FABP7, 1_132aa, Human, Recombinant, E.coli
- Known as:
- FABP7, 1_132aa, Human, Recombinant, E.coli
- Catalog number:
- FAB0801
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- FABP7 1_132aa Human Recombinant .coli
Related genes to: FABP7, 1_132aa, Human, Recombinant, E.coli
- Gene:
- FABP7 NIH gene
- Name:
- fatty acid binding protein 7
- Previous symbol:
- -
- Synonyms:
- B-FABP, BLBP
- Chromosome:
- 6q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-20
- Date modifiied:
- 2016-10-05
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
Related products to: FABP7, 1_132aa, Human, Recombinant, E.coli
Related articles to: FABP7, 1_132aa, Human, Recombinant, E.coli
- Fatty acid-binding proteins (FABPs) are intracellular lipid chaperones that regulate fatty acids and metabolism and signaling. Although Fabp3 and Fabp7 expression has been described in the rodent cochlea, detailed characterization in a primate model has not been performed. This study investigated the spatial and temporal expression patterns of FABP3 and FABP7 in the cochlea of the common marmoset. - Source: PubMed
Publication date: 2026/08/22
Hosoya MakotoSuda SatoshiUeno MasafumiShimanuki Marie NNishiyama TakanoriOishi NaokiOzawa Hiroyuki - Metastasis remains the primary cause of breast cancer mortality. Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. It lacks targeted therapies and carries a high risk of metastasis. MiRNAs are one of the potential diagnostics and therapeutic biomarkers, given that the regulation of mRNA is critical for tumor growth and metastatic transformation of tumor cells. Identifying the differential expression of the miRNA-mRNA axis at the primary tumor site will provide novel molecular mechanisms for metastasis initiation. In this study, we applied an integrated approach to explore the metastasis-specific miRNA-mRNA regulatory axis in TNBC using TCGA-derived miRNA-seq and RNA-seq data. Differential expression analysis between metastatic and non-metastatic TNBC patient data identified 11 dysregulated miRNAs, of which 8 showed linear expression changes with increasing disease aggressiveness. Among them, hsa-miR-1-1/2, hsa-miR-9, and hsa-miR-1180 displayed strong diagnostic potential (AUC >0.8) and significant associations with overall survival in metastatic TNBC patients. Parallel RNA-seq analysis revealed 36 differentially expressed genes (DEGs). Target prediction highlighted that only hsa-miR-9-5p targeted three of the 36 DEGs-FABP7, GPR26, and UNC5D, where FABP7 demonstrated strong association with cancer pathways. The expression of these genes was also correlated with the overall survival of the TNBC patients. Validation of this axis in various breast cancer cells (metastatic and non-metastatic) was performed, and the results indicated an inverse expression pattern of hsa-miR-9-5p and FABP7, especially in metastatic TNBC cells. These findings propose the hsa-miR-9-FABP7 axis as a promising biomarker signature for predicting metastatic potential from primary TNBC tumors. - Source: PubMed
Publication date: 2026/07/24
Rathore DeepshikhaDheer VasundharaSingh SurbhiPatel ShanayaDesai ChiragDave Heena V - Astrocytes in the mouse hippocampal dentate gyrus (DG) derive, at least in part, from BLBP+ cells, but the mechanism that controls the onset of their differentiation remains poorly understood. To address this, we first characterised the developmental dynamics of BLBP+ cells using Ki67 and the cyclin-dependent kinase inhibitor p57. Ki67+/BLBP+ proliferative progenitors peaked at P1 and declined by P3-P6, when p57+/BLBP+ early-differentiating astrocytes instead accumulated. This temporal switch prompted us to examine what maintains the proliferative pool and restricts premature differentiation. We identified Sox4, a downstream transcription factor of TGFβ signalling, as a selective marker of the undifferentiated astrocytic lineage in the developing DG. At E15-E17, Sox4 was co-expressed with BLBP and pVimentin in basal radial glia (bRG), and at P1-P6 with BLBP, Sox3 and Ki67 in proliferative glial progenitors including the Olig2+/BLBP+ astrocyte progenitors (ASPs) we recently identified. Our data further suggest that Sox4 marks ASPs but not either NeuroD+ neuronal progenitors or p57+/BLBP+ early-differentiating astrocytes. From P14 onwards, Sox4 expression persisted in a subpopulation of BLBP+ radial glia-like cells (RGLs) at the SGZ and in BLBP+ cells in the molecular layer. Together, these data suggest that Sox4 selectively marks BLBP+ glial progenitors (bRG, RGLs and ASPs) but not their differentiated progeny. Consistent with an autocrine TGFβ1-Sox4 pathway described in glioma-initiating cells, TGFβ1 was co-expressed with BLBP in bRG, RGLs and ASPs. Blockade of TGFβ signalling with SB431542 in DG explants depleted Sox4+ progenitors and, in turn, promoted the accumulation of p57+/BLBP+ astrocytes. Our data thus suggest that TGFβ signalling maintains Sox4+ progenitors and thereby restricts the early differentiation of BLBP+ astrocytes in the mouse DG. - Source: PubMed
Publication date: 2026/07/01
Ohyama KyojiOmura ShoichiroTakayama NatsumiTakahashi Tokiharu - Oocyte quality determines fertilization success during the reproductive period of fish and is affected by a key intrinsic factor: the level of lipid deposition in the yolk. In this study, lipidomics was used to characterize lipid profiles of adipose tissue, liver, serum and ovary to clarify divergent hepatic lipid allocation to fat depots versus ovary in Sichuan taimen (). The results showed that glycerophospholipids (GPs) constituted the most diverse lipid class across all four tissues, with phosphatidylcholine (PC) being the most abundant in each tissue. Relative to adipose tissue, liver, and serum, the ovary exhibited significant enrichment of PC and phosphatidylethanolamine (PE) and higher accumulation of docosahexaenoic acid (DHA)- and arachidonic acid (ARA)-containing GPs and triacylglycerols (TGs), as well as enrichment in TGs, diacylglycerols (DGs), and cardiolipin (CL), compared to adipose tissue. The expression levels of , , , , , , , and were higher in the liver, while was highly expressed specifically in the ovary. The results of this study demonstrate that long-chain polyunsaturated fatty acids (LC-PUFAs) exhibited selective enrichment in the ovary, which facilitates yolk lipid deposition and provides structural and energetic support for oocyte development and early embryonic development. From a lipidomic perspective, this study reveals the regulatory characteristics underlying ovarian yolk deposition in , providing important evidence for understanding the mechanisms of egg quality formation as well as a theoretical basis for broodstock management, artificial propagation, and the improvement of egg and larval quality. - Source: PubMed
Publication date: 2026/07/02
Wei QinyaoChen YeyuWang FubinShao WeiRu YongshenYang HuanchaoDu JunSong ZhaobinLai ZhenmingLi Hua - Fatty acid-binding protein 7 (FABP7) is a multifunctional lipid chaperone that is enriched in radial glia and astrocytes within the central nervous system (CNS) and is frequently upregulated in glioma. Beyond its established roles in glial development, lipid homeostasis, and circadian regulation, growing evidence positions FABP7 at the intersection of tumor metabolism, neuronal activity, and immune modulation in the brain. In this review, we integrate the physiological functions of FABP7 in glial cells with its tumor-intrinsic and microenvironmental roles in glioma. We summarize how gliomas co-opt FABP7-dependent metabolic, transcriptional, and post-transcriptional programs to promote stemness, lipid remodeling (e.g., altered fatty acid composition, lipid droplet formation, and lipid peroxidation resistance), inflammatory signaling, and invasive growth, including nuclear FABP7-mediated transcriptional activation linked to oncogene status. Furthermore, we discuss the role of FABP7 in shaping the tumor-neuro-immune interface, including regulating immunosuppressive gene networks, pro-tumoral macrophage polarization, resistance to T-cell-induced ferroptosis and immunotherapy, and tumor microtube-mediated integration into neuronal circuits to support glioma progression. Finally, we highlight therapeutic opportunities and challenges, including small-molecule FABP7 inhibitors, brain-directed delivery strategies, chronotherapeutic considerations, and combination approaches with immunotherapy. Collectively, this work positions FABP7-centered metabolic, circadian, and neuro-immune networks as potential vulnerabilities in glioma, linking fundamental glial biology to glioma therapeutics. - Source: PubMed
Publication date: 2026/06/23
Lee YoolKee YeenaBhoumik SukanyaFlores Carlos CZepeda-Reyes JorgeNasinec Dylan ABurpee PeytonSchell MonteOwada YujiGerstner Jason R