GSTO1, 1_241aa, Human, E.coli
- Known as:
- GSTO1, 1_241aa, Human, E.coli
- Catalog number:
- ATGP0474
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- GSTO1 1_241aa Human .coli
Related genes to: GSTO1, 1_241aa, Human, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- GSTO1 NIH gene
- Name:
- glutathione S-transferase omega 1
- Previous symbol:
- -
- Synonyms:
- GSTTLp28, P28
- Chromosome:
- 10q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-01
- Date modifiied:
- 2015-09-11
Related products to: GSTO1, 1_241aa, Human, E.coli
Related articles to: GSTO1, 1_241aa, Human, E.coli
- Perioperative neurocognitive disorders (PND) are common and devastating perioperative neurological complications that markedly hinder postoperative rehabilitation and impair long-term quality of life in elderly surgical patients. Oxidative stress and neuroinflammation are well-established core pathogenic drivers of PND, whereas the key molecular mediators bridging perioperative stress and cognitive dysfunction remain poorly elucidated. Glutathione S-transferase Omega 1 (GSTO1) is a multifunctional deglutathionylase that centrally governs intracellular redox homeostasis and inflammatory signal transduction. Notably, no direct clinical or preclinical perioperative evidence has validated the modulatory effects of surgical trauma or anesthetic exposure on GSTO1 expression and catalytic activity, identifying GSTO1 as a promising yet unverified molecular linker between perioperative oxidative/inflammatory insults and PND progression. Accumulating indirect mechanistic evidence from chronic neurodegenerative disease models confirms the essential regulatory function of GSTO1 in conserved oxidative and inflammatory cascades shared by chronic cognitive degeneration and acute perioperative brain injury. This narrative review systematically elaborates the structural characteristics, enzymatic properties, and multifaceted biological functions of GSTO1, and clarifies the potential mechanistic correlation between anesthetic/surgical stress-induced redox imbalance, neuroinflammation, and PND pathogenesis. We propose a verifiable three-axis regulatory framework centered on the Nrf2 antioxidant pathway, NF-κB inflammatory cascade, and NLRP3 inflammasome signaling. Circulating GSTO1 in serum and platelets, detectable via ELISA and enzymatic activity assays, is proposed as a novel minimally invasive peripheral biomarker for preoperative cognitive risk stratification and central redox status evaluation. Furthermore, we differentiate context-dependent GSTO1-targeted intervention strategies, replacing vague universal modulator concepts with stage-specific therapeutic regimens for acute perioperative injury and chronic neurodegeneration. This review provides innovative theoretical foundations and targeted translational prospects for mechanistic research and clinical neuroprotective strategies against PND. - Source: PubMed
Publication date: 2026/08/19
Ma HuanhuanWang XuanWang YingWang Haiying - To characterize tear proteome changes in male non-obese diabetic (NOD) mice with Sjögren's disease (SjD)-like autoimmune dacryoadenitis and determine whether identified tear proteins are associated with lacrimal gland (LG) pathogenesis. - Source: PubMed
Publication date: 2026/07/20
Li XiaoyangAlba MarioFernandez Daniel JRamirez Alison VAbdelhamid SaraWang ChenyiEdman Maria CWhitelegge JulianHamm-Alvarez Sarah F - Cutaneous T-cell lymphomas (CTCL) are a group of non-Hodgkin T-cell lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Advanced-stage CTCL are typically aggressive, exhibiting interpatient heterogeneity in treatment response and prognosis. The underlying pathogenesis remains incompletely elucidated, posing challenges for the selection of appropriate therapies. - Source: PubMed
Publication date: 2026/07/15
Zhang ShanGuo ZhengguangLiu ZhaoruiPang ZhiyuQi FengSun HaidanSun WeiLiu Jie - Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis and significant heterogeneity. Lipid metabolic reprogramming is a key hallmark of cancer, yet its systemic characterization and clinical relevance in AML remain largely unexplored. - Source: PubMed
Publication date: 2026/06/30
Zhong FangminWang ZihaoHuang JialinJin LinfengYao FangyiWang Xiaozhong - Thymomas are rare organotypic tumors frequently associated with immune-related paraneoplastic syndromes. The genetic alterations of thymomas are largely unknown and rely on general transcription factor I (GTF2I) and Harvey rat sarcoma (HRAS) mutations. Glutathione transferase omega-1-1 (GSTO1-1) is an atypical member of the glutathione transferase superfamily involved in regulating pro-survival and anti-apoptotic pathways. The association between GSTO1-1 polymorphisms and the increased risk of different types of cancer has been investigated, but no study has focused on thymomas to date. Therefore, we have investigated whether two major GSTO1-1 genetic variants, namely GSTO1∗A140D and GSTO1∗E155del polymorphisms, might represent a risk for thymoma development. - Source: PubMed
Publication date: 2026/06/16
Piaggi SimonaCarnicelli VittoriaPardini EleonoraAprile VittorioCoppedè FabioPompella AlfonsoPetrini IacopoCorti Alessandro