CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- 4Fs41-SA7
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- This study aimed to characterize the nutritional and sensory profiles of commercial liquid milk available in China (CN) from three different major global regions. Sixteen milk samples [six from CN, five from Western Europe (WEU), and five from Australia/New Zealand (ANZ)] were analyzed for macronutrients, minerals, vitamins, fatty acids (FAs), and sensory properties. CN milk had higher levels of fat, zinc, iodine, vitamin E, and vitamin B3, whereas imported milk contained more vitamin B2. Distinct FA profiles were observed: CN milk was richer in n-6 FAs, whereas imported milk had higher n-3 FAs and a more favorable n-3/n-6 ratio. Sensory analysis showed that imported milk exhibited stronger 'cowy' and 'tea' flavors. These variations were mainly caused by different feeding systems (total mixed rations-based confined production in CN vs. pasture-based grazing in WEU and ANZ), along with milk processing and supply chain factors. The results provide evidence for dairy product differentiation and help Chinese consumers make informed purchasing decisions. - Source: PubMed
Publication date: 2026/07/01
Yang JinhuiWang MenghuiHu PengliLi ShashaQian WentaoLi Hongliang - Concentrated bone marrow aspirate (cBMA) is an autologous biologic increasingly used in orthopaedic surgery for its regenerative potential. It contains mesenchymal stem cells (MSCs), growth factors, and cytokines that contribute to tissue repair and immunomodulation. Mesenchymal stem cells primarily exert their effects through paracrine signaling and macrophage reprogramming, promoting a shift from a pro-inflammatory (M1) to a reparative (M2) phenotype. Emerging evidence also suggests a role for mitochondrial transfer in this process. In foot and ankle surgery, cBMA has been investigated in the management of osteochondral lesions of the talus, fracture healing, and tendon disorders. Early clinical studies suggest potential improvements in functional outcomes, healing rates, and revision rates; however, the available evidence remains heterogeneous and is largely limited to small, non-randomized studies. Variability in cBMA preparation and reporting further limits comparability across studies. As such, while cBMA represents a promising adjunct in foot and ankle surgery, its clinical role is not yet fully defined. Future research should focus on prospective, controlled studies with standardized methodologies and explore emerging cell-free approaches, including MSC-derived extracellular vesicles, to optimize regenerative strategies. - Source: PubMed
Publication date: 2026/07/01
Tham AlexanderRubin JaredButler James JMontgomery Samuel RMercer Nathaniel PLezak Bradley AMojica EdwardCharalambous LefkoKennedy John G - BackgroundLigament and tendon pathology of the ankle is frequently complicated by chronic instability, poor tissue quality, and prior failed repairs. Augmentation devices have been introduced to reinforce primary repair and protect healing tissues during the early postoperative period. A novel synthetic augmentation device was used as an adjunct in primary ankle ligament repair across a range of clinical presentations.MethodsThis retrospective case series evaluates early clinical outcomes in 5 patients who underwent ankle ligament repair augmented with TEKBRACE (Theramicro, Cordova, Tennessee). The cohort included 3 males and 2 females with a mean age of 52 years (range, 37-65) and mean body mass index of 29.9 (range, 22.7-39.1). Diagnoses included acute lateral instability (n = 3), acute-on-chronic instability (n = 1), and chronic instability with concomitant tendinopathy (n = 1). All diagnoses were confirmed by clinical examination and magnetic resonance imaging. Mean follow-up was 18 weeks (range, 16-24 weeks). All patients followed a standardized postoperative immobilization and rehabilitation protocol.ResultsAt early follow-up, all patients demonstrated stable clinical courses without device-related complications. There were no postoperative infections, wound complications, thromboembolic events, skin reactions, or mechanical failures. Visual Analog Scale pain scores improved from a mean of 4.8/10 preoperatively to a mean of 0.6/10 at final follow-up. Range of motion was within normal limits compared to preoperative baseline in all patients. Four of 5 patients returned to full unrestricted activity. No gross instability was detected on clinical examination at any postoperative visit.ConclusionEarly outcomes following TEKBRACE augmented ankle ligament repair were encouraging in this small preliminary series, with no device-related complications observed. These findings support the feasibility of the technique and provide rationale for prospective investigation with standardized outcome collection and longer follow-up. - Source: PubMed
Publication date: 2026/07/01
Simpson G Alexander - Predicting the efficacy and toxicity of mRNA vaccines remains challenging. We describe an human model that replicates immune responses to lipid nanoparticle (LNP)-based mRNA vaccines upon intramuscular injection. Vaccines are administered to human skeletal myoblasts and antigen-presenting cells (APCs). Non-amplifying mRNA (NAM) vaccines directly induce antigen expression in APCs, whereas self-amplifying mRNA (SAM) vaccines require muscle cell-APC contact. The transfer of APCs and soluble factors to a microfluidic human lymphoid follicle chip (LF Chip), to mimic lymphatic drainage, induces LF expansion, immunoglobulin G (IgG) production against a naive antigen, and cytokine release, with responses varying by LNP type. Similar vaccination of LF chips with Moderna vaccine against SARS-CoV-2 spike recall antigen generates neutralizing antibodies and induces somatic hypermutation (SHM). These studies offer an all-human alternative for evaluating vaccine-induced immunity, limiting the need for non-human primates and accelerating vaccine development. - Source: PubMed
Publication date: 2026/06/20
Zhai YunhaoKu Min WenYang KaPatil AdityaPrabhala PranavHe LiqunMan YunchengRahman MizanurMenon KavyaSpörri Sven BGharpure SupriyaIsaacs Abdul RahmanFerdosi ShayPitek Andrzej SMaruggi GiuliettaBertholet SylvieFirestone JessicaMousavi KambizMiller EricLuisi KateHellman Caleb AWilliams LaTonya DTomaras Georgia DYin PengGygi Steven PMcAuliffe JosieIngber Donald EGoyal Girija - Fasciculations can be detected using both muscle ultrasonography and needle electromyography, yet the correspondence between ultrasonographically observed fasciculations (U-fas) and needle electromyography-detected fasciculation potentials (N-fas) has not been clarified. This study investigated their correspondence using fully synchronized recordings. - Source: PubMed
Publication date: 2026/06/13
Sugimoto TakamichiTachiyama KeisukeHironaka AkemiNaito HiroyukiNakamori MasahiroAoki ShiroYamazaki YuMaruyama Hirofumi