Recombinant Human G_CSF
- Known as:
- Recombinant Human G_CSF
- Catalog number:
- SJA02-05
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Cytokin
- Gene target:
- Recombinant Human G_CSF
Related genes to: Recombinant Human G_CSF
- Gene:
- CSF3 NIH gene
- Name:
- colony stimulating factor 3
- Previous symbol:
- GCSF, G-CSF, C17orf33
- Synonyms:
- MGC45931
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
- Gene:
- CSF3R NIH gene
- Name:
- colony stimulating factor 3 receptor
- Previous symbol:
- CD114
- Synonyms:
- GCSFR
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-12-10
- Date modifiied:
- 2019-04-23
Related products to: Recombinant Human G_CSF
Related articles to: Recombinant Human G_CSF
- IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substantially between diseases, raising the possibility that the composition and regulation of T17 states are disease context dependent. - Source: PubMed
Publication date: 2026/08/14
Park NayoungLee JongeunKim DayeonRambhia DarshnaKim JaebumZhou WeiCao JunyueKrueger James GKo YounheeKim Jaehwan - Cassava-based fufu is widely consumed but nutritionally limited, particularly in micronutrients. Incorporation of orange-fleshed sweet potato (OFSP) may enhance its nutritional value. This study evaluated the nutrient composition, microbial safety, functional properties and contribution to recommended dietary allowance (RDA) of cassava-orange-fleshed sweet potato composite fufu flour for adults and children. Four blends were formulated: CONTROL (100% CF, Control), CSF1 (90% CF:10% OFSPF), CSF2 (80% CF:20% OFSPF), and CSF3 (70% CF:30% OFSPF). Nutrient composition, functional properties, microbial safety, pasting behavior, carotene content, and sensory attributes were analyzed using standard methods. Moisture (5.54-6.41%), ash (1.05-2.10%), crude fiber (0.23-1.91%), fat (1.80-9.96%), protein (2.02-7.82%), and carbohydrates (77.60-87.32%) varied significantly (p < 0.05) across blends. Pasting properties revealed: peak time (46.4 -5.63 s), pasting temperature (74.47-77.53 °C). Peak viscosity (26.0-44.6 RVU), minimum viscosity (12.67-14.83RVU), Ultimate viscosity (18.1-31.5 RVU), Attenuation value (142.5-354.5 RVU), and regeneration value (63.0-208 BVU). These results indicate that the inclusion of OFSPF modifies starch gelatinization behavior and improves paste stability. Microbial counts remained within safe limits during storage, with sample CSF2 (80% CF:20% OFSPF) and CSF1 (90% CF:10% OFSPF) having no fungal growth at 35 days. Although CSF3 exhibited the highest carotene (276.87 µg/g) and protein contents (7.82%), CSF2 provided a more balanced combination of nutrient enhancement and functional properties, and was therefore considered the most suitable formulation. This product has potential as a food-based strategy to combat micronutrient deficiencies in vulnerable populations. - Source: PubMed
Publication date: 2026/07/23
Elemuo G KUdemba C ONjuwa E GOnwuzuruike U AEmetole J M - Patients with gastric cancer (GC) and peritoneal metastasis (PM) have poor prognoses due to drug resistance and metastatic relapse. The mechanism underlying PM recurrence remains unclear. - Source: PubMed
Publication date: 2026/07/28
Chen QianZhang LuChen BiyingLi MengjieZhang MuzixianLiu YirouSun MengJiang YuchaoHong MengtingDing YinuoYang YingshuoNi JiaojiaoYing JieerZhou TianhuaZhuo Wei - Periodontitis is a complex inflammatory disease in which chronic immune activation drives destruction of periodontal soft tissues and alveolar bone. Although early-onset forms show high heritability, much genetic risk remains unresolved. To identify shared genetic signals across early- and later-onset periodontitis, we combined two European genome-wide association study datasets (3183 cases, 10 326 controls) and applied Fisher's combined probability test (FCOMB) and effect-size-based genome-wide association meta-analysis (GWAMA) across > 7 million variants to capture shared signals with either heterogeneous or more concordant effect sizes. We confirmed known associations at SIGLEC5 and DEFA1A3 and identified several additional suggestive loci. Among these, FCOMB highlighted the strongest signal at the long non-coding RNA LINC01541 (rs11876034, P = 1.7 × 10-6). We evaluated the biological relevance of LINC01541 by repressing it in gingival fibroblasts using CRISPR interference. Knockdown led to significant downregulation of inflammatory mediators, including CSF2 and CSF3, regulators of neutrophil recruitment, members of the interleukin (IL) family (IL1B, IL36B, IL36RN), and chemokines (CXCL5, CXCL8, CCL20). Six of the top ten differentially expressed genes belonged to an epithelial keratinization expression cluster. Gene-set enrichment analyses following linc01541 knockdown demonstrated repression of cytokine signaling, with IL-10 signaling most affected (padj = 5.3 × 10-14; AUC = 0.81), alongside activation of cell-cycle pathways (padj = 3.3 × 10-24; AUC = 0.73). We demonstrated the utility of aggregating heterogeneous samples to detect modest but biologically meaningful genetic effects. The convergence of the genetic association at LINC01541 with functional evidence suggests that this lncRNA modulates an upstream mucosal inflammatory axis relevant to periodontal pathogenesis. - Source: PubMed
Richter Gesa MAkinloye Oluwabukunmi MKühnlenz TimWeiner January RdHoltfreter Birtede Coo AliciaDiz-De Almeida SilviaLoos Bruno GJepsen SørenDommisch HenrikBruckmann CorinnaKapferer-Seebacher InesHomuth GeorgKocher ThomasVölzke HenryBerger KlausLaudes MatthiasLieb Wolfgangvan der Velde Nathalievan Schoor Natasja Mde Groot LisetteBlanco JuanCarracedo AngelCruz RaquelDempfle AstridTeumer AlexanderFreitag-Wolf SandraSchaefer Arne S - Colon adenocarcinoma (COAD) remains a leading cause of cancer-related mortality worldwide, partly due to the lack of robust biomarkers for early diagnosis and accurate prognosis. Glycoproteins play critical roles in tumorigenesis and may serve as promising sources of biomarkers. This study aimed to identify glycoprotein-related candidate diagnostic and prognostic biomarkers for COAD through integrated bioinformatics approaches and experimental validation. Gene expression profiles and clinical information of COAD patients were obtained from The Cancer Genome Atlas database (TCGA). The expression data for genes associated with glycoprotein were retrieved from the UniProt database. Furthermore, we assessed the mRNA expression levels of the glycoprotein FJX1 in COAD and rectal adenocarcinoma tissues through in situ hybridization (ISH) staining using tissue microarrays. A total of 228 glycoprotein-related differentially expressed genes (DEGs) were identified, enriched in the extracellular matrix organization and signaling pathways such as PI3K-Akt and cAMP. Protein-protein interaction (PPI) network analysis revealed 10 hub genes (LIFR, CNTFR, LIF, CSF2, IL1A, CSF3, F2, FGA, FGFR2, INHBA). Survival screening and multivariate Cox regression identified FJX1 as an independent prognostic factor for overall survival after adjusting for age and stage. FJX1 mRNA was significantly overexpressed in COAD tissues compared to normal (p < 0.001), and high FJX1 expression correlated with advanced T stage, M stage, and pathological stage. ISH confirmed elevated FJX1 mRNA in tumors. Immune infiltration analysis further revealed that high FJX1 expression was associated with increased infiltration of M0 macrophages and neutrophils, and decreased resting memory CD4 T cells, suggesting a potential role in shaping the immunosuppressive tumor microenvironment. GSEA revealed significant enrichment of MAPK signaling in high-FJX1 tumors. In conclusion, this study identified 10 glycoprotein-related hub genes as candidate diagnostic biomarkers warranting further validation and established FJX1 as an independent prognostic biomarker for COAD. FJX1 overexpression is associated with tumor progression and may be linked to MAPK signaling as well as immune modulation. These findings provide a foundation for glycoprotein-based biomarker development in COAD. - Source: PubMed
Publication date: 2026/05/18
Liu HaiyunWan LinjingFang Quangang