aCella™ _ AChE
- Known as:
- aCella™ _ AChE
- Catalog number:
- S-9094.1000
- Product Quantity:
- 1000T
- Category:
- Cells
- Supplier:
- Bach
- Gene target:
- aCella™ _ AChE
Related genes to: aCella™ _ AChE
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: aCella™ _ AChE
Related articles to: aCella™ _ AChE
- To evaluate a six-week Postpartum Comprehensive Health Intervention Program (PCHIP), a health literacy-based digital intervention designed to promote early postpartum self-care and selected recovery outcomes. This pre-registered, two-arm, single-blind randomized controlled trial was conducted at Changzhou Second People's Hospital, Changzhou, China. Participants were primiparous women (mean age 29.75 years) recruited from January 25 to February 15, 2025 and enrolled within the first three days postpartum. Eighty-eight participants were randomized 1:1 using a computer-generated sequence, with allocation concealed in sealed opaque envelopes, to PCHIP plus standard education or standard education alone. PCHIP began on postpartum day 3 and lasted six weeks. Primary outcomes were eating behaviors, physical activity, and breastfeeding practices; health literacy and recovery indicators were secondary outcomes. Complete-case analyses included 82 women. ANCOVA was used for continuous outcomes with baseline values, weight-related outcomes were adjusted for baseline postpartum weight, and Fisher's exact test was used for exclusive or predominant breastfeeding. Eighty-two participants completed follow-up (PCHIP: 40/44; control: 42/44). Baseline-adjusted analyses showed lower pain (AMD = -0.698, 95% CI: -1.339 to -0.057), depression (AMD = -1.313, 95% CI: -2.398 to -0.229), anxiety (AMD = -1.357, 95% CI: -2.543 to -0.170), emotional eating (AMD = -4.421, 95% CI: -8.177 to -0.666), and external eating (AMD = -4.043, 95% CI: -7.957 to -0.129), and higher health literacy (AMD = 2.714, 95% CI: 0.032 to 5.397) and physical activity (AMD = 0.969, 95% CI: 0.227 to 1.711) in the PCHIP group. Restrained eating showed a favorable but non-significant trend. Weight-related analyses adjusted for baseline postpartum weight showed greater weight reduction in the PCHIP group (AMD = 2.527 kg, 95% CI: 0.835 to 4.218). Outcomes measured only at 6 weeks suggested shorter red lochia duration (MD = -1.224 weeks, 95% CI: -1.811 to -0.638), better selected pelvic floor muscle indicators, and more frequent exclusive or predominant breastfeeding (risk difference = 22.6%, 95% CI: 2.4% to 42.8%) in the PCHIP group. No adverse events were reported. PCHIP may support early postpartum self-care and selected recovery outcomes, but findings should be interpreted cautiously because of the single-center design, small sample, complete-case analysis, short follow-up, and multiple outcomes. Larger multicenter trials with longer follow-up are needed. The trial was prospectively registered with the Chinese Clinical Trial Registry (ChiCTR2500096473) on January 24, 2025. - Source: PubMed
Publication date: 2026/06/18
Wang ZhulinLi Qian - Non-specific low back pain (NSLBP) represents about 80-95% of all LBP cases, yet the optimal lumbar traction position for effective treatment remains debated. To investigate the effect of different positions during lumbar traction on pain, function, and ROM in adults with NSLBP. Thirty participants were randomly allocated to one of three lumbar traction position groups: supine, side-lying, or prone. Outcome measures included the Oswestry Disability Index (ODI), International Physical Activity Questionnaire short form (IPAQ-SF), Finger-to-Floor Test (FFT), and Numerical Pain Rating Scale (NPRS). Measurements were obtained at baseline, after the third session, and after completion of the 3-week intervention. Within-group analysis showed significant improvements in ODI and NPRS scores over time in all three groups (p < 0.001). The supine group demonstrated earlier within-group improvement after the third session (p = 0.012). IPAQ improved significantly only in the side-lying group (p = 0.01), whereas FFT did not show significant changes in any group (p > 0.05). However, between-group analysis revealed no statistically significant differences among the three traction positions at any measurement point for any outcome (p > 0.05). Lumbar traction was associated with improvements in pain and disability regardless of position. However, no traction position demonstrated superiority over the others. The earlier improvement observed in the supine group should be interpreted cautiously because it was based on within-group change rather than between-group superiority. Future studies with larger samples are needed to clarify whether positional differences are clinically meaningful. Also, these findings are limited to male participants and should not be generalized to female populations.Trial registration: The trial was registered on 02/02/2025, clinicaltrials.gov, Identifier: (NCT06812338). - Source: PubMed
Publication date: 2026/06/17
Mahmoud Waleed SAlhowimel AhmedAlmotery AbdalmajedHafiz Kamel MustafaHassan Sahar MahmoudMazen Mohamed Mohamed - Osteoarthritis pain is a common chronic pain. Low intensity pulsed ultrasound (LIPUS) is a non-invasive treatment commonly used for musculoskeletal system diseases, but it is unclear whether it can alleviate osteoarthritis (OA) pain. The aim of this study is to investigate the therapeutic effects of LIPUS on pain relief and joint repair in OA rat models, and to explore its potential mechanisms. - Source: PubMed
Publication date: 2026/06/17
Liu ZhihuaDong YangXu PengChen Xia - While both dopamine type 2 receptor antagonists and the muscarinic MR M/MR agonist xanomeline (KarXT) have shown to be effective in treating positive and total symptoms of schizophrenia, full or partial treatment resistance is common, particularly for negative symptoms and cognitive impairment associated with schizophrenia (CIAS). Based on the concept of targeting excitatory-inhibitory (E/I)-imbalance, serotonin type 3 receptor (5-HTR) antagonists may have utility as an adjunctive treatment for residual symptoms in schizophrenia. We present a meta-analysis of 5-HTR antagonists (setrons, CVN058 and the antidepressant vortioxetine) for CIAS and negative, positive and total symptoms. 12 active- vs. placebo-arm comparisons across 730 participants met the inclusion criteria. Meta-analyses of both negative symptoms [Cohen's d = -0.52 (95%CI: -0.78, -0.27), p = 0.012] and CIAS [Cohen's d = -0.53 (95%CI: 0.09, 0.97), p = 0.02] support a significantly greater effect for active drug at a moderate effect size. The results support the potential utility not only of "setron" type 5-HTR antagonists, but also of vortioxetine, which has significant 5-HTR antagonist properties along with more general anti-depressant features. Results argue for definitive multicenter studies of adjunctive 5-HTR antagonists in schizophrenia. - Source: PubMed
Publication date: 2026/06/17
Mayer Megan RChoo Tse-HweiJavitt Daniel CKantrowitz Joshua T - Preoperative muscle strength is an important predictor of functional recovery after total hip arthroplasty (THA); however, accurate assessment is difficult in patients with severe hip pain. In this study, we developed a two-stage deep-learning framework that combines slice-level classification and U-shaped convolutional neural network-based segmentation to automatically quantify periarticular and thigh muscle volumes from preoperative computed tomography (CT) images. The model was trained using CT scans from 107 patients undergoing primary THA and was validated against manual segmentation. The model was subsequently applied to an independent cohort of 58 patients to examine the associations between preoperative muscle volume indices and postoperative clinical outcomes. Automated segmentation demonstrated high agreement with manual measurements, with absolute volume errors of 1-10% and Dice coefficients exceeding 0.89 across all muscle groups. In the clinical cohort, the preoperative muscle volumes were significantly lower on the affected side than on the unaffected side. Greater preoperative volumes of the gluteus maximus, quadriceps, and hamstrings were significantly associated with postoperative hip abductor strength and Timed Up and Go test performance, whereas gluteus medius/minimus volumes showed weaker associations. These findings support the feasibility of automated CT-based muscle volumetry for objective functional assessment in THA. - Source: PubMed
Publication date: 2026/06/18
Tachibana TetsuyaKatagiri HirokiEsaki ToruKawashima TomoakiMizuno TakahisaOgawa TakahisaSaito RyusukeJinno Tetsuya