DKK-1 Fc, Human
- Known as:
- DKK-1 Fc, Human
- Catalog number:
- P723-50
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- 101 Bio.
- Gene target:
- DKK-1 Human
Related genes to: DKK-1 Fc, Human
- Gene:
- DKK1 NIH gene
- Name:
- dickkopf WNT signaling pathway inhibitor 1
- Previous symbol:
- -
- Synonyms:
- SK, DKK-1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-06-28
Related products to: DKK-1 Fc, Human
Related articles to: DKK-1 Fc, Human
- Thyroid cancer, the most frequent endocrine tumor, has a good prognosis. However, the survival rate of patients with recurrent or metastatic forms that become resistant to conventional treatments, drops to less than 20% at 10 years, with a mean life expectancy of 3-5 years. The molecular mechanisms that drive the advancement of these forms are still largely unknown, and, therefore, the identification of disease progression biomarkers is of great clinical relevance. Dickkopf-1 (DKK1) is a regulator of the Wnt signaling cascade that controls several biological processes including cell proliferation, differentiation and migration. DKK1 has been associated with progression and poor prognosis in different types of tumors; however, its role in thyroid cancer is still not well defined, and a better characterization is needed. The present study investigated the role of DKK1 in the growth of papillary and follicular thyroid cancers, in in vitro and in vivo models. In vitro, DKK1 silencing, through siRNA, and deletion, via CRISPR/Cas9 editing, were performed in different papillary and follicular thyroid cancer cell lines. Both silencing and deletion reduced cell growth and migration, with the involvement of β-catenin-dependent Wnt and PI3K/mTOR pathways. In vivo xenograft tumor models, DKK1 deletion reduced tumor growth. In conclusion, our findings support the key role of DKK1 in the growth of differentiated thyroid cancers both in vitro and in vivo. - Source: PubMed
Publication date: 2026/09/07
Fiorentino GloriaLatiano BeatriceRinella LetiziaGrange CristinaCedrino MassimoBosco OrnellaPighi ChiaraPerin LauraArvat EmanuelaCatalano Maria Graziella - Lipid metabolism-related genes (LMRGs) are crucial in head and neck squamous cell carcinoma (HNSCC) progression. This study aimed to construct and validate a prognostic model for HNSCC based on LMRGs. - Source: PubMed
Publication date: 2026/09/04
Xie Ting-ZhiSun Xin-YiWang JingWang ZhiDu NingGe Xi-Yuan - Ferroptosis therapy holds great potential in metastatic cancer treatment. Whereas, Dickkopf-related protein-1 (DKK1) that highly expressed in various tumors might contribute to low ferroptosis sensitivity of tumor cells, which imposed restrictions on ferroptosis therapy. Our research revealed that DKK1 inhibition could sensitive tumor cells to ferroptosis by obstructing the cystine-GSH-GPX4 axis and the CoQ-FSP1 axis. Moreover, DKK1 inhibition facilitated dormancy of tumor cells, thereby inhibiting their metastatic proliferation. Encouraged by that, a strategy combining DKK1 inhibition with ferroptosis induction was innovatively proposed for metastatic cancer treatment. And a sulfated hyaluronic acid (SHA)-functionalized liposome co-encapsulating DKK1 inhibitor (Gallocyanine) and ferroptosis inducer (RSL3) was developed for this purpose. The constructed SLip/G+R simultaneously targeted primary tumors, circulating tumor cells and tumor metastases by not only binding to P-selectin/CD44 on tumor cells, but also hitchhiking on activated platelets with tumor cells tendency. Particularly, SLip/G+R increased P-selectin/CD44 on tumor cells through DKK1 inhibition, providing more targets for itself and enhancing the targeting effect in a "self-promoting" manner. Due to the self-promoting ferroptosis amplification, SLip/G+R exerted excellent anti-tumor and anti-metastasis efficacy. Overall, this study provided a new idea for efficiently eliminating metastatic tumor cells. It is conducive to promoting the development of ferroptosis therapy, and is of great significance for metastatic cancer treatment. - Source: PubMed
Publication date: 2026/09/02
Guo RongLiu YingkeYin ZhaoruChen ShuangYe YunxiaJi XuxuZhang ZhengkunWang DingxueLi ManLiu Ji - Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, imposing a significant economic and physiological burden on individuals and society worldwide. Although dysregulation of the WNT/β-catenin pathway is considered an important factor contributing to the dysfunction of nucleus pulposus (NP) cells and degradation of the extracellular matrix, the mechanisms by which specific subgroups of NP cells are activated and the maintenance of excessive activation of specific pathways remain unclear. - Source: PubMed
Publication date: 2026/08/22
Li QiuweiLiang GuoyanBo KaidaKang LiangJin PeilinZhao ChenhaoZhang RenjieLyu FengjuanShen Cailiang - Secreted modulators of the Wingless (WNT) pathways are associated with cardiometabolic dysregulation. Among these, Dickkopf-1 (DKK1) and secreted frizzled-related protein-3 (sFRP3) are abundantly expressed in placental tissue and secreted into the maternal circulation. We hypothesized their plasma levels would be dysregulated in women with gestational diabetes mellitus (GDM) and correlate with indices of metabolic health. - Source: PubMed
Publication date: 2026/08/14
Ueland ThorMichelsen Annika ElisabetQvigstad ElisabethRoland Marie Cecilie PaascheWesterberg Ane CecilieMichelsen Trond MelbyeAukrust PålBollerslev JensLekva Tove