CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- 2433
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- In pigs, energy homeostasis has an impact on meat quality and health. In a Duroc pig population, 30 quantitative trait locus (QTL) regions associated with fatty acid (FA) composition in adipose tissue, plasma, liver and muscle were previously identified. Mapping of expression quantitative trait locus (eQTL) regions will provide a molecular hypothesis for genotype-phenotype interactions and may allow the identification of shared causal variants, key to increasing our understanding of the genetic regulation of FA composition and energy homeostasis. However, gene expression is impacted by environmental factors, while individual-level allelic imbalance (AI) can be more reliable and can be surveyed via allelic-specific expression (ASE) analysis. Furthermore, treatment of ASE as a quantitative trait allows the identification of allele-specific expression quantitative trait loci (aseQTLs), which are variants whose heterozygosity is linked to the AI of a nearby single-nucleotide polymorphism (SNP), pointing to regulatory elements. In this study, liver was selected as a key metabolic hub with an important role in the regulation of energy homeostasis, and 310 liver RNA sequencing samples were analysed using a combination of (1) eQTL mapping, (2) ASE analysis, and (3) aseQTL mapping methods. A total of 2 188 eQTL regions were identified, mostly cis-eQTL regions (73.17%). ASE analysis reported 1 964 ASE SNPs, associated with 633 genes. Finally, aseQTL mapping reported 64 172 aseQTL, associated with the AI of 31 genes. Colocalisation analysis combined with ASE analysis showed that the expression of FADS1 and FADS2 genes is associated with the polyunsaturated FA composition in several tissues, where microRNA regulation may be present. Finally, in the DGAT2 gene, annotated in a QTL region associated with multiple FAs in adipose tissue, ASE revealed allelic imbalance in the 3' untranslated region (UTR) of this gene. Allelic differential expression can be caused by a 13-bp insertion affecting messenger RNA stability, previously described, exemplifying how allelic imbalance is caused by a post-transcriptional regulatory mechanism undetectable by eQTL mapping. Furthermore, aseQTLs were associated with this gene, linked to a previously identified copy number variant not yet associated with DGAT2 expression. These results demonstrate how ASE analysis and aseQTL mapping can complement eQTL mapping, as they resolved a complex region affected by allelic heterogeneity, a main confounding effect of QTL mapping. In conclusion, the combination of eQTL mapping, ASE analysis and aseQTL mapping allowed the characterisation of the regulation of liver gene expression, improving our understanding of the genetic determinism of energy homeostasis. - Source: PubMed
Publication date: 2026/08/26
Llobet-Cabau FLiu JJové-Juncà TCastelló AQuintanilla RSánchez ABallester MFolch J M - Angus and Hereford cattle are premier breeds widely used in genetic improvement and crossbreeding programs to enhance meat quality, yet the flavor differences between them remain poorly understood. - Source: PubMed
Publication date: 2026/09/16
Yang XiaoruiPeng LingweiDai XueleiLi YichongHuang LeiLi ZhiqiangHuang XinaiZhang WengangLyu YangDing HeLiu HongyuZhao JingZhou YangLv Wen-Fa - Metabolic reprogramming has recently been recognized as a hallmark of cancer. In acute myeloid leukemia (AML), clinically relevant metabolism-targeted therapies have primarily focused on inhibiting mitochondrial energy production; however, their clinical progress has been limited by substantial and nonspecific toxicity. Emerging evidence indicates that reprogramming of lipid metabolism represents a defining feature of leukemic transformation. Lipids not only serve as fundamental structural components of cellular membranes but also function as key signaling molecules and energy sources. In AML cells, lipid uptake, storage, and synthesis are markedly increased, thereby supporting rapid proliferation, survival, and leukemic progression. Consequently, dysregulated lipid metabolism has attracted growing attention as a promising therapeutic vulnerability in AML. This review summarizes the conceptual framework underlying AML cell dependence on cholesterol, fatty acids (FAs), sphingolipids, and broader lipid metabolic pathways. We highlight recent advances in understanding aberrant lipid metabolic programs in AML, including alterations in cholesterol biosynthesis, FA uptake and lipogenesis, FA oxidation, and sphingolipid metabolism. Particular emphasis is placed on the regulatory mechanisms that maintain lipid metabolic homeostasis and how their disruption contributes to leukemogenesis and therapy resistance. Furthermore, we discuss emerging therapeutic strategies aimed at targeting lipid metabolic pathways, with a focus on small-molecule inhibitors that selectively interfere with lipid metabolism-associated enzymes and signaling networks. By delineating key molecular targets and their pharmacological inhibitors, this review highlights the potential of lipid metabolism-based interventions as innovative and effective treatment strategies for AML. - Source: PubMed
Publication date: 2026/07/25
Yen Jui-HungPhan Trung QLiou Je-WenChen Pei-Yi - Baicalin is an ingredient of Qinbai Qingfei concentrated pills that is first new traditional Chinese medicine proved by SFDA for the treatment of pneumonia in children. We aim to investigate the role of Baicalin in the treatment of by inhibiting the ADP-ribosyltransferase of the D1 structural domain in the sole toxin CARDS TX of to down-regulating the expression of G-protein-coupled receptor. - Source: PubMed
Publication date: 2026/09/11
Liqiao YinYi SunHaifeng ZhangHongfei MaXuelin GeShuang LiangPing WangJin ChenFang FangWeiming WangYanli MengGuixin Tang - Despite growing interest in starch-lipid complexes as prebiotic ingredients, the impact of fatty acid (FA) unsaturation on their fermentative behavior and gut microbiota modulation remains controversial, largely due to inconsistent structural characterization across studies. Herein, lotus seed starch (LS), notable for its high amylose content, was used to systematically fabricate complexes with C18 FAs of varying unsaturation, such as stearic (SA), oleic (OA), linoleic (LA), and α-linolenic (ALA) acids, via dynamic high-pressure microfluidization. Complex stability and digestive resistance decreased with increasing FA unsaturation. LS-SA exhibited the slowest digestion and enriched butyrate-producing genera (Bifidobacterium, Clostridium). LS-OA promoted Sutterellaceae, potentially linked to β-oxidation. LS-LA and LS-ALA enhanced unclassified_c__Bacilli, Litchfieldia, and Turicibacter, with LS-LA also stimulating Ligilactobacillus, known for conjugated linoleic acid production. Notably, LS-ALA significantly boosted acetate, propionate, and butyrate levels. These findings suggest that differences in FA unsaturation are associated with the structural stability and prebiotic efficacy of LS-FA complexes through synergistic effects between the starch matrix and FA ligand. This work clarifies previous contradictions regarding FA unsaturation and provides a mechanistic framework for the rational design of starch-based formulations aimed at targeted modulation of gut microbiota. - Source: PubMed
Publication date: 2026/09/10
Liu LuWang HaoyuLuo FujingZhang YiZheng BaodongGuo Zebin