Centrifuge
tube
5ml (linked lid)
- Known as:
- Centrifuge
tube
5ml (linked lid)
- Catalog number:
- ZD1010
- Product Quantity:
- 4200pc/carton
- Category:
- -
- Supplier:
- Zenplastic
- Gene target:
- Centrifuge
tube
5ml (linked lid)
Related genes to: Centrifuge
tube
5ml (linked lid)
- Gene:
- RNF146 NIH gene
- Name:
- ring finger protein 146
- Previous symbol:
- -
- Synonyms:
- DKFZp434O1427, dactylidin, dJ351K20.1
- Chromosome:
- 6q22.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2016-10-05
- Gene:
- TSC2 NIH gene
- Name:
- TSC complex subunit 2
- Previous symbol:
- TSC4
- Synonyms:
- tuberin, LAM, PPP1R160
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: Centrifuge
tube
5ml (linked lid)
Related articles to: Centrifuge
tube
5ml (linked lid)
- This study analyzed the clinical and genetic characteristics of 73 pediatric patients with tuberous sclerosis complex (TSC). Through an examination of genotype-phenotype correlations, the research aimed to identify patterns in mutation characteristics to facilitate the optimization of diagnostic, therapeutic, and prognostic strategies. - Source: PubMed
Publication date: 2026/04/13
Wu XiaoHe Ming-YingXu Hai-FengHe YanMin Xiao-HuiZhao Qi-KaiLiang Shu-QiGinowree Nooraynee Bibi NeedahHu Shu-HanYin JiaFan Zi-HanDin M Jalal UdZhu MinZhang Gang - Pediatric abdominal aortic aneurysms are exceedingly rare, particularly in infants, and pose unique diagnostic and surgical challenges. We present a case of an infant diagnosed antenatally with intracardiac rhabdomyomas who later presented with infantile spasms. Neuroimaging and genetic testing confirmed tuberous sclerosis complex with a pathogenic de novo TSC2 mutation. Tuberous sclerosis complex is associated with dysregulation of the mammalian target of rapamycin (mTOR) signaling pathway, leading to abnormal vascular smooth muscle proliferation, structural vessel wall weakness, and predisposition to aneurysm formation. The increased cellular proliferation and altered vascular biology may also contribute to a prothrombotic milieu, particularly in the postoperative setting following vascular reconstruction. Systemic evaluation of the patient revealed a large fusiform infrarenal abdominal aortic aneurysm, following which the patient underwent elective open aneurysm repair using an 8-mm expanded polytetrafluoroethylene graft. The patient developed early postoperative graft thrombosis, necessitating emergency graft revision. Following re-exploration, satisfactory distal perfusion was achieved, and the postoperative recovery was uneventful. This case highlights the importance of routine vascular screening in patients with tuberous sclerosis complex, underscores the underlying pathophysiology of vascular involvement, and outlines the surgical challenges associated with managing abdominal aortic aneurysms in infancy. - Source: PubMed
Publication date: 2026/03/24
Pal AishwaryaSirivela Simha SwarajMallick ShwetaViswanathan Sidharth - Research on tuberous sclerosis complex-associated neuropsychiatric disorders (TAND) in China remains limited. This study aimed to identify determinants of TAND severity to guide clinical management. - Source: PubMed
Publication date: 2026/04/25
Qi ChenyangLi YingChen YananCui XiaoxiaoWang QiZhang XiaoliDu XiuboBai YongjieLi YanweiWen GonglingZheng WenquanYuan XiangdongLiu ShilingWang JianboFu YifanPeng XiaohanGao LiHan Xiong - Type 1 conventional dendritic cells (cDC1s) play an integral role in mediating immune responses and maintaining homeostasis, yet the molecular mechanisms underlying their functions remain poorly understood. In this study, we identified dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) as a key kinase that responded to TLR and growth factor stimulation and acted as an essential regulator of cDC1 function. Genetic ablation of Dyrk1a specifically in cDC1s impaired antitumor immunity and accelerated tumor progression in murine models. Mechanistically, DYRK1A mediated the phosphorylation of the mTORC1 inhibitor TSC2 at serine 540, triggering the degradation of TSC2 and promoting the mTORC1 signaling in cDC1s. Notably, Tsc2 deletion in Dyrk1a-deficient cDC1s remarkably restored their antitumor immune functions. Furthermore, DYRK1A-mediated mTORC1 signaling in cDC1s positively correlated with effector T-cell responses across multiple human cancers. Our findings highlight a critical role for the DYRK1A-TSC2-mTORC1 signaling pathway in regulating cDC1 functions in antitumor immunity, offering potential strategies to improve cancer immunotherapy. - Source: PubMed
Publication date: 2026/04/23
Wang HongjiaoJiang HeHe SonglinRen SongwenLi HaiwenLiu WangnanZhou ChunyunZhu PanChen KerenCao WeijiaQin YanDu DanXiao NengmingHuang HonglingKo Chun-JungZheng YimingWang BoZou QiangShi Jian-HongLi XunJie Zuliang - A 57-year-old female patient with tuberous sclerosis and end-stage renal failure who had a history of diabetes mellitus and repeated renal hemorrhage after induction of dialysis underwent surgical nephrectomy. The renal tissue that caused the hemorrhage consisted of adipocytes, blood vessels, and smooth muscle cells, so angiomyolipoma was diagnosed. The cause of the hemorrhage was thought to be an abnormality in the vascular structure, i.e., disruption of the elastic plates that make up the vessel wall, and the presence of a hematoma in the same area. Diabetic nephropathy, which was observed in the atrophied native kidney, was presumed to be the cause of end-stage renal failure. Genetic analysis confirmed the presence of TSC2 mutation, which is linked to tuberous sclerosis, and HNF1B mutation, which is linked to diabetes. To our knowledge, this is the first report of a patient with HNF1B mutation who may have developed end-stage renal failure because of diabetic nephropathy and who also had histologic evidence of renal hemorrhage. - Source: PubMed
Publication date: 2026/04/18
Sugimoto HisashiSawa NaokiOba YukiMizuno HirokiSekine AkinariYamanouchi MasayukiTanaka KihoHasegawa EikoSuwabe TatsuyaWada TakehikoYokoyama TakayoshiMiki KatsuyukiNakamura YukiIshii YasuoKono KeiOhashi KenichiTakazawa YutakaFujimaru TakuyaMori TakayasuSohara EiseiUbara Yoshifumi