G_CSF, Human, Recombinant, E.coli
- Known as:
- G_CSF, Human, Recombinant, E.coli
- Catalog number:
- CSF4001
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- G_CSF Human Recombinant .coli
Related genes to: G_CSF, Human, Recombinant, E.coli
- Gene:
- CSF3 NIH gene
- Name:
- colony stimulating factor 3
- Previous symbol:
- GCSF, G-CSF, C17orf33
- Synonyms:
- MGC45931
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
- Gene:
- CSF3R NIH gene
- Name:
- colony stimulating factor 3 receptor
- Previous symbol:
- CD114
- Synonyms:
- GCSFR
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-12-10
- Date modifiied:
- 2019-04-23
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
Related products to: G_CSF, Human, Recombinant, E.coli
Related articles to: G_CSF, Human, Recombinant, E.coli
- This study investigates the therapeutic potential of the synthetic cannabinoid WIN55,212-2 (WIN55) in temporomandibular joint osteoarthritis (TMJOA), focusing on its capacity to attenuate cartilage degradation and modulate inflammatory pathways, thereby providing preclinical evidence to support future clinical translation. - Source: PubMed
Publication date: 2026/09/18
Guo YimanZhang XinchengZhao ShenBian CeZhu MengyaoSu ChengjunZhang YuqingLiu MiaoKurahara Lin-HaiZhang Ning - IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substantially between diseases, raising the possibility that the composition and regulation of T17 states are disease context dependent. - Source: PubMed
Publication date: 2026/08/14
Park NayoungLee JongeunKim DayeonRambhia DarshnaKim JaebumZhou WeiCao JunyueKrueger James GKo YounheeKim Jaehwan - Cassava-based fufu is widely consumed but nutritionally limited, particularly in micronutrients. Incorporation of orange-fleshed sweet potato (OFSP) may enhance its nutritional value. This study evaluated the nutrient composition, microbial safety, functional properties and contribution to recommended dietary allowance (RDA) of cassava-orange-fleshed sweet potato composite fufu flour for adults and children. Four blends were formulated: CONTROL (100% CF, Control), CSF1 (90% CF:10% OFSPF), CSF2 (80% CF:20% OFSPF), and CSF3 (70% CF:30% OFSPF). Nutrient composition, functional properties, microbial safety, pasting behavior, carotene content, and sensory attributes were analyzed using standard methods. Moisture (5.54-6.41%), ash (1.05-2.10%), crude fiber (0.23-1.91%), fat (1.80-9.96%), protein (2.02-7.82%), and carbohydrates (77.60-87.32%) varied significantly (p < 0.05) across blends. Pasting properties revealed: peak time (46.4 -5.63 s), pasting temperature (74.47-77.53 °C). Peak viscosity (26.0-44.6 RVU), minimum viscosity (12.67-14.83RVU), Ultimate viscosity (18.1-31.5 RVU), Attenuation value (142.5-354.5 RVU), and regeneration value (63.0-208 BVU). These results indicate that the inclusion of OFSPF modifies starch gelatinization behavior and improves paste stability. Microbial counts remained within safe limits during storage, with sample CSF2 (80% CF:20% OFSPF) and CSF1 (90% CF:10% OFSPF) having no fungal growth at 35 days. Although CSF3 exhibited the highest carotene (276.87 µg/g) and protein contents (7.82%), CSF2 provided a more balanced combination of nutrient enhancement and functional properties, and was therefore considered the most suitable formulation. This product has potential as a food-based strategy to combat micronutrient deficiencies in vulnerable populations. - Source: PubMed
Publication date: 2026/07/23
Elemuo G KUdemba C ONjuwa E GOnwuzuruike U AEmetole J M - Patients with gastric cancer (GC) and peritoneal metastasis (PM) have poor prognoses due to drug resistance and metastatic relapse. The mechanism underlying PM recurrence remains unclear. - Source: PubMed
Publication date: 2026/07/28
Chen QianZhang LuChen BiyingLi MengjieZhang MuzixianLiu YirouSun MengJiang YuchaoHong MengtingDing YinuoYang YingshuoNi JiaojiaoYing JieerZhou TianhuaZhuo Wei - Periodontitis is a complex inflammatory disease in which chronic immune activation drives destruction of periodontal soft tissues and alveolar bone. Although early-onset forms show high heritability, much genetic risk remains unresolved. To identify shared genetic signals across early- and later-onset periodontitis, we combined two European genome-wide association study datasets (3183 cases, 10 326 controls) and applied Fisher's combined probability test (FCOMB) and effect-size-based genome-wide association meta-analysis (GWAMA) across > 7 million variants to capture shared signals with either heterogeneous or more concordant effect sizes. We confirmed known associations at SIGLEC5 and DEFA1A3 and identified several additional suggestive loci. Among these, FCOMB highlighted the strongest signal at the long non-coding RNA LINC01541 (rs11876034, P = 1.7 × 10-6). We evaluated the biological relevance of LINC01541 by repressing it in gingival fibroblasts using CRISPR interference. Knockdown led to significant downregulation of inflammatory mediators, including CSF2 and CSF3, regulators of neutrophil recruitment, members of the interleukin (IL) family (IL1B, IL36B, IL36RN), and chemokines (CXCL5, CXCL8, CCL20). Six of the top ten differentially expressed genes belonged to an epithelial keratinization expression cluster. Gene-set enrichment analyses following linc01541 knockdown demonstrated repression of cytokine signaling, with IL-10 signaling most affected (padj = 5.3 × 10-14; AUC = 0.81), alongside activation of cell-cycle pathways (padj = 3.3 × 10-24; AUC = 0.73). We demonstrated the utility of aggregating heterogeneous samples to detect modest but biologically meaningful genetic effects. The convergence of the genetic association at LINC01541 with functional evidence suggests that this lncRNA modulates an upstream mucosal inflammatory axis relevant to periodontal pathogenesis. - Source: PubMed
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