DKK-1 Fc, Human
- Known as:
- DKK-1 Fc, Human
- Catalog number:
- P723-50
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- 101 Bio.
- Gene target:
- DKK-1 Human
Related genes to: DKK-1 Fc, Human
- Gene:
- DKK1 NIH gene
- Name:
- dickkopf WNT signaling pathway inhibitor 1
- Previous symbol:
- -
- Synonyms:
- SK, DKK-1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-06-28
Related products to: DKK-1 Fc, Human
Related articles to: DKK-1 Fc, Human
- Osteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical role in osteoporotic bone loss. Neutralization of DKK-1 represents a promising therapeutic strategy to promote bone formation while simultaneously inhibiting bone resorption. - Source: PubMed
Publication date: 2026/08/27
Hou ShengGao TianyuWu YimeiWang HaoZhang DapengGuo QingchengXu JinGuo HuaizuQian Weizhu - Oral squamous cell carcinoma (OSCC) is a malignant tumor arising from the oral mucosa and is highly prevalent in Southeast Asia and the Pacific region. Recurrence and metastasis significantly contribute to poor clinical outcomes, highlighting the importance of understanding the underlying molecular mechanisms. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs, have emerged as key regulators of tumor development and progression. However, their roles in OSCC remain largely unexplored. In this study, we identified for the first time that circRHBDD1(4,5) (hsa_circ_0058493, a 656-nt circRNA generated by back-splicing of exons 4 and 5 of the RHBDD1 gene) is markedly upregulated in OSCC and promotes tumor cell proliferation, invasion, and metastasis. Mechanistically, circRHBDD1(4,5) functions as a molecular scaffold that brings IGF2BP2 and DKK1 mRNA into close proximity, thereby facilitating the mA-dependent recognition of DKK1 mRNA by IGF2BP2, which is mediated by WTAP. This interaction enhances DKK1 mRNA stability, leading to increased DKK1 expression and subsequent activation of the PI3K-AKT signaling pathway, thereby driving the malignant progression in OSCC. Collectively, our findings highlight the critical role of the circRHBDD1(4,5)/IGF2BP2/DKK1 axis in OSCC pathogenesis and provide a potential foundation for developing novel targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/09/11
Ren DaixiZhang JiarongHuang MaoWu JieYang MeiLiu YixuanXiang PingjuanQu HongkeWang DanGe JunshangYan QijiaShi LeiXiang BoXiong WeiLi GuiyuanFan ChunmeiZeng Zhaoyang - Osteoarthritis (OA) is a chronic, age-related disease that severely impairs the quality of life. The pathogenesis of OA remains unknown, and current pharmacological treatments are still limited. Thus, it is urgent to identify disease targets and develop more effective therapeutic agents for OA. - Source: PubMed
Publication date: 2026/09/09
Yuan YueSun QiangHui TengLiu YiranLi YanWang GanWang ChangliFeng GuodongWang JingWang ZengluKang JiefangYan YapingWang LeiLiu YanXue XiaochangZhang Dawei - Thyroid cancer, the most frequent endocrine tumor, has a good prognosis. However, the survival rate of patients with recurrent or metastatic forms that become resistant to conventional treatments, drops to less than 20% at 10 years, with a mean life expectancy of 3-5 years. The molecular mechanisms that drive the advancement of these forms are still largely unknown, and, therefore, the identification of disease progression biomarkers is of great clinical relevance. Dickkopf-1 (DKK1) is a regulator of the Wnt signaling cascade that controls several biological processes including cell proliferation, differentiation and migration. DKK1 has been associated with progression and poor prognosis in different types of tumors; however, its role in thyroid cancer is still not well defined, and a better characterization is needed. The present study investigated the role of DKK1 in the growth of papillary and follicular thyroid cancers, in in vitro and in vivo models. In vitro, DKK1 silencing, through siRNA, and deletion, via CRISPR/Cas9 editing, were performed in different papillary and follicular thyroid cancer cell lines. Both silencing and deletion reduced cell growth and migration, with the involvement of β-catenin-dependent Wnt and PI3K/mTOR pathways. In vivo xenograft tumor models, DKK1 deletion reduced tumor growth. In conclusion, our findings support the key role of DKK1 in the growth of differentiated thyroid cancers both in vitro and in vivo. - Source: PubMed
Publication date: 2026/09/07
Fiorentino GloriaLatiano BeatriceRinella LetiziaGrange CristinaCedrino MassimoBosco OrnellaPighi ChiaraPerin LauraArvat EmanuelaCatalano Maria Graziella - Lipid metabolism-related genes (LMRGs) are crucial in head and neck squamous cell carcinoma (HNSCC) progression. This study aimed to construct and validate a prognostic model for HNSCC based on LMRGs. - Source: PubMed
Publication date: 2026/09/04
Xie Ting-ZhiSun Xin-YiWang JingWang ZhiDu NingGe Xi-Yuan