAs. Nanopriming of the seeds with Se/AG NC had an obvious influence on the seedling FA profile. Treatment of soybean seeds infected with using Se/AG NC caused weakening of the detrimental effects of the pathogen, while giving the possibility to maintain soybean seedlings' FA profile at the control level. Transcript levels of the gene encoding the membrane-bound omega-3 FA desaturase (FAD) were elevated for soybean seedlings after both and Se/AG NC seed treatment processes. The FA double-bond index (DBI) grew under the influence of seed infection and dropped under other treatments. Nanopriming of the seeds with Se/AG NC effectively reduced stress in -infected plants, as evidenced by analysis of the abscisic acid (ABA) content. Variations in the membrane FA composition under nanopriming with Se/AG NC may be one of the forms of its phytoprotective effect. - Source: PubMed
Publication date: 2026/05/27
Perfileva Alla ISemenova Natalia VGarnik Elena YuKorobova Alla VKlushina Nadezhda VSukhov Boris GKapustina Irina SNurminsky Vadim N