PRSS7, 785-10199aa, Human, E.coli
- Known as:
- PRSS7, 785-10199aa, Human, E.coli
- Catalog number:
- ATGP2960
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- PRSS7 785-10199aa Human .coli
Related genes to: PRSS7, 785-10199aa, Human, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- TMPRSS15 NIH gene
- Name:
- transmembrane serine protease 15
- Previous symbol:
- PRSS7
- Synonyms:
- ENTK, MGC133046
- Chromosome:
- 21q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-08-14
- Date modifiied:
- 2018-01-19
Related products to: PRSS7, 785-10199aa, Human, E.coli
Related articles to: PRSS7, 785-10199aa, Human, E.coli
- - Source: PubMed
Chen P YGeng L LGong S TXiong L YLin W HLi H WRen L - Inborn Errors of Immunity (IEI) are genetic disorders impairing the immune system, increasing susceptibility to infections, autoimmunity, inflammation, and malignancies. Mutations in over 500 genes have been shown to cause IEI. This study investigated IEI-related differential gene expression by examining the somatic transcriptomes of cancers. RNA-sequencing data from cancers were obtained from TCGA and TARGET databases, alongside healthy tissue data from GTEx, and the differentially expressed gene set was filtered for 592 IEI-related genes. To examine the differential expression of genes across cancers, odds ratios were computed for enrichment of IEI-related genes. Pathway analysis on the differentially expressed IEI-related genes identified immune pathways that are significantly represented. IEI-genes that were significantly dysregulated include TMPRSS15, SEMA3E, ANGPT1, CFH, F5, CFB, CFD, CFH, and CR2. Interestingly, complement-related pathways were the most altered in our analysis. Furthermore, IEI-related genes are more likely to be differentially expressed compared to non-IEI genes in certain cancers. This study presents bioinformatic analyses of pan-cancer genomic datasets, identifying distinct IEI-associated gene expression changes. The findings provide insights into the role of immunological pathways, specifically the complement system, in cancer. Further investigation into the identified gene alterations could advance the care of a vulnerable group of cancer patients. - Source: PubMed
Publication date: 2026/01/29
Lokanc SamuelSipila PatrickCuvelier Geoffrey D EMurguía-Favela LuisWright Nicola AmGrunebaum EyalBose PinakiNarendran Aru - Despite notable progress in psychiatric genomics, there are no validated blood-based biomarkers for psychosis. Previous studies have failed to establish a link between schizophrenia polygenic scores (PGS) and blood protein levels. We aimed to identify associations between schizophrenia PGS and blood-based proteins, and to determine whether levels of 2077 proteins differ in individuals with psychosis. We analysed proteomic and genomic data from 47,969 participants in the UK Biobank. Association analyses in the 47,678 participants without psychosis (mean age 57.1 years, standard deviation 8.1 years; 54% female) identified nominal associations (p < 0.05) of schizophrenia PGS with 102 proteins. Four of these (TMPRSS15, ADGRB3, CEACAM21, and KLK1) met the false discovery rate (FDR) threshold of < 0.05. We investigated the association of these four proteins with psychosis in a matched case-control sample (283 cases, 849 controls, mean age 56.9 years, standard deviation 8.4 years; 48% female). In individuals with psychosis, we observed significantly lower levels of KLK1, even after adjusting for potential confounders (effect size -0.25, SE 0.09, FDR 0.049). This direction of effect was opposite to that observed in the primary analysis of individuals without psychosis (effect size 324.67, SE 48.32, FDR 3.85 × 10). The effect of antipsychotic medication did not explain this difference. This protein should be taken forward for further study and validation to investigate its potential as a psychosis biomarker. - Source: PubMed
Publication date: 2026/01/14
Kendall Kimberley MLegge Sophie EFenner EilidhHolmans PeterWalters James Tr - Enterokinase deficiency (EKD,OMIM #226200) is a rare autosomal recessive genetic disorder caused by mutations in transmembrane protease serine 15 (TMPRSS15). Herein, we report a case of EKD in a patient with novel compound heterozygous TMPRSS15 mutations. - Source: PubMed
Publication date: 2025/01/29
Li YunxiLi RuijuanPan YanyanZhou WeiranWang XingcuiDong LinlinLiu XuemeiZhang Hongxia - COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH). - Source: PubMed
Publication date: 2025/01/31
Canny Susan PStanaway Ian BHolton Sarah EMitchem MallorieO'Rourke Allison RPribitzer StephanBaxter Sarah KWurfel Mark MMalhotra UmaBuckner Jane HBhatraju Pavan KMorrell Eric DSpeake CateMikacenic CarmenHamerman Jessica A