TBCA , 1_108aa, Human, Recombinant, E.coli
- Known as:
- TBCA , 1_108aa, Human, Recombinant, E.coli
- Catalog number:
- ATGP0333
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- TBCA 1_108aa Human Recombinant .coli
Related genes to: TBCA , 1_108aa, Human, Recombinant, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- TBCA NIH gene
- Name:
- tubulin folding cofactor A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-31
- Date modifiied:
- 2015-08-26
Related products to: TBCA , 1_108aa, Human, Recombinant, E.coli
Related articles to: TBCA , 1_108aa, Human, Recombinant, E.coli
- Dietary patterns increasingly influence research on neurodegenerative diseases, with attention shifting from isolated nutrients to integrative nutritional models. The Amazonian Diet, a biodiversity-based dietary pattern rich in native fruits, seeds, freshwater fish, and cassava-derived foods, is naturally enriched in bioactive compounds including polyphenols, anthocyanins, carotenoids, methylxanthines, selenium, vitamins, and unsaturated fatty acids. This review aimed to investigate the potential relevance of key foods derived from the Amazonian Diet to Parkinson's disease (PD) by integrating compositional nutritional analysis, multivariate analytical approaches, and mechanistic evidence synthesis. In Stage 1, the composition of 36 Amazonian foods was analyzed using TBCA and FAO data, followed by hierarchical clustering analysis (Ward's linkage, Euclidean distance). Distinct compositional patterns were identified, highlighting foods with high bioactive diversity, relevant lipid composition, and dietary fiber. In Stage 2, an integrative literature review (PubMed/MEDLINE, SciELO) of in vitro, in vivo, observational, and clinical studies suggested that açaí berry, guaraná, cocoa/cacao, camu-camu, and Brazil nuts contain nutrients and bioactive compounds that intersect with biological pathways implicated in PD, including oxidative stress, mitochondrial dysfunction, and neuroinflammation. However, this review does not evaluate the effects of the Amazonian Diet on PD incidence, progression, symptoms, levodopa response, or biomarkers. - Source: PubMed
Publication date: 2026/07/30
Manica-Cattani Maria Fernandada Cruz Ivana Beatrice MânicaRibeiro Euler EstevesPraia Raquel de SouzaMaranghello CristinaJung Ivo EmilioAzzolin Vitória FarinaMaia Railla da SilvaMontano Marco Aurélio EchartNascimento VanusaMartin Eduardo VélezAzzolin Verônica Farina - Senescence, a key aging mechanism, is linked to disease via the senescence-associated secretory phenotype (SASP), yet its role in dementia remains unclear. We aimed to identify a minimal circulating SASP protein panel to predict incident dementia and identify causally-associated proteins. Among midlife and late-life participants from the Atherosclerosis Risk in Communities (ARIC) study, we developed three weighted SASP protein scores via multivariable Cox proportional hazards or Lasso Cox regression. Cox proportional hazards regression estimated associations between each standardized score (mean = 0; SD = 1) and incident dementia in an independent ARIC sample and validated in the Multi-Ethnic Study of Atherosclerosis (MESA). Mendelian randomization analyses evaluated causal relationships between SASP proteins and dementia risk. Comparable significant associations were observed across scores in ARIC (per 1 SD: HRs: midlife 1.20-1.33; late-life 1.39-1.50) and MESA (midlife: 1.28-1.38; late-life 1.40-1.62), with stronger associations for late-life scores. Tubulin folding cofactor A protein was the only protein causally associated with incident dementia. SASP scores, even with few proteins, are useful dementia biomarkers, and TBCA is a promising therapeutic target. - Source: PubMed
Publication date: 2026/03/26
Prizment AnnaPark SaeunRao ZexiWang ShuoLutsey Pamela LPankow JimSullivan Shannon MTang WeihongSabayan BehnamHughes Timothy MWalker Keenan ADubin RuthDeo RajatPost WendyRotter Jerome IWood Alexis CGanz PeterGuan WeihuaSedaghat Sanaz - There is growing evidence linking the consumption of ultra-processed foods (UPFs) to adverse health outcomes. Accurate classification of foods according to the extent and purpose of industrial processing is therefore essential for improving dietary assessment and public health strategies. This study aimed to evaluate and compare the performance of two large language models (LLMs), DeepSeek-R1 and ChatGPT o1, in classifying foods according to the NOVA classification system. - Source: PubMed
Publication date: 2025/12/11
Cattem Marcus Vinicius de OliveiraMachado Felipe Olasagastida Silva Maria Eduarda GuerreiroCanella Daniela SilvaKoury Josely Correa - Identifying spatially resolved proteomes has advanced markedly, yet integrating definitive protein identification with precise spatial localization in a single workflow remains challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables antibody-free mapping of proteins in tissue sections, but its capacity for unambiguous identification is limited. Here, we present a combined MALDI-MSI and liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach to map protein localization and track spatial changes in murine thymus during chemotherapy-induced involution and regeneration. Our workflow incorporates a scoring algorithm (pepBridge) that aligns MALDI-MSI molecular signals with LC-MS/MS identifications, enabling confident assignment of proteins, critical to thymic function. Using this pipeline, we reveal spatiotemporal changes in proteins involved in cell migration, cytoskeletal remodeling, and thymic regeneration. Notably, we identify distinct spatial shifts in nucleoprotein TPR and tubulin-associated chaperone A (TBCA), corresponding to chemotherapy-driven architectural remodeling. Translationally, these findings highlight pathways and targets to promote immune recovery in pediatric cancer patients undergoing cytoreductive therapy. Analytically, this framework advances spatial proteomics by enabling high-confidence protein identification in lymphoid tissues, broadening the potential of translational proteomic research. - Source: PubMed
Publication date: 2025/11/20
Aguilan Jennifer TMadrid-Aliste CarlosFischer JoshuaLagou Maria KSidoli SimoneKaragiannis George S - Reliable biomarkers that assist in the diagnosis of autism spectrum disorder (ASD) are limited. This study aimed to identify proteins that can differentiate children with ASD from controls. - Source: PubMed
Publication date: 2025/09/13
Lee TaeyeopYu JiyoungAhn Hee SungYeom JeonghunHyun YerinKim Ju YeonHong JeongyeonYoo Jung-YoonKim KyunggonKim Hyo-Won