GSTA1, 1_222aa, Human, E.coli
- Known as:
- GSTA1, 1_222aa, Human, E.coli
- Catalog number:
- ATGP0443
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- GSTA1 1_222aa Human .coli
Related genes to: GSTA1, 1_222aa, Human, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- GSTA1 NIH gene
- Name:
- glutathione S-transferase alpha 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-06
- Date modifiied:
- 2015-09-10
Related products to: GSTA1, 1_222aa, Human, E.coli
Related articles to: GSTA1, 1_222aa, Human, E.coli
- Hypoxia-driven vascular, immune, and metabolic remodeling is a key biological process involved in cardiovascular diseases, cancer, and other complex systemic disorders. Acute mountain sickness (AMS) is an acute manifestation of hypobaric hypoxia, but its systemic molecular features remain incompletely defined. - Source: PubMed
Publication date: 2026/09/01
Ding WenjingYang YifanWei HuayingHu XinyuZhang HaopengAili AilifeilaChen XiaolanWang QiqiXue XinyingPan Lei - Genetic variants associated with stroke prognosis remain poorly characterized at the functional level. Here, we integrated summary-data-based Mendelian randomization with brain expression quantitative trait locus data, Bayesian colocalization, and cell-type-specific analyses to identify causal genes for functional outcome measured by the modified Rankin Scale at three months post-ischemic stroke. We identified four genes with robust evidence: PYGL, GSTA1, and PTGIS as protective factors, and NFATC1 as a risk factor. Cell-type-specific analyses revealed that PYGL exerts its protective effect primarily through excitatory neurons, while the detrimental effect of NFATC1 is specific to oligodendrocytes. Mediation analyses demonstrated that white matter tract integrity and cortical thickness partially mediate the associations between these genes and stroke outcomes. Functional validation in hippocampal neuronal cells confirmed that PYGL overexpression significantly attenuated apoptosis induced by oxygen-glucose deprivation/reperfusion, whereas PYGL silencing exacerbated injury. These findings delineate a causal gene regulatory network underlying stroke prognosis, highlight the importance of neuronal energy metabolism and oligodendrocyte function in recovery, and nominate PYGL as a potential therapeutic target for promoting functional recovery after ischemic stroke. - Source: PubMed
Publication date: 2026/09/15
Li KeYuan HuiZhou Dayong - Grilled food toxicants 4-hydroxynonenal (4-HNE), benzo[a]pyrene (BaP), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) pose health risks, including non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). However, their synergistic molecular mechanisms in driving NASH to NASH-HCC progression remain unclear. We employed network toxicology (CTD, GeneCards), bioinformatics analysis of the GSE164760 dataset, machine learning (LASSO, SVM-RFE, Random Forest), SHAP interpretability analysis, immune infiltration profiling (CIBERSORT), miRNA-TF-mRNA network construction, and molecular docking to identify core genes and elucidate mechanisms. Toxicity prediction confirmed significant hepatotoxicity for all three compounds. Intersection analysis identified 8 key genes (InterGenes) enriched in oxidant detoxification, fatty acid metabolism, and chemical carcinogenesis pathways. Machine learning refined this to 6 CoreGenes (). SHAP analysis revealed that high expression of ALB, TF, GSTA1 and CYP2E1, together with low expression of GPX3 and EPHX1, correlated with increased progression risk. A CoreGenes-based diagnostic nomogram achieved exceptional performance (AUC = 0.967). Immune infiltration analysis revealed significant shifts in regulatory T cells and M2 macrophages during progression. Molecular docking confirmed strong binding affinities between the toxicants and CoreGenes proteins (e.g., BaP-GSTA1: -10.7 kcal/mol). Functional enrichment implicated dysregulated fatty acid metabolism, PPAR, and TGF-beta signaling. This study identifies GSTA1, EPHX1, CYP2E1, GPX3, ALB, and TF as pivotal biomarkers and mediators through which 4-HNE, BaP, and PhIP synergistically promote NASH-HCC progression via oxidative stress, metabolic dysfunction and remodeling of the immune microenvironment. The CoreGenes signature and multi-gene model provide a powerful tool for risk assessment and early intervention. - Source: PubMed
Publication date: 2026/08/31
Qin BingbingZhang YeLi NaLi JingLuo YuehuaTang XiZhou RuishengCui TianqiTang Ying - Triphala is a traditional three-fruit formulation with potential anticancer activity, but its ferroptosis-related mechanisms in oral cancer remain unclear. We integrated network pharmacology, transcriptomic analyses, prognostic modeling, Mendelian randomization, immune and drug-response analyses, molecular docking, and in vitro validation to investigate the Triphala-ferroptosis-oral cancer axis. Fifty-eight candidate functional genes were identified, and an eight-gene signature comprising AKR1C3, CA9, EGFR, GSTA1, MAPK8, MGST1, PPARG, and RB1 showed prognostic value across multiple cohorts. Mendelian randomization supported causal associations of MAPK8, MGST1, and PPARG with oral cancer risk. Seven Triphala-derived compounds, including epigallocatechin gallate, quercetin, kaempferol, luteolin, ellagic acid, gallic acid, and quinine, displayed favorable predicted interactions with key targets. In CAL-27 cells, Triphala altered the expression of signature genes, reduced GPX4 and SLC7A11 protein levels, increased Feand malondialdehyde, depleted glutathione and glutathione peroxidase activity, and enhanced lipid peroxidation; these effects were partially modulated by ferrostatin-1. This study advances the field by linking Triphala to a ferroptosis-based prognostic framework and experimentally demonstrating its regulation of the SLC7A11-GSH-GPX4 axis in oral cancer. - Source: PubMed
Zhao YiweiLi SiminJiang LinxinKreher DeborahSchmalz GerhardFichter AndreasHu Xianda - Adenomyosis, a common gynecologic condition of the uterus, affects women with diverse symptoms including pain. Traditionally evaluated pathologically, advanced imaging modality has led to more diagnoses including asymptomatic women. This noninvasive diagnosis has raised questions about disease progression and symptom development. This study aimed to investigate the cellular and molecular patterns associated with adenomyosis and adenomyosis-related pain, focusing on inflammatory processes. We employed an integrative, retrospective bioinformatic design combining publicly available bulk RNA-sequencing data from adenomyotic and control endometrium and myometrium with single-cell RNA-sequencing data from adenomyosis patients stratified by the presence of pain. - Source: PubMed
Publication date: 2026/07/08
Kwon KanghyunKwon Ji YoungSheen KisungYu SanghyeonKim Ye-AhYoo Eun HeeLee KiwonKim Man S