WNT3a, 19-352 aa, Human, E.coli
- Known as:
- WNT3a, 19-352 aa, Human, E.coli
- Catalog number:
- ATGP2939
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- WNT3a 19-352 Human .coli
Related genes to: WNT3a, 19-352 aa, Human, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- WNT3A NIH gene
- Name:
- Wnt family member 3A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q42.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-29
- Date modifiied:
- 2016-10-05
Related products to: WNT3a, 19-352 aa, Human, E.coli
Related articles to: WNT3a, 19-352 aa, Human, E.coli
- Ifosfamide (IFO) is an effective chemotherapeutic agent, but its clinical use is limited by dose-dependent nephrotoxicity. This study investigated the protective effects of 18β-glycyrrhetinic acid (18β-GA) against IFO-induced acute renal injury and explored the underlying molecular mechanisms. Twenty-eight male Wistar albino rats were divided into four groups: Control, 18β-GA, IFO, and IFO+18β-GA. 18β-GA was administered orally at 100 mg/kg/day for two consecutive days, while nephrotoxicity was induced by a single intraperitoneal injection of IFO at 500 mg/kg. Renal function markers, oxidative stress parameters, inflammatory and apoptotic gene expression, Wnt3a/IL-17 A/ACT1/TRAF6 and Notch/HES1 signaling pathways, histopathological alterations, ZO-1 integrity, and CHOP expression were evaluated. IFO markedly impaired renal function, increased serum urea and creatinine levels, enhanced lipid peroxidation, depleted antioxidant defenses, and induced severe histopathological damage. IFO also upregulated NF-κB, TNF-α, Bax, Caspase-3, Wnt3a, IL-17 A, ACT1, TRAF6, Notch, and HES1 expression, while reducing Bcl-2 expression. In addition, IFO increased CHOP immunoreactivity and disrupted ZO-1 expression in tubular epithelial cells. Co-treatment with 18β-GA significantly improved renal function, restored antioxidant capacity, and was associated with the suppression of inflammatory and apoptotic signaling, downregulation of Wnt3a/IL-17 A/ACT1/TRAF6 and Notch/HES1 activation, reduced CHOP expression, preserved ZO-1 immunoreactivity, and ameliorated renal histological injury. These findings suggest that 18β-GA exerts potential multi-target renoprotective effects against IFO-induced nephrotoxicity by modulating oxidative stress, inflammation, ER stress, apoptosis, developmental signaling, and epithelial junctional integrity. - Source: PubMed
Publication date: 2026/09/21
Kandemir Fatih MehmetŞimşek HasanÇelik Samancı TuğbaKandemir Özge - Ageing is associated with colon epithelial barrier disruption and up-regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut-BM axis. - Source: PubMed
Publication date: 2026/09/16
Chittimalli KishoreRozario Henryata EMartinez VictorMcAdams Zachary LAdkins Stephen AEricsson Aaron CJarajapu Yagna P R - Aberrant activation of the Wnt3A/β-catenin pathway is critically involved in the bone erosion of rheumatoid arthritis (RA). The natural flavonoid quercetin (QUE) ameliorates RA symptoms, but its mechanistic link to this pathway is poorly understood. This study investigated whether QUE attenuates bone destruction in collagen-induced arthritis (CIA) rats by inhibiting Wnt3A/β-catenin signaling. CIA rats were treated with QUE or methotrexate (MTX) for 28 days, and bone destruction, inflammatory cytokines, and the expression of Wnt3A/β-catenin were systematically assessed. - Source: PubMed
Publication date: 2026/09/15
Shen TongLiang RuiLiang MeieGuo QianyuPang Quanhai - Intestinal organoids are widely used in mammalian studies to mimic and study intestinal function and host-pathogen interactions without using of whole animal studies. For chicken, this was not yet feasible. Recently, we have shown that embryonal intestinal organoids can grow for 10-15 passages (approximately 6 weeks) when using chicken-derived Rspo1 and Wnt3. In this paper, we show that replacing Wnt3 with chicken Wnt3a and adding chicken Nrg1 and human FGF1 results in efficient and long lasting growth, over 40 weeks, of embryonal chicken intestinal organoids. Moreover, the typical branching phenotype, which is normally observed for mammalian species such as mouse and pig intestinal organoids, is now also observed in the chicken organoids when Rspo1, Wnt3a, Nrg1 and hFGF1 are used. This branching is enhanced by inhibiting FoxO1 with AS1842856, resulting in an increase of growth. Moreover, we show the presence of Lgr5 positive stem cells, goblets, endocrine cells, Paneth cells and enterocytes. In agreement with the observed presence of goblet cells, we observed mucus secretion in the 2D cultures. This new and improved culture condition for chicken intestinal organoids allows for in vitro research that can partially replace animal testing with respect to, for instance, replacement of antibiotics, feed additives and drug development. - Source: PubMed
Publication date: 2026/06/24
Klooster Jean Paul Tenvan Summeren Kittyde Louwere JasperVelkers Francisca CPieters Raymond H H - This study evaluated the combined effects of microwave-assisted Opuntia humifusa extract (MA-OHE) and Red-LED irradiation on intracellular redox status and Wnt/β-catenin-associated signaling in human hair follicle dermal papilla cells (HFDPCs). Cell viability, DCF fluorescence, DNA damage, and Wnt3a/β-catenin expression were assessed. All treatments maintained > 90% cell viability and did not significantly increase DNA damage. MA-OHE and Red-LED irradiation reduced DCF fluorescence by approximately 20%-25%, with the combined treatment showing the greatest reduction. Western blotting showed increased Wnt3a and total β-catenin expression, with the combined treatment producing the greatest numerical responses. These findings indicate that MA-OHE pretreatment followed by Red-LED irradiation may provide greater modulation of intracellular redox status and Wnt/β-catenin-associated protein expression than either treatment alone. However, true synergy and direct hair growth promotion were not established. - Source: PubMed
Ngoc Le Thi NhuMoon Ju-YoungLee Young-Chul